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公开(公告)号：US09861779B1
公开(公告)日：2018-01-09
申请号：US15188830
申请日：2016-06-21
CPC分类号： A61M16/20 , A61M16/0006 , A61M39/20 , A61M2039/205 , A61M2205/0205 , A61M2205/0238 , A61M2205/59
摘要： An improved oscillating positive expiratory pressure (“OPEP”) device, for respiratory therapy having a self sterilizing flow valve capable of insertion into the curved OPEP body without tools or aids. The flow valve is also tear resistant and incorporates a flared reinforced proximal end. To maximize the benefit to patients, the adjustable therapy selector is constrained from withdrawal and is dimensioned to accept commercially available, standardized respiratory fittings adaptors, mouthpieces and “Tees” that are capable of connection to multiple respiratory therapy devices or medicated aerosol delivery units. The aesthetics have been altered by the addition of an arced handle.
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2.发明授权公开(公告)号：US08041279B2
公开(公告)日：2011-10-18
申请号：US12273134
申请日：2008-11-18
申请人： Nicholas P. Kladias , Gerald A. Domoto , Santokh Badesha , Louis Fratangelo , Patrick Finn , Robert Pawlik
发明人： Nicholas P. Kladias , Gerald A. Domoto , Santokh Badesha , Louis Fratangelo , Patrick Finn , Robert Pawlik
IPC分类号： G03G15/20
CPC分类号： G03G15/2042
摘要： An iso-thermalizing printer structure can be used to provide temperature uniformity across a width of a printer fuser roll or fuser belt. Various embodiments are contemplated, including a solid natural graphite shaft, a solid natural graphite core having a sleeve of metal such as aluminum, and other flexible and rigid structures which can comprise natural or synthetic graphite.
摘要翻译： 可以使用均热打印机结构来提供打印机定影辊或定影带宽度上的温度均匀性。 包括固体天然石墨轴，具有诸如铝的金属套的固体天然石墨芯以及可包含天然或合成石墨的其它柔性和刚性结构的各种实施方案。
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公开(公告)号：US06600028B1
公开(公告)日：2003-07-29
申请号：US09402048
申请日：2000-02-01
申请人： Daniel Brown , David Loakes , David Williams , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall , Alan Hamilton , Clifford Smith , Adrian Christopher Simmonds , William Jonathan Cummins , Patrick Finn
发明人： Daniel Brown , David Loakes , David Williams , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall , Alan Hamilton , Clifford Smith , Adrian Christopher Simmonds , William Jonathan Cummins , Patrick Finn
IPC分类号： C07H2100
CPC分类号： C07D498/16 , C07H19/04 , C07H21/00
摘要： Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R8, X is O or N or NR12 or CR10, X′ is O or S or N, provided that when X′ is O or S, then X is C, Y is CH or N, R6 is NH2 or SMe or SO2Me or NHNH2, each of R7 and R8 is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R12 is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R10 is H or ═O or F or alkyl or aryl or a reporter moiety.
摘要翻译： 核苷类似物具有结构（2），其中Q是H或糖部分或糖类似物或修饰的糖或核心或骨架类似物，W是0-5个碳原子的亚烷基或亚烯基链，其中任何一个可携带 取代基R8，X为O或N或NR12或CR10，X'为O或S或N，条件是当X'为O或S时，则X为C，Y为CH或N，R6为NH2或SMe或SO2Me 或NHNH 2，R 7和R 8各自独立地为H或F，或烷基或链烯基或芳基或酰基或报道部分，R 12独立地为H或烷基或链烯基或芳基或酰基或报道部分，R 10为H或= O 或F或烷基或芳基或报道部分。
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公开(公告)号：US10328218B2
公开(公告)日：2019-06-25
申请号：US15147121
申请日：2016-05-05
摘要： A nebulizer system includes a body having a fluid chamber and an aerosol chamber, and a vibrator assembly positioned at an interface between the fluid chamber and the aerosol chamber. The vibrator assembly may include a diaphragm, having a fluid side and an aerosol side, defining a plurality of perforations between the fluid side and the aerosol side, and one or more vibrator elements operatively associated with the diaphragm to vibrate the diaphragm to produce aerosolized medicament projected into the aerosol chamber from the plurality of perforations. Each perforation of the plurality of perforations projects the aerosolized medicament along a respective projection path relative to a plane defined by the aerosol side of the perforation, the one or more vibrator elements or the diaphragm support substrate further being configured to angularly displace the aerosol side of the diaphragm to sweep the direction of at least one projection path.
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公开(公告)号：US20170361056A1
公开(公告)日：2017-12-21
申请号：US15188830
申请日：2016-06-21
CPC分类号： A61M16/20 , A61M16/0006 , A61M39/20 , A61M2039/205 , A61M2205/0205 , A61M2205/0238 , A61M2205/59
摘要： An improved oscillating positive expiratory pressure (“OPEP”) device, for respiratory therapy having a self sterilizing flow valve capable of insertion into the curved OPEP body without tools or aids. The flow valve is also tear resistant and incorporates a flared reinforced proximal end. To maximize the benefit to patients, the adjustable therapy selector is constrained from withdrawal and is dimensioned to accept commercially available, standardized respiratory fittings adaptors, mouthpieces and “Tees” that are capable of connection to multiple respiratory therapy devices or medicated aerosol delivery units. The aesthetics have been altered by the addition of an arced handle.
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公开(公告)号：US20170106155A1
公开(公告)日：2017-04-20
申请号：US15147121
申请日：2016-05-05
CPC分类号： A61M15/0091 , A61M11/00 , A61M11/005 , A61M15/0015 , A61M15/0018 , A61M15/0065 , A61M15/0085 , A61M15/0086 , A61M2016/0021 , A61M2016/0027 , A61M2205/3331 , A61M2205/3375 , A61M2205/3569 , A61M2205/3576 , A61M2205/3584 , A61M2205/505 , A61M2230/40
摘要： A nebulizer system includes a body having a fluid chamber and an aerosol chamber, and a vibrator assembly positioned at an interface between the fluid chamber and the aerosol chamber. The vibrator assembly may include a diaphragm, having a fluid side and an aerosol side, defining a plurality of perforations between the fluid side and the aerosol side, and one or more vibrator elements operatively associated with the diaphragm to vibrate the diaphragm to produce aerosolized medicament projected into the aerosol chamber from the plurality of perforations. Each perforation of the plurality of perforations projects the aerosolized medicament along a respective projection path relative to a plane defined by the aerosol side of the perforation, the one or more vibrator elements or the diaphragm support substrate further being configured to angularly displace the aerosol side of the diaphragm to sweep the direction of at least one projection path.
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公开(公告)号：US20110300120A1
公开(公告)日：2011-12-08
申请号：US13140272
申请日：2009-12-11
申请人： Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
发明人： Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
摘要： Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
摘要翻译： 本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。 本文还提供了包含这种缀合物的药物组合物。 本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。
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公开(公告)号：US07691446B2
公开(公告)日：2010-04-06
申请号：US11879153
申请日：2007-07-16
IPC分类号： B05D3/02
CPC分类号： G03G15/2057 , Y10T428/1386 , Y10T428/139 , Y10T428/249974 , Y10T428/254 , Y10T428/3154 , Y10T428/31663
摘要： This is a process to restore compression set properties of a silicone rubber fuser structure that has been damaged during the coating of the silicone with Teflon; Teflon is a registered trademark of DuPont. This restoration is achieved by re-baking the coated fuser roll at temperatures of 175° C. to 275° C. This will improve the compression set and will give the fuser structure improved life and provide better image quality.
摘要翻译： 这是恢复在用特氟龙涂覆硅树脂期间已经损坏的硅橡胶定影结构的压缩变形特性的过程; 特氟隆是杜邦的注册商标。 这种恢复是通过在175℃至275℃的温度下重新烘烤涂覆的定影辊来实现的。这将改善压缩变形，并且将使定影结构改善寿命并提供更好的图像质量。
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公开(公告)号：US20100048580A1
公开(公告)日：2010-02-25
申请号：US12610954
申请日：2009-11-02
申请人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , Wiliam Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , Wiliam Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/501 , C07D403/06 , C07D413/14 , C07D403/14 , C07D401/14 , A61K31/506 , A61K31/4439 , A61K31/4245 , A61K31/4025
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法
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公开(公告)号：US08835614B2
公开(公告)日：2014-09-16
申请号：US13140272
申请日：2009-12-11
申请人： Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
发明人： Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
摘要： Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
摘要翻译： 本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。 本文还提供了包含这种缀合物的药物组合物。 本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。
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