公开(公告)号：US20070149586A1

公开(公告)日：2007-06-28

申请号：US11678277

申请日：2007-02-23

申请人： Antonio Giordani ,  Antonino Santoro ,  Paolo Senin ,  Matteo Ghirri ,  Francesco Makovec ,  PaoLa Gilotta ,  Walter Peris ,  Lucio Claudio Rovati

发明人： Antonio Giordani ,  Antonino Santoro ,  Paolo Senin ,  Matteo Ghirri ,  Francesco Makovec ,  PaoLa Gilotta ,  Walter Peris ,  Lucio Claudio Rovati

IPC分类号： A61K31/41 ,  C07D403/02

CPC分类号： C07D257/04

摘要： Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A is a not hygroscopic solid, surprisingly stable to several humidity conditions in a temperature range acceptable for ordinary storage conditions. In addition its stability allows both chemical manufacturing and pharmaceutical manufacturing process consistency and reproducibility under conditions more viable and less expensive when compared to those used for highly hygroscopic solids.

摘要翻译： 描述了一种新型的Andolast二钠盐晶体A，三斜晶系，在98-112℃显示热事件，并在约400℃下分解熔融（DSC）。 A型固体二钠是一种不吸湿的固体，对于普通储存条件可接受的温度范围，在几种湿度条件下令人惊奇地稳定。 此外，与用于高吸湿性固体的那些相比，稳定性允许化学制造和药物制造过程在条件更加可行和更便宜的条件下的一致性和再现性。

公开(公告)号：US07824710B2

公开(公告)日：2010-11-02

申请号：US11678277

申请日：2007-02-23

申请人： Antonio Giordani ,  Antonino Santoro ,  Paolo Senin ,  Matteo Ghirri ,  Francesco Makovec ,  Paola Gilotta ,  Walter Peris ,  Lucio Claudio Rovati

发明人： Antonio Giordani ,  Antonino Santoro ,  Paolo Senin ,  Matteo Ghirri ,  Francesco Makovec ,  Paola Gilotta ,  Walter Peris ,  Lucio Claudio Rovati

IPC分类号： A61K9/14 ,  A61K31/41 ,  C07D207/00

CPC分类号： C07D257/04

摘要： Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A is a not hygroscopic solid, surprisingly stable to several humidity conditions in a temperature range acceptable for ordinary storage conditions. In addition its stability allows both chemical manufacturing and pharmaceutical manufacturing process consistency and reproducibility under conditions more viable and less expensive when compared to those used for highly hygroscopic solids.

摘要翻译： 描述了一种新型的Andolast二钠盐晶体A，三斜晶系，在98-112℃显示热事件，并在约400℃下分解熔融（DSC）。 A型固体二钠是一种不吸湿的固体，对于普通储存条件可接受的温度范围，在几种湿度条件下令人惊奇地稳定。 此外，与用于高吸湿性固体的那些相比，稳定性允许化学制造和药物制造过程在条件更加可行和更便宜的条件下的一致性和再现性。

公开(公告)号：US20110086896A1

公开(公告)日：2011-04-14

申请号：US12889897

申请日：2010-09-24

申请人： Antonio GIORDANI ,  Antonino SANTORO ,  Paolo SENIN ,  Matteo GHIRRI ,  Francesco MAKOVEC ,  Paola GILOTTA ,  Walter PERIS ,  Lucio Claudio ROVATI

发明人： Antonio GIORDANI ,  Antonino SANTORO ,  Paolo SENIN ,  Matteo GHIRRI ,  Francesco MAKOVEC ,  Paola GILOTTA ,  Walter PERIS ,  Lucio Claudio ROVATI

IPC分类号： A61K31/41 ,  A61P11/00 ,  A61P11/06

CPC分类号： C07D257/04

摘要： Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A is a not hygroscopic solid, surprisingly stable to several humidity conditions in a temperature range acceptable for ordinary storage conditions. In addition its stability allows both chemical manufacturing and pharmaceutical manufacturing process consistency and reproducibility under conditions more viable and less expensive when compared to those used for highly hygroscopic solids.

摘要翻译： 描述了一种新型的Andolast二钠盐晶体A，三斜晶系，在98-112℃显示热事件，并在约400℃下分解熔融（DSC）。 A型固体二钠是一种不吸湿的固体，对于普通储存条件可接受的温度范围，在几种湿度条件下令人惊奇地稳定。 此外，与用于高吸湿性固体的那些相比，稳定性允许化学制造和药物制造过程在条件更加可行和更便宜的条件下的一致性和再现性。