公开(公告)号：US20130295590A1

公开(公告)日：2013-11-07

申请号：US13885376

申请日：2011-11-08

Applicant: David Degraff ,  Robert Matusik ,  Peter Clark ,  Dan Theodorescu

Inventor： David Degraff ,  Robert Matusik ,  Peter Clark ,  Dan Theodorescu

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/57407 ,  G01N2333/4703 ,  G01N2800/52 ,  G01N2800/56

Abstract: The present invention provides for a proteomic approach to predicting, diagnosing and staging invasive bladder cancer, and for predicting patient survival and therapeutic efficacy. More specifically, the target being analyzed for reduced expression is FOXA1, and optionally including analysis of increased FOXA2 expression.

Abstract translation: 本发明提供了用于预测，诊断和分期侵袭性膀胱癌以及用于预测患者存活和治疗功效的蛋白质组学方法。 更具体地，被分析用于降低表达的靶是FOXA1，并且可选地包括增加的FOXA2表达的分析。

公开(公告)号：US07619096B2

公开(公告)日：2009-11-17

申请号：US10558626

申请日：2004-05-11

Applicant: Christopher David Beadle ,  Manuel Javier Cases-Thomas ,  Barry Peter Clark ,  Peter Thaddeus Gallagher ,  John Joseph Masters ,  Graham Henry Timms ,  Magnus Wilhelm Walter ,  Maria Ann Whatton ,  Virginia Ann Wood ,  Jeremy Gilmore

Inventor： Christopher David Beadle ,  Manuel Javier Cases-Thomas ,  Barry Peter Clark ,  Peter Thaddeus Gallagher ,  John Joseph Masters ,  Graham Henry Timms ,  Magnus Wilhelm Walter ,  Maria Ann Whatton ,  Virginia Ann Wood ,  Jeremy Gilmore

IPC: C07D207/00 ,  A61K31/40 ,  C07D295/00 ,  A01N43/36

CPC classification number: C07D207/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，其可用于抑制一种或多种生理活性单胺（5-羟色胺，去甲肾上腺素和多巴胺）摄取。

公开(公告)号：US07384941B2

公开(公告)日：2008-06-10

申请号：US10524650

申请日：2003-08-18

Applicant: Magnus Wilhelm Walter ,  Barry Peter Clark ,  Peter Thaddeus Gallagher ,  Helen Louise Haughton ,  Hélène Catherine Eugénie Rudyk

Inventor： Magnus Wilhelm Walter ,  Barry Peter Clark ,  Peter Thaddeus Gallagher ,  Helen Louise Haughton ,  Hélène Catherine Eugénie Rudyk

IPC: A61K31/5377 ,  C07D265/30

CPC classification number: C07D265/30

Abstract: Compounds of formula (I): wherein A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C1-C4 alkyl, a C3-C6 cycloalkyl group or a CH2(C3-C6 cycloalkyl) group; R′ is H or C1-C4 alkyl; and each R1 is independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof are selective inhibitors of norepinephrine reuptake.

Abstract translation: 式（I）的化合物：其中A是S或O; R为H; Ar是任选取代的苯基; X是任选取代的苯基，C 1 -C 4烷基，C 3 -C 6亚烷基， 环烷基或CH 2（C 3 -C 6环烷基）基团; R'是H或C 1 -C 4烷基; 且每个R 1独立地为H或C 1 -C 4烷基; 和其药学上可接受的盐是去甲肾上腺素再摄取的选择性抑制剂。

公开(公告)号：US07294623B2

公开(公告)日：2007-11-13

申请号：US10524798

申请日：2003-08-18

Applicant: Barry Peter Clark ,  Peter Thaddeus Gallagher ,  Helen Louise Haughton

Inventor： Barry Peter Clark ,  Peter Thaddeus Gallagher ,  Helen Louise Haughton

IPC: A61K31/5375 ,  C07D265/30

CPC classification number: C07D265/30

Abstract: A compound of formula (I) (I) wherein R is H; Ar is an aromatic group selected from phenyl; X is a phenyl group; R′ is H or C1-C4 alkyl; each R1 is independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof

Abstract translation: 式（I）（I）的化合物，其中R是H; Ar是选自苯基的芳基; X是苯基; R'是H或C 1 -C 4烷基; 每个R 1独立地为H或C 1 -C 4烷基; 及其药学上可接受的盐

公开(公告)号：US1883573A

公开(公告)日：1932-10-18

申请号：US48833030

申请日：1930-10-13

Applicant: PETER CLARK ,  GEORGE VAIL

Inventor： PETER CLARK ,  GEORGE VAIL

IPC: A63J1/02

CPC classification number: A63J1/02

公开(公告)号：US1809109A

公开(公告)日：1931-06-09

申请号：US47737630

申请日：1930-08-23

Applicant: PETER CLARK ,  PINGLE JERRY C

Inventor： PETER CLARK ,  PINGLE JERRY C

IPC: A47H5/14

CPC classification number: A47H5/14

公开(公告)号：US1732600A

公开(公告)日：1929-10-22

申请号：US30677228

申请日：1928-09-18

Applicant: PETER CLARK INC

Inventor： HARDING HOWARD V

IPC: F21S2/00 ,  F21S8/00

CPC classification number: F21S2/00 ,  F21W2131/406

公开(公告)号：US10067143B2

公开(公告)日：2018-09-04

申请号：US13695271

申请日：2011-04-28

Applicant: Jonathan Peter Clark

Inventor： Jonathan Peter Clark

IPC: G01N33/68 ,  C12Q1/37 ,  G01N33/542

CPC classification number: G01N33/6872 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2500/00

Abstract: The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBE1, UbcH3, Skp2-isoform 1, Skp1, Cull, Rbx1, Cks1, CDK2 and Cyclin E1 under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate.

公开(公告)号：US20150083374A1

公开(公告)日：2015-03-26

申请号：US14209387

申请日：2014-03-13

Applicant: J. Peter Clark, III

Inventor： J. Peter Clark, III

IPC: F25D17/02

CPC classification number: F25D17/02 ,  F25C2301/002

Abstract: A closed loop refrigeration system comprises an ice slurry mixture which comprises ice, water, and a freezing point depressant. The system also comprises a first storage device for storing the ice slurry mixture, and an agitator disposed in the first storage device. The agitator agitates the ice slurry mixture in at least an intermittent manner. The system further comprises a first conduit connecting the first storage device and a heat load, and a first pump disposed on the first conduit for pumping the ice slurry mixture through the first conduit from the first storage device to the heat load. At least some of the ice melts in the heat load. The system also comprises a second conduit connecting the heat load and a second storage device. The second storage device is connected to the first storage device. The system further comprises a second pump disposed on the second conduit for pumping the ice slurry mixture containing the melted ice through the second conduit from the heat load to the second storage device.

Abstract translation: 闭环制冷系统包括冰浆混合物，其包含冰，水和冰点降低剂。 该系统还包括用于储存冰浆混合物的第一储存装置和设置在第一储存装置中的搅拌器。 搅拌器以至少间歇的方式搅拌冰浆混合物。 该系统还包括连接第一存储装置和热负荷的第一导管以及设置在第一导管上的第一泵，用于将冰浆混合物从第一存储装置泵送到第一管道至热负荷。 至少有一些冰在热负荷中融化。 该系统还包括连接热负荷的第二导管和第二存储装置。 第二存储装置连接到第一存储装置。 该系统还包括设置在第二管道上的第二泵，用于将含有熔融冰的冰浆混合物通过第二导管从热负荷泵送到第二储存装置。

公开(公告)号：USD675613S1

公开(公告)日：2013-02-05

申请号：US29393433

申请日：2011-06-03

Applicant: Chao-Ming Chu ,  Peter Clark Timothy

Designer： Chao-Ming Chu ,  Peter Clark Timothy