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1.发明授权Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents 失效已知和选择的可用作抗过敏剂和抗炎剂的噻唑烷酮，咪唑烷酮和恶唑烷酮的新型芳基亚甲基衍生物
公开(公告)号：US5208250A
公开(公告)日：1993-05-04
申请号：US702132
申请日：1991-05-13
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明涉及选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性。
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公开(公告)号：US4868205A
公开(公告)日：1989-09-19
申请号：US167272
申请日：1988-03-11
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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公开(公告)号：US4868199A
公开(公告)日：1989-09-19
申请号：US167264
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04 , C07D491/048
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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4.发明授权
公开(公告)号：US4761424A
公开(公告)日：1988-08-02
申请号：US782623
申请日：1985-10-01
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D491/048 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/12 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/68 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/60 , C07D333/64 , C07D333/68 , C07D333/70 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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5.发明授权Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents 失效酸性四唑基取代的吲哚化合物及其作为抗过敏剂的用途
公开(公告)号：US4675332A
公开(公告)日：1987-06-23
申请号：US788111
申请日：1985-10-21
IPC分类号： A61K31/41 , A61P9/00 , A61P25/04 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/42 , C07D403/04 , C07D403/12 , C07D405/14 , C07D491/056
CPC分类号： C07D403/04 , C07D209/42 , C07D403/12
摘要： Novel acidic indole compounds having use as antiallergic agents, methods of synthesis, compositions, and uses are claimed.
摘要翻译： 用作抗变应性剂的新型酸性吲哚化合物，合成方法，组合物和用途被要求保护。
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公开(公告)号：US4188326A
公开(公告)日：1980-02-12
申请号：US890544
申请日：1978-03-20
申请人： Richard E. Brown , Paul C. Unangst
发明人： Richard E. Brown , Paul C. Unangst
IPC分类号： C07D209/36 , C07D491/052 , C07D491/04
CPC分类号： C07D209/36 , Y10S514/826
摘要： This invention relates to novel substituted indolopyrones which have utility in preventing allergic and asthmatic reactions in mammals.
摘要翻译： 本发明涉及可用于预防哺乳动物过敏和哮喘反应的新型取代的吲哚吡酮。
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公开(公告)号：US4110464A
公开(公告)日：1978-08-29
申请号：US772036
申请日：1977-02-25
申请人： Richard E. Brown , Paul C. Unangst
发明人： Richard E. Brown , Paul C. Unangst
IPC分类号： C07D209/36 , C07D491/052 , A61K31/40
CPC分类号： C07D209/36 , Y10S514/826
摘要： This invention relates to novel substituted indolopyrones which have utility in preventing allergic and asthmatic reactions in mammals.
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公开(公告)号：US07244763B2
公开(公告)日：2007-07-17
申请号：US10774260
申请日：2004-02-06
申请人： Larry D. Bratton , Xue-Min Cheng , Noe Erasga , Gary F. Filzen , Andrew G. Geyer , Chitase Lee , Bharat K. Trivedi , Paul C. Unangst
发明人： Larry D. Bratton , Xue-Min Cheng , Noe Erasga , Gary F. Filzen , Andrew G. Geyer , Chitase Lee , Bharat K. Trivedi , Paul C. Unangst
IPC分类号： A61K31/235 , A61K31/38 , A61K31/35 , C07D405/00 , C07D261/06
CPC分类号： C07D213/74 , C07C59/72 , C07C62/34 , C07C323/20 , C07C323/21 , C07C323/22 , C07C323/25 , C07C323/62 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D213/34 , C07D215/36 , C07D261/08 , C07D263/57 , C07D263/58 , C07D307/79 , C07D311/58 , C07D333/22 , C07D333/60 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.
摘要翻译： 本发明涉及改变PPAR活性的化合物。 本发明还涉及化合物的药学上可接受的盐，包含该化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防哺乳动物血脂异常，高胆固醇血症，肥胖症，高血糖症，动脉粥样硬化，高甘油三酯血症和高胰岛素血症的治疗剂的方法 。 本发明还涉及制备所公开的化合物的方法。
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9.发明授权Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of HIV 失效苯并噻吩，苯并呋喃和吲哚 - 噻吩酮，氧氮杂酮和二氮杂酮作为细胞粘附的抑制剂和HIV的抑制剂
公开(公告)号：US5565446A
公开(公告)日：1996-10-15
申请号：US444975
申请日：1995-05-19
IPC分类号： C07D487/04 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P29/00 , A61P31/12 , A61P37/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D495/04 , A61K31/551 , A61K31/553 , A61K31/554 , C07D513/04
摘要： Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compounds also inhibit the activation of human immunodeficiency virus (HIV).
摘要翻译： 苯并噻吩，苯并呋喃和吲哚噻嗪酮，氧氮杂酮和二氮杂酮及其制备方法被描述为抑制白细胞粘附于血管内皮的药剂，因此是用于治疗炎性疾病的有效治疗剂; 这些化合物也抑制人体免疫缺陷病毒（HIV）的活化。
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公开(公告)号：US5489586A
公开(公告)日：1996-02-06
申请号：US351611
申请日：1994-12-12
IPC分类号： C07D487/04 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P29/00 , A61P31/12 , A61P37/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D495/04 , A61K31/551 , A61K31/553 , A61K31/554 , C07D513/04
摘要： Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases.
摘要翻译： 苯并噻吩，苯并呋喃和吲哚 - 硫氮酮，氧氮杂酮和二氮杂酮及其制备方法被描述为抑制白细胞粘附于血管内皮的试剂，因此是用于治疗炎性疾病的有效治疗剂。
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