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    Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
    4.
    发明申请
    Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins 审中-公开
    用于诊断和治疗由朊病毒蛋白引起的疾病的复合肽化合物

    公开(公告)号：US20060057636A1

    公开(公告)日：2006-03-16

    申请号：US10525533

    申请日：2003-08-25

    申请人： Peter Heegaard ,  Palle Jakobsen

    发明人： Peter Heegaard ,  Palle Jakobsen

    IPC分类号： C07K14/775 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K47/64 ,  C07K16/18 ,  C07K19/00 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2800/2828

    摘要： The present invention relates to diseases caused by prion proteins, Novel composite peptide compounds are disclosed which comprise two or more peptides or peptide fragments optionally linked to a backbone and the peptides or peptide fragments are spatially positioned relative to each other so that they together form a non-linear sequence which mimics the tertiary structure of one or more PrPSc-specific epitopes as evidenced by the test described herein. The use of such conjugates as immunogens for the production of antibodies that specifically bind to the pathogenic form of a prion protein is revealed. Other uses of the composite peptide compounds are also disclosed, such as use in diagnostic assays, production of antibodies and uses as vaccine immunogens for the prophylactic protection and therapeutic treatment of subjects against transmissible prion disease.

    摘要翻译： 本发明涉及由朊病毒蛋白引起的疾病，公开了新的复合肽化合物，其包含两个或更多个肽或肽片段，任选地连接至主链，并且肽或肽片段相对于彼此在空间上定位，使得它们一起形成 模拟一种或多种PrP特异性表位的三级结构的非线性序列，如本文所述的测试所证明的。 揭示了使用这种缀合物作为免疫原用于产生特异性结合朊病毒蛋白的致病形式的抗体。 还公开了复合肽化合物的其它用途，例如用于诊断测定，抗体产生和用作疫苗免疫原用于受试者针对可传染性朊病毒疾病的预防性保护和治疗性治疗。

    Piperidine compounds and their preparation and use
    7.
    发明授权
    Piperidine compounds and their preparation and use 失效

    公开(公告)号：US5019582A

    公开(公告)日：1991-05-28

    申请号：US407237

    申请日：1989-09-14

    申请人： Jorgen Drejer ,  Palle Jakobsen

    发明人： Jorgen Drejer ,  Palle Jakobsen

    IPC分类号： A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P3/00 ,  C07D211/20 ,  C07D211/22 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D211/20 ,  C07D211/22

    摘要： Novel piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, C.sub.3-5 -alkylene or aralkoxy,R.sup.1 is straight or branched C.sub.1-8 -alkyl, C.sub.4-8 -alkoxy-C.sub.4-8 -alkyl, C.sub.4-7 -cycloalkyl, aryloxy-C.sub.3-8 -alkyl, C.sub.4-8 -alkenyl, or C.sub.4-8 -cycloalkylalkyl, or R.sup.1 may also be hydrogen or C.sub.1-3 -alkyl, when R.sup.3 is aryl, which is substituted with two or more of C.sub.1-6 - alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, aralkoxy, or with C.sub.3-5 -alkylene.X is hydrogen or halogen, and whereinY is O or Sor a salt thereof with a pharmaceutically-acceptable acid, pharmaceutical compositions thereof, method-of-treating therewith.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

    Piperidine compounds and pharmaceutical compositions thereof
    8.
    发明授权
    Piperidine compounds and pharmaceutical compositions thereof 失效
    哌啶化合物及其药物组合物

    公开(公告)号：US4985446A

    公开(公告)日：1991-01-15

    申请号：US486252

    申请日：1990-02-28

    申请人： Jorgen Drejer ,  Palle Jakobsen

    发明人： Jorgen Drejer ,  Palle Jakobsen

    IPC分类号： A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P3/00 ,  C07D211/20 ,  C07D211/22 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D211/20 ,  C07D211/22

    摘要： Novel piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, C.sub.3-5 -alkylene or aralkoxy,R.sup.1 is straight or branched C.sub.1-8 -alkyl, C.sub.4-8 -alkoxy-C.sub.4-8 -alkyl, C.sub.4-7 -cycloalkyl, aryloxy-C.sub.3-8 -alkyl, C.sub.4-8 -alkenyl, or C.sub.4-8 -cycloalkylalkyl, or R.sup.1 may also be hydrogen or C.sub.1-3 -alkyl, when R.sup.3 is aryl, which is substituted with two or more of C.sub.1-6 -alkyl, C.sub.1-6 alkoxy, C.sub.3-8 -cycloalkyl, aralkoxy, or with C.sub.3-5 -alkylene.X is hydrogen or halogen, and whereinY is O or Sor a salt thereof with a pharmaceutically-acceptable acid, pharmaceutical compositions thereof, method-of-treating therewith.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.