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公开(公告)号:US07465726B2
公开(公告)日:2008-12-16
申请号:US11194158
申请日:2005-08-01
申请人: Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , William Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo G. Steinig , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth (‘Ken’) Foreman , Qinghua (‘Felix’) Weng , Kathryn Stolz
发明人: Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , William Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo G. Steinig , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth (‘Ken’) Foreman , Qinghua (‘Felix’) Weng , Kathryn Stolz
IPC分类号: A61K31/437 , A61K31/496 , A61K31/5355 , A61K31/541 , A61K31/5513 , A61K31/551 , C07D471/04 , C07D223/04 , C07D243/08 , C07D241/04 , C07D413/10 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , A61K31/04 , A61K31/519 , C07D487/04
CPC分类号: C07D471/02 , C07D487/02 , C07D487/04
摘要: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译: 由式(I)表示的化合物或其立体异构体或其药学上可接受的盐是Abl,Aurora-A,Blk,c-Raf,cSRC,Src,PRK2,FGFR3,Flt3,Lck,Mek1,PDK中的至少两种的抑制剂 -1,GSK3beta,EGFR,p70S6K,BMX,SGK,CaMKII,Tie-2,IGF-1R,Ron,Ret和KDR激酶,用于治疗和/或预防各种疾病和病症, 癌症。
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公开(公告)号:US20070112005A1
公开(公告)日:2007-05-17
申请号:US11599663
申请日:2006-11-15
申请人: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
发明人: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
IPC分类号: A61K31/498 , A61K31/53 , C07D487/12
CPC分类号: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐是mTOR的抑制剂,可用于治疗癌症。
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公开(公告)号:US20070254883A1
公开(公告)日:2007-11-01
申请号:US11657156
申请日:2007-01-24
申请人: Andrew Crew , Douglas Werner , Paula Tavares
发明人: Andrew Crew , Douglas Werner , Paula Tavares
IPC分类号: A61K31/519 , A61K31/53 , A61P35/00 , C07D487/04
CPC分类号: C07D487/04
摘要: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐是mTOR的抑制剂,可用于治疗癌症。
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4.Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds 失效
标题翻译: 芳基 - 氨基取代的吡咯并嘧啶多激酶抑制化合物公开(公告)号:US20060211678A1
公开(公告)日:2006-09-21
申请号:US11194158
申请日:2005-08-01
申请人: Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , Wiliam Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo Steing , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth Foreman , Qinghua Weng , Kathryn Stolz
发明人: Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , Wiliam Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo Steing , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth Foreman , Qinghua Weng , Kathryn Stolz
IPC分类号: A61K31/5377 , A61K31/519 , A61K31/496 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号: C07D471/02 , C07D487/02 , C07D487/04
摘要: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译: 由式(I)表示的化合物或其立体异构体或其药学上可接受的盐是Abl,Aurora-A,Blk,c-Raf,cSRC,Src,PRK2,FGFR3,Flt3,Lck,Mek1,PDK中的至少两种的抑制剂 -1,GSK3beta,EGFR,p70S6K,BMX,SGK,CaMKII,Tie-2,IGF-1R,Ron,Ret和KDR激酶,用于治疗和/或预防各种疾病和病症, 癌症。
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