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51 条记录 (耗时 0.041 秒)

    Melanocortin-1 Receptor-Specific Linear Peptides
    8.
    发明申请
    Melanocortin-1 Receptor-Specific Linear Peptides 审中-公开

    公开(公告)号：US20170145056A1

    公开(公告)日：2017-05-25

    申请号：US15422850

    申请日：2017-02-02

    申请人： Palatin Technologies, Inc.

    发明人： Wei Yang ,  Yi-Qun Shi

    IPC分类号： C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/68 ,  Y02A50/401

    摘要： Melanocortin receptor-specific linear peptides of the formula Z-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Y   (VI) or a pharmaceutically acceptable salt thereof, where Z, Y, Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, and Xaa6 are as defined in the specification, compositions and formulations including peptides of the foregoing formula or salts thereof, and pharmaceutical compositions for preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.

    Pyrrolidine melanocortin-specific compounds
    9.
    发明申请
    Pyrrolidine melanocortin-specific compounds 有权
    吡咯烷黑皮质素特异性化合物

    公开(公告)号：US20040167201A1

    公开(公告)日：2004-08-26

    申请号：US10776657

    申请日：2004-02-10

    申请人： Palatin Technologies, Inc.

    发明人： Shubh D. Sharma ,  Yi-Qun Shi ,  Zhijun Wu ,  Ramesh Rajpurohit

    IPC分类号： A61K038/04 ,  A61K031/4025 ,  A61K031/401

    CPC分类号： C07D487/04 ,  A61K38/12 ,  C07D207/16 ,  C07D241/04 ,  C07D241/08 ,  C07D317/72 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D417/12 ,  C07K5/0202 ,  C07K5/021 ,  C07K5/06078 ,  C07K5/06191 ,  C07K5/081 ,  C07K5/0821 ,  C07K5/0823 ,  C07K5/0827 ,  C07K5/1008 ,  C07K5/101 ,  G06F19/16 ,  G06F19/706

    摘要： Melanocortin receptor-specific pyrrolidine compounds having the structure: 1 and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in the specification, preferably where R3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R3 optionally further includes an amine capping group or from one to three additional amino acid residues, optionally with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.

    摘要翻译： 具有以下结构的黑皮质素受体特异性吡咯烷化合物及其立体异构体和药学上可接受的盐，其中R 1，R 2和R 3如说明书中所述，优选其中R 3是具有至少一个取代或未取代的苯基的D-氨基酸或 并且其中R 3任选地进一步包括胺封端基团或一至三个另外的氨基酸残基，任选地具有胺封端基团，所述化合物是一种或多种黑皮质素受体的激动剂，拮抗剂或混合激动剂和拮抗剂，以及 可用于治疗黑皮质素受体相关疾病和病症。 还公开了结构（I）化合物的合成方法，含有结构（I）化合物的药物组合物及其使用方法。