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13 条记录 (耗时 0.024 秒)

    Method for the production of substituted trifluoroethylenes
    2.
    发明申请
    Method for the production of substituted trifluoroethylenes 审中-公开
    制备取代三氟乙烯的方法

    公开(公告)号：US20050222461A1

    公开(公告)日：2005-10-06

    申请号：US10514345

    申请日：2003-05-08

    申请人： Peter Wolfrum ,  Albrecht Marhold

    发明人： Peter Wolfrum ,  Albrecht Marhold

    IPC分类号： C07B35/06 ,  C07B61/00 ,  C07C17/00 ,  C07C17/23 ,  C07C17/383 ,  C07C21/18 ,  C07C51/377 ,  C07C51/44 ,  C07C57/52 ,  C07C231/12

    CPC分类号： C07C17/23 ,  C07B35/06 ,  C07C17/00 ,  C07C51/377 ,  C07C21/18 ,  C07C57/52

    摘要： The present invention relates to a method for the production of substituted trifluoroethylenes, in which a compound of the formula (II) in which R is C1-C6-alkyl optionally substituted by carboxyl, halogen, C1-C6-alkoxy, C1-C6-alkoxycarbonyl or C1-C4-alkylcarbonyloxy or is the grouping in which R′ and R″ are, independently of one another, hydrogen or C1-C6-alkyl or the two, together with the nitrogen atom to which they are bonded, are saturated cycloalkyl with 3 to 5 carbon atoms, in which a ring member is optionally replaced by oxygen or sulfur and which is optionally substituted by one to four C1-C4-alkyl, trifluoromethyl or C1-C4-alkoxy, and Hal is chlorine, bromine or iodine, preferably chlorine or bromine, is brought into contact with a dehalogenating agent in a water-comprising polar medium.

    摘要翻译： 本发明涉及一种制备取代三氟乙烯的方法，其中式（II）化合物其中R是C 1 -C 6 - 烷基任选地 被羧基，卤素，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷氧基羰基或C 1 -C 6 - C 1 -C 4 - 烷基羰基氧基，或者其中R'和R“彼此独立地是氢或C 1〜 -C 2 -C 6 - 烷基或两者与它们所键合的氮原子一起是具有3至5个碳原子的饱和环烷基，其中任选被氧或硫取代的环成员 并且其任选被一至四个C 1 -C 4 - 烷基，三氟甲基或C 1 -C 4烷基取代， SUB-烷氧基和Hal是氯，溴或碘，优选氯或溴，与含水的极性介质中的脱卤剂接触。

    Method for the production of substituted trifluroethylenses
    3.
    发明申请
    Method for the production of substituted trifluroethylenses 审中-公开
    取代三氟乙烯生产方法

    公开(公告)号：US20060052640A1

    公开(公告)日：2006-03-09

    申请号：US10514266

    申请日：2003-05-08

    申请人： Peter Wolfrum ,  Albrecht Marhold

    发明人： Peter Wolfrum ,  Albrecht Marhold

    IPC分类号： C07C17/25

    CPC分类号： C07C17/00 ,  C07B35/06 ,  C07C17/23 ,  C07C21/18

    摘要： The present invention relates to a method for the production of substituted trifluoroethylenes, in which a compound of the formula (II) in which R is C1-C6-alkyl optionally substituted by carboxyl, halogen, C1-C6-alkoxy, C1-C6-alkoxycarbonyl or C1-C4-alkylcarbonyloxy or is the grouping in which R′ and R″ are, independently of one another, hydrogen or C1-C6-alkyl or the two, together with the nitrogen atom to which they are bonded, are saturated cycloalkyl with 3 to 5 carbon atoms, in which a ring member is optionally replaced by oxygen or sulfur and which is optionally substituted by one to four C1-C4-alkyl, trifluoromethyl or C1-C4-alkoxy, and Hal is chlorine, bromine or iodine, is brought into contact with a dehalogenating agent in a polyol or its ethers.

    摘要翻译： 本发明涉及一种制备取代三氟乙烯的方法，其中式（II）化合物

    2,4-dichlodro-5-fluoro-1,3-dimethylybenzene
    8.
    发明授权
    2,4-dichlodro-5-fluoro-1,3-dimethylybenzene 有权
    2,4-二氯-5-氟-1,3-二甲基苯

    公开(公告)号：US06541675B2

    公开(公告)日：2003-04-01

    申请号：US09814132

    申请日：2001-03-21

    申请人： Albrecht Marhold ,  Peter Wolfrum

    发明人： Albrecht Marhold ,  Peter Wolfrum

    IPC分类号： C07C2513

    CPC分类号： C07C255/57 ,  C07C17/12 ,  C07C17/14 ,  C07C25/13 ,  C07C251/48 ,  G01C21/26 ,  G01C22/002

    摘要： The present invention relates to 3-cyano-2,4,5-trifluorobenzoyl fluoride and to intermediates for its preparation and to the process for the preparation of 3-cyano-2,4,5-trifluoro-benzoyl fluoride, which starts from 5-fluoro-1,3-xylene (VIII); which is bichlorinated in the ring in the presence of a catalyst under ionic conditions to give 2,4-dichloro-5-fluoro-1,3-dimethylbenzene (VII). The latter is chlorinated in the side chains under free-radical conditions to give 2,4-dichloro-5-fluoro-3-dichloromethyl-1-trichloromethylbenzene (VI). The latter is hydrolysed via 2,4-dichloro-5-fluoro-3-dichloromethylbenzoic acid (V), which can be isolated if necessary, to give 2,4-dichloro-5-fluoro-3-formyl-benzoic acid (IV), the aldehyde group of which is reacted to give 2,4-dichloro-5-fluoro-3-N-hydroxyiminomethyl-benzoic acid (III), from which, with simultaneous conversion of the carboxyl group into the chlorocarbonyl group, water is eliminated using an acid chloride to give the nitrile 2,4-dichloro-3-cyano-5-fluoro-benzoyl chloride (II). Finally, the nitrile is subjected to fluorine/chlorine exchange.

    摘要翻译： 本发明涉及3-氰基-2,4,5-三氟苯甲酰氟及其制备中间体以及制备3-氰基-2,4,5-三氟 - 苯甲酰氟的方法，其从5 - 氟-1,3-二甲苯（VIII）; 其在离子条件下在催化剂存在下在环中二氯化，得到2,4-二氯-5-氟-1,3-二甲基苯（VII）。 后者在自由基条件下在侧链中氯化，得到2,4-二氯-5-氟-3-二氯甲基-1-三氯甲基苯（VI）。 后者通过2,4-二氯-5-氟-3-二氯甲基苯甲酸（V）水解，如果需要可以分离，得到2,4-二氯-5-氟-3-甲酰基 - 苯甲酸（IV ），其醛基反应得到2,4-二氯-5-氟-3-N-羟基亚氨基甲基 - 苯甲酸（III），其中通过同时将羧基转化为氯羰基，水是 使用酰氯除去得到腈2,4-二氯-3-氰基-5-氟 - 苯甲酰氯（II）。 最后，腈进行氟/氯交换。

    3-cyano-2,4,5-trifluoro-benzoyl fluoride and intermediate products for the production thereof
    10.
    发明授权
    3-cyano-2,4,5-trifluoro-benzoyl fluoride and intermediate products for the production thereof 有权
    3-氰基-2,4,5-三氟 - 苯甲酰氟及其制备的中间产物

    公开(公告)号：US06229040B1

    公开(公告)日：2001-05-08

    申请号：US09403263

    申请日：1999-10-15

    申请人： Albrecht Marhold ,  Peter Wolfrum

    发明人： Albrecht Marhold ,  Peter Wolfrum

    IPC分类号： C07C25550

    CPC分类号： C07C255/57 ,  C07C17/12 ,  C07C17/14 ,  C07C25/13 ,  C07C251/48 ,  G01C21/26 ,  G01C22/002

    摘要： The present invention relates to 3-cyano-2,4,5-trifluorobenzoyl fluoride and to intermediates for its preparation and to the process for the preparation of 3-cyano-2,4,5-trifluoro-benzoyl fluoride, which starts from 5 fluoro-1,3-xylene (VIII); which is bichlorinated in the ring in the presence of a catalyst under ionic conditions to give 2,4-dichloro-5-fluoro-1,3 dimethylbenzene (VII). The latter is chlorinated in the side chains under free-radical conditions to give 2,4-dichloro-5-fluoro-3-dichloromethyl-1 trichloromethylbenzene (VI). The latter is hydrolyzed via 2,4-dichloro-5-fluoro-3-dichloromethylbenzoic acid (V), which can be isolated if necessary, to give 2,4-dichloro-5-fluoro-3-formyl-benzoic acid (IV), the aldehyde group of which is reacted to give 2,4-dichloro-5-fluoro-3-N-hydroxyiminomethyl-benzoic acid (III), from which, with simultaneous conversion of the carboxyl group into the chlorocarbonyl group, water is eliminated using an acid chloride to give the nitrile 2,4-dichloro-3-cyano-5 fluoro-benzoyl chloride (II). Finally the nitrile is subjected to fluorine/chlorine exchange.

    摘要翻译： 本发明涉及3-氰基-2,4,5-三氟苯甲酰氟及其制备中间体以及制备3-氰基-2,4,5-三氟 - 苯甲酰氟的方法，其从5 氟代-1,3-二甲苯（VIII）; 其在离子条件下在催化剂存在下在环中二氯化，得到2,4-二氯-5-氟-1,3-二甲基苯（VII）。 后者在自由基条件下在侧链中氯化，得到2,4-二氯-5-氟-3-二氯甲基-1,3-三氯甲基苯（VI）。 后者通过2,4-二氯-5-氟-3-二氯甲基苯甲酸（V）水解，如果需要可以分离，得到2,4-二氯-5-氟-3-甲酰基 - 苯甲酸（IV ），其醛基反应得到2,4-二氯-5-氟-3-N-羟基亚氨基甲基 - 苯甲酸（III），其中通过同时将羧基转化为氯羰基，水是 使用酰氯除去得到腈2,4-二氯-3-氰基-5-氟 - 苯甲酰氯（II）。 最后，腈进行氟/氯交换。