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    Genetic suppression and replacement
    1.
    发明申请
    Genetic suppression and replacement 审中-公开

    公开(公告)号：US20060128648A1

    公开(公告)日：2006-06-15

    申请号：US11224524

    申请日：2005-09-12

    申请人： Gwenyth Farrar ,  Peter Humphries ,  Paul Kenna

    发明人： Gwenyth Farrar ,  Peter Humphries ,  Paul Kenna

    IPC分类号： A61K48/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  A61K48/005 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/15 ,  C12N2310/3181

    摘要： A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of: 1. providing suppressing nucleic acids or other suppression effectors able to bind to an endogenous gene, gene transcript or gene product to be suppressed and 2. providing genomic DNA or cDNA (complete or partial) encoding a replacement gene wherein the suppressing nucleic acids are unable to bind to equivalent regions in the genomic DNA or cDNA to prevent expression of the replacement gene. The replacement nucleic acids have modifications in one or more third base (wobble) positions such that replacement nucleic acids still code for the wild type or equivalent amino acids.