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公开(公告)号：US08652473B2
公开(公告)日：2014-02-18
申请号：US12657919
申请日：2010-01-29
申请人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
发明人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
IPC分类号： A61K39/395 , C12P21/08 , C07K16/00
摘要： The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
摘要翻译： 本发明一般涉及生长因子受体表位肽，特别是EGF家族受体表位肽。 本发明还涉及受体肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明还涉及特异性针对受体肽的抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。
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公开(公告)号：US07767792B2
公开(公告)日：2010-08-03
申请号：US11060646
申请日：2005-02-17
申请人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
发明人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
摘要： The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
摘要翻译： 本发明一般涉及生长因子受体表位肽，特别是EGF家族受体表位肽。 本发明还涉及受体肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明还涉及特异性针对受体肽的抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。
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公开(公告)号：US20100322937A1
公开(公告)日：2010-12-23
申请号：US12657919
申请日：2010-01-29
申请人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
发明人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
摘要： The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
摘要翻译： 本发明一般涉及生长因子受体表位肽，特别是EGF家族受体表位肽。 本发明还涉及受体肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明还涉及特异性针对受体肽的抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。
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