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公开(公告)号：US08551044B2
公开(公告)日：2013-10-08
申请号：US12074570
申请日：2008-03-05
CPC分类号： A61M5/14276 , A61M5/1486 , A61M5/16809 , A61M5/16827
摘要： Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.
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公开(公告)号：US20100089487A1
公开(公告)日：2010-04-15
申请号：US12288659
申请日：2008-10-22
IPC分类号： B65B3/10
CPC分类号： A61M5/14276 , A61M5/1486 , A61M5/16809 , A61M5/16827
摘要： Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.
摘要翻译： 用于输送药物的多储器可植入阀蓄能器泵和输液输送方法。 该设备包括在公共压力室中的至少第一和第二输注储存器，每个与计量组件流体连通。 计量组件包括蓄能器，其优选地是具有入口和出口的固定容积蓄能器。 第一阀与第一输注储液器和储液器的入口流体连通，第二阀与第二输注储液器和储液器的入口流体连通。 出口阀与蓄能器的出口流体连通。 累积器可以依次从第一和第二输注储存器填充入口，可以连续多次从第一输注储存器连续多次填充第二输注储存器，或者连续地多次填充其中的任何组合或置换。
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公开(公告)号：US20090227989A1
公开(公告)日：2009-09-10
申请号：US12074570
申请日：2008-03-05
IPC分类号： A61K9/22
CPC分类号： A61M5/14276 , A61M5/1486 , A61M5/16809 , A61M5/16827
摘要： Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.
摘要翻译： 用于输送药物的多储器可植入阀蓄能器泵和输液输送方法。 该设备包括在公共压力室中的至少第一和第二输注储存器，每个与计量组件流体连通。 计量组件包括蓄能器，其优选地是具有入口和出口的固定容积蓄能器。 第一阀与第一输注储液器和储液器的入口流体连通，第二阀与第二输注储液器和储液器的入口流体连通。 出口阀与蓄能器的出口流体连通。 累积器可以依次从第一和第二输注储存器填充入口，可以连续地多次从第一输注储存器多次填充第二输注储存器，或者连续地多次填充其中的任何组合或置换。
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公开(公告)号：US06409698B1
公开(公告)日：2002-06-25
申请号：US09723057
申请日：2000-11-27
申请人： John N. Robinson , Paul F. Burke , Kenneth A. Fine
发明人： John N. Robinson , Paul F. Burke , Kenneth A. Fine
IPC分类号： D57
CPC分类号： A61M5/14276 , A61M5/172 , A61M31/002 , A61M39/0208 , A61M2005/14513 , A61M2205/3523 , A61M2205/3569 , A61N1/30
摘要： An electrodiffusion pump includes a housing having an inlet, drug reservoir, and outlet. A diffusion membrane is disposed between the reservoir and outlet for diffusing the drug outwardly therethrough. Internal and external electrodes are disposed on opposite sides of the membrane. The electrodes are porous, and the external electrode is additionally perforate to expose a portion of the membrane at the outlet. The electrodes are electrically powered for driving drug ions through the membrane under electrophoresis to complement diffusion thereof.
摘要翻译： 电扩散泵包括具有入口，药物储存器和出口的壳体。 扩散膜设置在储存器和出口之间，用于将药物向外扩散通过。 内部和外部电极设置在膜的相对侧上。 电极是多孔的，并且外部电极另外穿孔以在出口处暴露膜的一部分。 电极被电力驱动，以在电泳下驱动药物离子通过膜以补充其扩散。
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公开(公告)号：US08273058B2
公开(公告)日：2012-09-25
申请号：US11906826
申请日：2007-10-04
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译： 公开了一种用于输送药物的改进的可植入阀蓄能器泵。 可植入泵包括加压药物储存器。 药物计量组件包括位于一对阀之间的固定容积蓄积器。 阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。 为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。 该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。
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公开(公告)号：US5281210A
公开(公告)日：1994-01-25
申请号：US946848
申请日：1992-09-18
申请人： Paul F. Burke , Samir F. Idriss
发明人： Paul F. Burke , Samir F. Idriss
CPC分类号： A61M5/14276 , A61M5/16881
摘要： An accumulator for an implantable infusion system employs a pair of separated diaphragms movable in unison by a transfer fluid disposed therebetween. A first chamber receives infusate in metered amounts and dispenses the contents as a function of toggled valve operation. During filling, the first diaphragm deflects upward and by pressure transfer causes a corresponding deflection in the second diaphragm. The second diaphragm is biased by springs, gas under pressure or the like. Hence, when the outlet valve opens, the pressure differential across the diaphragm causes downward deflection. No mechanical stops are needed in the infusate chamber for the first diaphragm since its movement is controlled by the pressure differential across the second diaphragm.
摘要翻译： 用于植入式输注系统的蓄能器采用一对分离的隔膜，其可通过设置在其间的输送流体一致地移动。 第一腔室以计量量接收输液，并将内容物分配为切换阀门操作的功能。 在填充期间，第一隔膜向上偏转并且通过压力传递引起第二隔膜中相应的偏转。 第二隔膜由弹簧，气体在压力下等施加偏压。 因此，当出口阀打开时，横跨隔膜的压力差导致向下偏转。 在第一隔膜的输注腔室中不需要机械止动件，因为其运动由跨过第二隔膜的压力差来控制。
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公开(公告)号：US20130023857A1
公开(公告)日：2013-01-24
申请号：US13608583
申请日：2012-09-10
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
IPC分类号： A61M5/142
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译： 公开了一种用于输送药物的改进的可植入阀蓄能器泵。 可植入泵包括加压药物储存器。 药物计量组件包括位于一对阀之间的固定容积蓄积器。 阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。 为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。 该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。
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公开(公告)号：US08545477B2
公开(公告)日：2013-10-01
申请号：US12288659
申请日：2008-10-22
CPC分类号： A61M5/14276 , A61M5/1486 , A61M5/16809 , A61M5/16827
摘要： Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.
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公开(公告)号：US20090093797A1
公开(公告)日：2009-04-09
申请号：US11906826
申请日：2007-10-04
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译： 公开了一种用于输送药物的改进的可植入阀蓄能器泵。 可植入泵包括加压药物储存器。 药物计量组件包括位于一对阀之间的固定容积蓄积器。 阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。 为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。 该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。
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公开(公告)号：US06764472B1
公开(公告)日：2004-07-20
申请号：US09481298
申请日：2000-01-11
申请人： Paul F. Burke , Kenneth A. Fine
发明人： Paul F. Burke , Kenneth A. Fine
IPC分类号： A61M3100
CPC分类号： A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M2209/045
摘要： An implantable infusion device includes a lightweight, inert housing which contains an infusate for administration to a patient, and an enclosed, gas-impermeable variable volume chamber which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery. The lightweight housing may include integrally formed needle stops and suture fastening loops.
摘要翻译： 植入式输注装置包括轻量级的惰性壳体，其包含用于给患者施用的输液器，以及包含压力源（例如推进剂，机械弹簧等）的封闭的气体不可渗透的可变体积腔室。 可变体积室可以是刚性可膨胀波纹管结构或不可拉伸柔性袋的形式，并且附接到壳体，以便不妨碍用于引入输注物的入口。 响应于可变体积腔室相对于壳体中的输注体积的膨胀，通过导管从装置输送输注液。 提供单独的推注注射口，其允许输注物被直接导入导管并且覆盖受控的压力驱动输送。 轻便的外壳可以包括一体形成的针止动件和缝线紧固环。
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