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公开(公告)号：US20100075347A1
公开(公告)日：2010-03-25
申请号：US12375731
申请日：2007-08-15
IPC分类号： G01N33/569 , G01N33/543 , G01N33/554
CPC分类号： G01N29/022 , G01N27/725 , G01N33/54333 , G01N33/54373 , G01N2291/0255 , G01N2291/0256 , G01N2291/02863 , G01N2291/0422 , G01N2291/0423
摘要： Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by coupling of the target biological analyte (e.g., through the use of magnetic particles), application of a magnetic field to draw the target analyte to the sensor surface, and subsequent removal of the magnetic field before measuring detection.
摘要翻译： 公开了使用由传感器产生的声 - 机械能来检测样品材料内的目标生物分析物的方法。 声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。 通过将目标生物分析物（例如，通过使用磁性颗粒）的耦合，施加磁场以将目标分析物吸引到传感器表面，并随后将样品材料中的目标生物分析物除去 磁场测量前检测。
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公开(公告)号：US20110211991A1
公开(公告)日：2011-09-01
申请号：US13128093
申请日：2009-11-05
申请人： William E. Foltz , Chad M. Herrlein , Joshua M. Schmitz , Barry W. Robole , Kelvin J. Witcher , Paul N. Holt
发明人： William E. Foltz , Chad M. Herrlein , Joshua M. Schmitz , Barry W. Robole , Kelvin J. Witcher , Paul N. Holt
CPC分类号： A61L2/28
摘要： A sterilization process challenge device comprising a first container comprising walls which define a first space within the first container; a process indicator within the first space; at least one sterilant access for a sterilant to enter the first space within the first container; wherein at least one of the walls which defines the first space is a flexible wall; and wherein the walls are impervious to the sterilant; a method of using the device; and a kit including the device are disclosed.
摘要翻译： 一种灭菌过程挑战装置，包括：第一容器，其包含限定所述第一容器内的第一空间的壁; 第一空间内的过程指示器; 消毒剂进入第一容器内的第一空间的至少一种灭菌剂通路; 其中限定所述第一空间的壁中的至少一个是柔性壁; 并且其中所述壁对所述灭菌剂是不透水的; 使用该装置的方法; 并且公开了包括该装置的套件。
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公开(公告)号：US20100129878A1
公开(公告)日：2010-05-27
申请号：US12596346
申请日：2008-04-25
申请人： Ranjani V. Parthasarathy , Hsi-Chou Liu , Wensheng Xia , Assumpta Bennaars-Eiden , Paul N. Holt , William Bedingham , Christopher R. Kokaisel , Jeffrey C. Pederson
发明人： Ranjani V. Parthasarathy , Hsi-Chou Liu , Wensheng Xia , Assumpta Bennaars-Eiden , Paul N. Holt , William Bedingham , Christopher R. Kokaisel , Jeffrey C. Pederson
IPC分类号： C12P19/34
CPC分类号： B01L3/502753 , B01L7/52 , B01L2200/0647 , B01L2300/0806 , B01L2400/0677 , C12Q1/6806 , C12Q1/6846 , C12Q2563/149 , C12Q2563/137
摘要： The present invention provides methods for amplifying nucleic acid after isolating nucleic acid from a sample using functionalized support material.
摘要翻译： 本发明提供了使用官能化载体材料从样品中分离核酸后扩增核酸的方法。
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4.发明申请公开(公告)号：US20100062421A1
公开(公告)日：2010-03-11
申请号：US12597326
申请日：2008-04-25
CPC分类号： C12N15/1006 , G01N33/569
摘要： Compositions, methods, devices, and kits, which include an immobilized-metal support material comprising a substrate having a plurality of —C(O)O− or —P(O)(—OH)2-x(—O−)x groups bound to the substrate and a plurality of metal ions, My+, bound to the —C(O)O− or —P(O)(—OH)2-x(—O−)x groups; wherein M is selected from the group consisting of zirconium, gallium, iron, aluminum, scandium, titanium, vanadium, yttrium, and a lanthanide; y is an integer from 3 to 6; and x is 1 or 2, and to which microorganisms and polynucleotides bind, and which can be used for separating and optionally assaying microorganisms and/or a polynucleotide from a sample material are disclosed.
摘要翻译： 组合物，方法，装置和试剂盒，其包括固定金属载体材料，其包含具有多个-C（O）O-或-P（O）（-OH）2-x（-O-）x 结合到基底和与-C（O）O-或-P（O）（ - OH）2-x（-O-）x基团结合的多个金属离子My +的基团; 其中M选自锆，镓，铁，铝，钪，钛，钒，钇和镧系元素; y为3〜6的整数; 并且x为1或2，并且公开了微生物和多核苷酸结合，并且其可用于从样品材料分离和任选地测定微生物和/或多核苷酸。
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