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    CROSSLINKED MULTILAYERED MATERIAL COMPOSITIONS, METHODS FOR THEIR PREPARATION AND APPLICATIONS THEREOF
    1.
    发明申请
    CROSSLINKED MULTILAYERED MATERIAL COMPOSITIONS, METHODS FOR THEIR PREPARATION AND APPLICATIONS THEREOF 有权

    公开(公告)号：US20220118416A1

    公开(公告)日：2022-04-21

    申请号：US17503063

    申请日：2021-10-15

    申请人： Pathak Holdings LLC

    发明人： Chandrashekhar P. Pathak ,  Milind M. Thigle

    IPC分类号： B01J13/00 ,  C08F2/50 ,  A61K47/69

    摘要： Novel composite materials and their methods of preparation comprising a crosslinked biodegradable polymer and non-crosslinked biodegradable polymers are disclosed. The composite materials can be formed into injectable compositions comprising composite microparticles or microspheres. The non-crosslinked biodegradable polymer in the composite material is synthesized or precipitated in situ inside the particle. The non-crosslinked biodegradable polymer in the composite may be liquid, low melting solid or polymer with thermosensitive or pH sensitive gelation properties. Also disclosed are injectable compositions comprising microparticles or microspheres for controlled drug delivery wherein such particles are delivered using organic solvents. Also disclosed are methods and compositions for making two or more layered particles for medical and industrial use.

    METHODS, COMPOSITIONS, AND DEVICES FOR DRUG / LIVE CELL MICROARRAYS
    4.
    发明申请
    METHODS, COMPOSITIONS, AND DEVICES FOR DRUG / LIVE CELL MICROARRAYS 审中-公开

    公开(公告)号：US20190046479A1

    公开(公告)日：2019-02-14

    申请号：US16156949

    申请日：2018-10-10

    申请人： Pathak Holdings LLC

    发明人： Chandrashekhar P. Pathak

    IPC分类号： A61K31/155 ,  A61M37/00 ,  A61K31/7036 ,  A61K31/496 ,  A61K9/00 ,  A61K47/34 ,  A61K41/00 ,  A61K9/16 ,  A61L27/54 ,  A61L27/50 ,  A61K31/727 ,  A61K31/337

    摘要： Methods and compositions are for preparing microimplant arrays for sustained drug delivery or live cell based therapy. The “array in array” (AIA) device enables formation of microimplant arrays without having tissue piercing elements to the microimplant. The methods and compositions are for solid state delivery of drugs, especially biologics drugs without forming a drug solution prior to injection. New methods and compositions are for preparing in situ arrays for sustained drug delivery or live cell based therapy. Tissue surface is first treated with laser drilling, microneedle array, mechanical drilling or other methods to create artificial micro-porosity of various sizes, shapes and patterns. The artificial pores created are then infused with sustained drug delivery compositions or live cell suspensions. The compositions are converted into solid or semisolid state by physical or chemical reaction/s to entrap drug or live cells. The entrapped drug or live cells provide local or systemic therapeutic benefit.

    COMPOSITIONS, METHODS AND DEVICES FOR LOCAL DRUG DELIVERY
    5.
    发明申请
    COMPOSITIONS, METHODS AND DEVICES FOR LOCAL DRUG DELIVERY 审中-公开
    用于局部药物递送的组合物，方法和装置

    公开(公告)号：US20150359896A1

    公开(公告)日：2015-12-17

    申请号：US14736007

    申请日：2015-06-10

    申请人： Pathak Holdings, LLC

    发明人： Chandrashekhar P. Pathak

    IPC分类号： A61K47/34 ,  A61K31/496 ,  A61K31/7036 ,  A61K9/00

    CPC分类号： A61K47/34 ,  A61K9/0021 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/155 ,  A61K31/337 ,  A61K31/496 ,  A61K31/7036 ,  A61K31/727 ,  A61L31/16 ,  A61M5/3015 ,  A61M37/0076 ,  A61M2037/0023 ,  A61M2205/3606 ,  A61M2205/3653

    摘要： This invention provide novel compositions, methods and devices for sustained drug delivery. The microencapsulated sustained drug delivery compositions are deposited using oscillating needle apparatus oscillating at 10-12000 minutes per minutes. The injected compositions may undergo variety of physical chemical changes upon deposition. The physical and chemical changes enables improved drug encapsulation and sustained drug release. Also described are new methods to form polymer microparticles or polymer films/implants in situ inside the tissue. The invention also describes colored biodegradable microparticle based compositions wherein the compositions comprise drug encapsulated microparticles and coloring agent encapsulated microparticles mixed in any proportion. Medical applications of the compositions and methods described in this invention are also described.

    摘要翻译： 本发明提供用于持续给药的新型组合物，方法和装置。 使用以每分钟10-12000分钟振荡的摆动针装置沉积微囊化的持续药物递送组合物。 注入的组合物可能在沉积时经历各种物理化学变化。 物理和化学变化可以改善药物包封和持续的药物释放。 还描述了在组织内原位形成聚合物微粒或聚合物膜/植入物的新方法。 本发明还描述了着色的可生物降解的基于微粒的组合物，其中组合物包含药物封装的微粒和以任何比例混合的着色剂包封的微粒。 还描述了本发明中描述的组合物和方法的医学应用。

    DEVICE FOR FILLING FLESHY FRUITS AND VEGETABLES
    6.
    发明申请
    DEVICE FOR FILLING FLESHY FRUITS AND VEGETABLES 审中-公开
    用于灌装水果和蔬菜的装置

    公开(公告)号：US20140224134A1

    公开(公告)日：2014-08-14

    申请号：US14258695

    申请日：2014-04-22

    申请人： PATHAK HOLDINGS, LLC

    发明人： Chandrashekhar P. Pathak ,  Nivedita C. Pathak

    IPC分类号： A23P1/08

    CPC分类号： A23P20/25 ,  A23L19/05 ,  A23L33/115 ,  A23N4/12

    摘要： Systems and methods for filling a fleshy fruit or vegetable with a filler are described. Embodiments include tool having an expandable member that is expandable to an expanded position to make a cavity in the fruit and collapsible to a collapsed position for withdrawal from the fruit, with the expandable member in the expanded state comprising a cross-section that is larger than the maximum diameter of the tool in the collapsed position. A cavity may be created without substantially affecting the natural visual appearance of the fruit or vegetable. Fillers and filling methods are disclosed.

    摘要翻译： 描述了用填充物填充肉质水果或蔬菜的系统和方法。 实施例包括具有可膨胀构件的工具，该可膨胀构件可膨胀到膨胀位置以在水果中形成空腔并且可收缩到收缩位置以从果实中取出，而膨胀状态中的可膨胀构件包括大于 在折叠位置的刀具的最大直径。 可以创建空腔而基本上不影响水果或蔬菜的自然视觉外观。 公布了填料和填充方法。