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公开(公告)号：US20110053796A1
公开(公告)日：2011-03-03
申请号：US12988106
申请日：2009-04-16
申请人： Paul Ko Ferrigno , Elisenda Gendra
发明人： Paul Ko Ferrigno , Elisenda Gendra
CPC分类号： C07K14/8139
摘要： The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.
摘要翻译： 本发明提供用于显示肽的新型支架蛋白，例如肽适体。 新型支架蛋白是Stefin A或STM（Stefin A的变体）的修饰，可用作支架蛋白和显示系统。
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公开(公告)号：US08853131B2
公开(公告)日：2014-10-07
申请号：US12988106
申请日：2009-04-16
申请人： Paul Ko Ferrigno , Elisenda Gendra
发明人： Paul Ko Ferrigno , Elisenda Gendra
CPC分类号： C07K14/8139
摘要： The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.
摘要翻译： 本发明提供用于显示肽的新型支架蛋白，例如肽适体。 新型支架蛋白是Stefin A或STM（Stefin A的变体）的修饰，可用作支架蛋白和显示系统。
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公开(公告)号：US08063019B2
公开(公告)日：2011-11-22
申请号：US11917057
申请日：2006-06-08
CPC分类号： C07K14/8139 , C07K7/06 , C12N15/1044
摘要： The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.
摘要翻译： 本发明涉及使用Stefin A作为展示插入肽的支架蛋白，特别是其中Stefin A是人SteFen A.几种突变有利地在野生型stefin A序列中制成，以改善其作为支架 ; 优选地，Stefin A包含在Leu 73位点处的异源肽插入。 此外，优选地，支架蛋白包含V48D突变; 优选地，支架蛋白包含G4W突变。 优选地，所述支架包含Leu73，V48D和G4W突变。 本发明还涉及支架蛋白本身，特别是具有Leu73，V48D和G4W突变的stefin A多肽，如SEQ ID NO：1所示。本发明还涉及鉴定结合蛋白和肽A的方法 （RLNKPLPSLPV）及其在治疗酵母菌感染中的应用。
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4.发明申请Methods and Devices for Detecting Structural Changes in a Molecule Measuring Electrochemical Impedance 审中-公开用于检测测量电化学阻抗的分子中的结构变化的方法和装置公开(公告)号：US20100234234A1
公开(公告)日：2010-09-16
申请号：US12440832
申请日：2007-09-13
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00653 , B01J2219/00659 , B01J2219/00704 , B01J2219/00725
摘要： The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays.
摘要翻译： 本发明涉及一种检测分子中的结构变化的方法，所述分子附着于表面，所述表面是导电的，其中监测所述表面处的电化学阻抗的相位，并且其中相的变化 所述表面的电化学阻抗表示所述分子的结构的变化。 本发明还涉及制备具有分子的阵列的方法，所述分子例如附着到诸如电极的导电表面上的多肽，以及阵列。
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公开(公告)号：US08481491B2
公开(公告)日：2013-07-09
申请号：US13243318
申请日：2011-09-23
CPC分类号： C07K14/8139 , C07K7/06 , C12N15/1044
摘要： The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV, SEQ ID NO: 30) and its use in treating yeast infections.
摘要翻译： 本发明涉及使用Stefin A作为展示插入肽的支架蛋白，特别是其中Stefin A是人SteFen A.几种突变有利地在野生型stefin A序列中制成，以改善其作为支架 ; 优选地，Stefin A包含在Leu 73位点处的异源肽插入。 此外，优选地，支架蛋白包含V48D突变; 优选地，支架蛋白包含G4W突变。 优选地，所述支架包含Leu73，V48D和G4W突变。 本发明还涉及支架蛋白本身，特别是具有Leu73，V48D和G4W突变的stefin A多肽，如SEQ ID NO：1所示。本发明还涉及鉴定结合蛋白和肽A的方法 （RLNKPLPSLPV，SEQ ID NO：30）及其在治疗酵母菌感染中的应用。
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公开(公告)号：US20080207509A1
公开(公告)日：2008-08-28
申请号：US11917057
申请日：2006-06-08
CPC分类号： C07K14/8139 , C07K7/06 , C12N15/1044
摘要： The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.
摘要翻译： 本发明涉及使用Stefin A作为展示插入肽的支架蛋白，特别是其中Stefin A是人SteFen A.几种突变有利地在野生型stefin A序列中制成，以改善其作为支架 ; 优选地，Stefin A包含在Leu 73位点处的异源肽插入。 此外，优选地，支架蛋白包含V48D突变; 优选地，支架蛋白包含G4W突变。 优选地，所述支架包含Leu73，V48D和G4W突变。 本发明还涉及支架蛋白本身，特别是具有Leu73，V48D和G4W突变的stefin A多肽，如SEQ ID NO：1所示。本发明还涉及鉴定结合蛋白和肽A的方法 （RLNKPLPSLPV）及其在治疗酵母菌感染中的应用。
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公开(公告)号：US20120190819A1
公开(公告)日：2012-07-26
申请号：US13243318
申请日：2011-09-23
CPC分类号： C07K14/8139 , C07K7/06 , C12N15/1044
摘要： The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.
摘要翻译： 本发明涉及使用Stefin A作为展示插入肽的支架蛋白，特别是其中Stefin A是人SteFen A.几种突变有利地在野生型stefin A序列中制成，以改善其作为支架 ; 优选地，Stefin A包含在Leu 73位点处的异源肽插入。 此外，优选地，支架蛋白包含V48D突变; 优选地，支架蛋白包含G4W突变。 优选地，所述支架包含Leu73，V48D和G4W突变。 本发明还涉及支架蛋白本身，特别是具有Leu73，V48D和G4W突变的stefin A多肽，如SEQ ID NO：1所示。本发明还涉及鉴定结合蛋白和肽A的方法 （RLNKPLPSLPV）及其在治疗酵母菌感染中的应用。
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