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公开(公告)号:US20080102031A1
公开(公告)日:2008-05-01
申请号:US11960845
申请日:2007-12-20
申请人: Roland Dolle , Bertrand Le Bourdonnec , Christopher Ajello , Minghua Gu , Guo-Hua Chu , Paul Tuthill , Lara Leister , Q. Zhou
发明人: Roland Dolle , Bertrand Le Bourdonnec , Christopher Ajello , Minghua Gu , Guo-Hua Chu , Paul Tuthill , Lara Leister , Q. Zhou
IPC分类号: A61K47/00 , A61K31/407 , A61K31/4433 , A61K31/496 , A61P25/00 , A61P25/28 , A61P27/06 , A61P9/06 , C07D241/04 , C07D491/052 , C07D273/01 , C07D211/26 , A61P41/00 , A61P25/30 , A61P25/04 , A61P15/12 , A61K31/5355 , A61K31/55
CPC分类号: C07D491/107 , C07D221/20 , C07D311/96 , C07D401/04 , C07D493/10 , C07D495/10
摘要: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
摘要翻译: 公开了螺环杂环衍生物,含有这些化合物的药物组合物及其制药方法。 在某些实施方案中,螺环杂环衍生物是δ阿片受体受体的配体,尤其可用于治疗和/或预防疼痛,焦虑,胃肠道疾病和其他δ阿片受体介导的病症。
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公开(公告)号:US20050159438A1
公开(公告)日:2005-07-21
申请号:US10957554
申请日:2004-10-01
申请人: Roland Dolle , Bertrand Le Bourdonnec , Christopher Ajello , Minghua Gu , Guo-Hua Chu , Paul Tuthill , Lara Leister , Q. Zhou
发明人: Roland Dolle , Bertrand Le Bourdonnec , Christopher Ajello , Minghua Gu , Guo-Hua Chu , Paul Tuthill , Lara Leister , Q. Zhou
IPC分类号: A61K31/438 , A61K31/44 , A61K31/4747 , A61K31/55 , C07D20060101 , C07D401/04 , C07D471/10 , C07D491/10
CPC分类号: C07D491/107 , C07D221/20 , C07D311/96 , C07D401/04 , C07D493/10 , C07D495/10
摘要: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
摘要翻译: 公开了螺环杂环衍生物,含有这些化合物的药物组合物及其制药方法。 在某些实施方案中,螺环杂环衍生物是δ阿片受体受体的配体,尤其可用于治疗和/或预防疼痛,焦虑,胃肠道疾病和其他δ阿片受体介导的病症。
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