公开(公告)号：US08536389B2

公开(公告)日：2013-09-17

申请号：US13533124

申请日：2012-06-26

申请人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George William Parker

发明人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George William Parker

IPC分类号： C10L1/10 ,  C10L1/16

CPC分类号： C10L1/04 ,  C10L1/023 ,  C10L1/06

摘要： Unleaded blend composition having a Motor Octane Number (MON) of at least 80 having less than 42% of aromatic compounds, and at least 2% by volume of the total composition of component (a′), which is a substantially aliphatic hydrocarbon refinery stream of MON value of at least 85. At least 70% in total of the stream is branched chain alkanes, the stream being obtained by distillation from a refinery material as a cut having Initial Boiling Point of at least 15° C. and Final Boiling Point of at most 160° C. The Boiling Points are measured according to ASTMID2892. At least 5% of at least one paraffin, aromatic hydrocarbon compound or olefinic hydrocarbon has a bp 60-160° C., with not more than 5% of the total composition of hydrocarbon having a bp more than 160° C. Less than 5% 2,2,3-trimethylbutane or 2,2,3-trimethylpentane is present.

摘要翻译： 具有至少80摩尔辛烷值（MON）的无铅混合组合物具有少于42％的芳族化合物，和至少2体积％的组合物（a'）的总组合物，其为基本上脂族烃精炼料流 的MON值至少为85.流中至少70％为支链烷烃，该物流通过从炼油厂原料蒸馏得到，其切片具有至少15℃的初始沸点和最终沸点 至多160℃。沸点根据ASTMID2892测量。 至少一种链烷烃，芳族烃化合物或烯烃的至少5％具有bp 60-160℃，不超过总组合物的5％，其中bp大于160℃。小于5 存在％2,2,3-三甲基丁烷或2,2,3-三甲基戊烷。

公开(公告)号：US20130116487A1

公开(公告)日：2013-05-09

申请号：US13533124

申请日：2012-06-26

申请人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George Parker

发明人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George Parker

IPC分类号： C10L1/04

CPC分类号： C10L1/04 ,  C10L1/023 ,  C10L1/06

摘要： Unleaded blend composition having a Motor Octane Number (MON) of at least 80 having less than 42% of aromatic compounds, and at least 2% by volume of the total composition of component (a′), which is a substantially aliphatic hydrocarbon refinery stream of MON value of at least 85. At least 70% in total of the stream is branched chain alkanes, the stream being obtained by distillation from a refinery material as a cut having Initial Boiling Point of at least 15° C. and Final Boiling Point of at most 160° C. The Boiling Points are measured according to ASTMID2892. At least 5% of at least one paraffin, aromatic hydrocarbon compound or olefinic hydrocarbon has a bp 60-160° C., with not more than 5% of the total composition of hydrocarbon having a bp more than 160° C. Less than 5% 2,2,3-trimethylbutane or 2,2,3-trimethylpentane is present.

摘要翻译： 具有至少80摩尔辛烷值（MON）的无铅混合组合物具有少于42％的芳族化合物，和至少2体积％的组合物（a'）的总组合物，其为基本上脂族烃精炼料流 的MON值至少为85.流中至少70％为支链烷烃，该物流通过从炼油厂原料蒸馏得到，其切片具有至少15℃的初始沸点和最终沸点 至多160℃。沸点根据ASTMID2892测量。 至少一种链烷烃，芳族烃化合物或烯烃的至少5％具有bp 60-160℃，不超过总组合物的5％，其中bp大于160℃。小于5 存在％2,2,3-三甲基丁烷或2,2,3-三甲基戊烷。

公开(公告)号：US20090112912A1

公开(公告)日：2009-04-30

申请号：US11932381

申请日：2007-10-31

申请人： Richard A. Schimmel ,  Robert Paul Nieman ,  Terrence Christopher Lynch ,  Philip Howard Quinlan

发明人： Richard A. Schimmel ,  Robert Paul Nieman ,  Terrence Christopher Lynch ,  Philip Howard Quinlan

IPC分类号： G06F17/30

CPC分类号： G06F17/3089

摘要： An architecture record can be created for a computer system that includes a plurality of computing devices, each having an operating system. The architecture record includes platform definition architectures each associated with one of the computing devices and the operating system of the computing device, domain reference architectures each associated with one or more of the platform definition architectures and a service performed by the computing device of each platform definition architecture, and channel reference architectures each associated with one or more of the domain reference architectures, wherein the computing devices associated with the one or more domain reference architectures are configured to communicate with each other while performing the respective services associated with the one or more domain reference architectures.

摘要翻译： 可以为包括多个计算设备的计算机系统创建架构记录，每个计算设备具有操作系统。 架构记录包括每个与计算设备之一和计算设备的操作系统相关联的平台定义架构，每个与一个或多个平台定义架构相关联的域参考架构以及由每个平台定义的计算设备执行的服务 架构和信道参考架构，每个与一个或多个域参考架构相关联，其中与所述一个或多个域参考架构相关联的计算设备被配置为在执行与所述一个或多个域相关联的相应服务时彼此通信 参考架构。

公开(公告)号：US20080289998A1

公开(公告)日：2008-11-27

申请号：US11980821

申请日：2007-10-31

申请人： Roberto Vittorio Bazzani ,  Paul James Bennett ,  Graham Butler ,  Alisdair Quentin Clark ,  John Hardy Cooper ,  Philip Howard ,  Anthony George William Parker

发明人： Roberto Vittorio Bazzani ,  Paul James Bennett ,  Graham Butler ,  Alisdair Quentin Clark ,  John Hardy Cooper ,  Philip Howard ,  Anthony George William Parker

IPC分类号： C10G31/00

CPC分类号： C10L1/023 ,  C10L1/02 ,  C10L1/04 ,  C10L1/06

摘要： Unleaded blend compositions, as well as formulated gasolines containing them have a Motor Octane Number (MON) of at least 80 comprising either: (i) component (a) at least 5% (by volume of the total composition) of at least one hydrocarbon having the following formula I R—CH2—CH(CH3)—C(CH3)2—CH3  I wherein R is hydrogen or methyl, especially triptane, or (ii) at least 2% of component (a′), which is at least one branched chain alkane of MON value of at least 90 and of boiling point 15-160° C. or a substantially aliphatic hydrocarbon refinery stream, of MON value of at least 85, at least 70% in total of said stream being branched chain alkanes, said stream being obtainable or obtained by distillation from a refinery material as a cut having Initial Boiling Point of at least 15° C. and Final Boiling Point of at most 160° C., said Boiling Points being measured according to ASTMD2892, or (iii) at least 10% of component (a″), which is at least one branched chain alkane of 8-12 carbons with at least 4 methyl or ethyl branches The components (a), (a′) and (a″) give rise to reduced emissions to the composition or gasoline on combustion.

公开(公告)号：US20080036541A1

公开(公告)日：2008-02-14

申请号：US11501378

申请日：2006-08-08

申请人： Philip Howard Thompson

发明人： Philip Howard Thompson

IPC分类号： H03F3/68

CPC分类号： H03F3/68 ,  H03F1/30 ,  H03F3/189

摘要： To improve operation during cutback power mode by reducing gain expansion, sections of a multi-section amplifier are selectively biased. During cutback power condition, fewer than all sections of the multi-section amplifier are biased. Selective biasing reduces power consumption and obtains desired output power. To reduce gain expansion, a bias resistor is provided between one or more sections to establish a small or leakage bias current into non-enabled or non-biased sections. This leakage bias current weakly biases the non-enabled sections allowing small signal amplification by the non-enabled sections. The combined amplification of the enabled section and the weakly biased section provide greater initial gain at lower power input signal levels thereby reducing gain expansion.

摘要翻译： 为了通过减小​​增益扩展来改善在切断功率模式下的操作，多段放大器的部分被选择性地偏置。 在切断电源条件下，多段放大器的所有部分都有偏差。 选择性偏置降低功耗并获得所需的输出功率。 为了减小增益扩展，在一个或多个部分之间提供偏置电阻器，以建立一个小的或漏电偏压电流到非启用或非偏置部分。 该漏电偏置电流弱地偏置非使能部分，允许非启用部分进行小信号放大。 启用部分和弱偏置部分的组合放大在较低功率输入信号电平下提供更大的初始增益，从而减少增益扩展。

公开(公告)号：US20070191349A1

公开(公告)日：2007-08-16

申请号：US10598470

申请日：2005-03-01

申请人： Philip Howard ,  Stephen Gregson ,  Arnaud Tiberghien

发明人： Philip Howard ,  Stephen Gregson ,  Arnaud Tiberghien

IPC分类号： A61K31/551 ,  C07D487/14

CPC分类号： C07D487/04

摘要： Compounds of formula (I): PBD-A-Y—X—(Het)na-L-(Het)nb-L-(Het)nc-T-(Het′)nd-L-(Het′)ne-L-(Het′)nf—X′—Y′- A′-PBD′ and salts, solvates and chemically protected forms thereof, are disclosed wherein the PBD units have the formulae (PBD) (PBD′) with the bonds at the 8 position on each molecule bond to the A and A′ groups respectively; A is selected from O, S, NH or a single bond, and each Het and Het′ is respectively an amino-heteroarylene-carbonyl group; X and X′ are both either NH or C (═O)-Q—C(═O)— wherein Q is a divalent group such that HY═R; in a second aspectm the invention comprises compounds of the general formula (II): PBD-A-Y—X—(Het)ng-[L-(Het)nh]nj-X′—Y′-A′-PBD′. Wherein: PBD and PBD′ are as defined above, X and X′ are either NH and C(═O) respectively or C(O) and NH respectively; the other substitutents are defined in the claims. Further aspects of the present invention relate to their use in the manufacture of a medicament for the treatment of a proliferative disease.

摘要翻译： 式（I）的化合物：PBD-AYX-（Het）-Na -L-（Het）N b -L-（Het）nc < -T-（Het'） -L-（Het'） -L-（Het'）Nf -X'-Y 公开了“--A'-PBD'及其盐，溶剂合物和化学保护形式，其中PBD单元具有式（PBD）（PBD'），每个分子上的8位的键与A和A' 分别; A选自O，S，NH或单键，每个Het和Het'分别为氨基 - 亚杂芳基 - 羰基; X和X'都是NH或C（-O）-Q-C（-O） - ，其中Q是二价基团，使得HY-R; 在第二方面，本发明包括通式（II）的化合物：PBD-AYX-（Het）N - [L-（Het）nh] nj -X'-Y'-A'-PBD'。 其中：PBD和PBD'如上所定义，X和X'分别是NH和C（-O）或C（O）和NH; 其他替代物在权利要求中定义。 本发明的其它方面涉及其在制备用于治疗增殖性疾病的药物中的用途。

公开(公告)号：US20060128693A1

公开(公告)日：2006-06-15

申请号：US10534825

申请日：2003-11-14

申请人： David Thurston ,  Philip Howard

发明人： David Thurston ,  Philip Howard

IPC分类号： A61K31/551 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/551

摘要： Compounds of formula (I): formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are C disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl group; and a phenyl group substituted by: one or more chloro or fluoro groups; an ethyl or propyl group; a 4-t-butyl group; a 2-methyl group; or two methyl groups in the 2- and 6- positions.

摘要翻译： 式（I）化合物：式（I）及其盐，溶剂化物，化学保护形式及其前体是C公开的，其中R 2选自：任选取代的萘基; 任选取代的噻吩基或呋喃基; 和被一个或多个氯或氟基取代的苯基; 乙基或丙基; 4-叔丁基; 2-甲基; 或2-和6-位的两个甲基。

公开(公告)号：US07009074B2

公开(公告)日：2006-03-07

申请号：US10901643

申请日：2004-07-28

申请人： Mark Zerella ,  Sudip Mukhopadhyay ,  Alexis T. Bell ,  John Glenn Sunley ,  Sander Gaemers ,  Philip Howard ,  Brian Ellis ,  Andrew Richard Lucy

发明人： Mark Zerella ,  Sudip Mukhopadhyay ,  Alexis T. Bell ,  John Glenn Sunley ,  Sander Gaemers ,  Philip Howard ,  Brian Ellis ,  Andrew Richard Lucy

IPC分类号： C07C51/14

CPC分类号： C07C51/305 ,  C07C53/08

摘要： Acetic acid is produced by oxidation of methane with an oxygen-containing gas in the presence of an acid selected from concentrated sulfuric acid and fuming sulfuric acid, a palladium-containing catalyst and a promoter, preferably a copper or iron salt. The addition of a promoter and O2 to a system that includes a palladium-containing catalyst such as PdCl2 increases the rate of acetic acid formation from methane by more than an order of magnitude as compared with prior art and, in addition, inhibits the precipitation of Pd black.

摘要翻译： 在选自浓硫酸和发烟硫酸的酸，含钯催化剂和促进剂，优选铜或铁盐的存在下，用含氧气体氧化甲酸来生产乙酸。 将促进剂和O 2加入到包含含钯催化剂如PdCl 2 N的体系中增加了甲烷形成乙酸的速率超过一个量级 与现有技术相比，并且还抑制了Pd黑的沉淀。

公开(公告)号：US06350716B1

公开(公告)日：2002-02-26

申请号：US09665905

申请日：2000-09-20

申请人： John Cook ,  Brian Ellis ,  Philip Howard ,  Michael David Jones ,  Simon James Kitchen

发明人： John Cook ,  Brian Ellis ,  Philip Howard ,  Michael David Jones ,  Simon James Kitchen

IPC分类号： B01J2300

CPC分类号： C07C67/05 ,  B01J23/002 ,  B01J23/6525 ,  B01J23/686 ,  B01J37/0236 ,  B01J2523/00 ,  C07C51/215 ,  C07C51/25 ,  C07C67/055 ,  Y02P20/125 ,  C07C53/08 ,  C07C69/01 ,  B01J2523/18 ,  B01J2523/55 ,  B01J2523/56 ,  B01J2523/68 ,  B01J2523/827 ,  B01J2523/23 ,  B01J2523/53 ,  B01J2523/74 ,  C07C69/15

摘要： A catalyst composition for the selective oxidation of ethane and/or ethylene to acetic acid which composition comprises in combination with oxygen the elements: MOa.Wb.Agc.Ird.Xe.Yf (I) wherein X is the elements Nb and V; Y is one or more elements selected from the group consisting of: Cr, Mn, Ta, Ti, B, Al, Ga, In, Pt, Zn, Cd, Bi, Ce, Co, Rh, Cu, Au, Fe, Ru, Os, K, Rb, Cs, Mg, Ca, Sr, Ba, Zr, Hf, Ni, P, Pb, Sb, Si, Sn, Tl, U, Re and Pd; a, b, c, d, e and f represent the gram atom ratios of the elements such that 0

摘要翻译： 一种用于将乙烷和/或乙烯选择性氧化成乙酸的催化剂组合物，其组合物与氧气组合包含元素：MOa.Wb.Agc.Ird.Xe.Yf（I）其中X是元素Nb和V; Y是选自Cr，Mn，Ta，Ti，B，Al，Ga，In，Pt，Zn，Cd，Bi，Ce，Co，Rh，Cu，Au，Fe，Ru中的一种或多种元素 ，Os，K，Rb，Cs，Mg，Ca，Sr，Ba，Zr，Hf，Ni，P，Pb，Sb，Si，Sn，Tl，U，Re和Pd; a，b，c，d，e和f表示元素的克原子比，使得0

公开(公告)号：US4520118A

公开(公告)日：1985-05-28

申请号：US580673

申请日：1984-02-16

申请人： Brian R. Gane ,  Philip Howard

发明人： Brian R. Gane ,  Philip Howard

IPC分类号： C07C2/76 ,  B01J29/06 ,  B01J29/90 ,  C07B61/00 ,  C07C1/00 ,  C07C2/00 ,  C07C15/00 ,  C07C15/02 ,  C07C67/00 ,  B01J25/04

CPC分类号： B01J29/90 ,  B01J29/061 ,  C07C2/00 ,  C07C2523/08 ,  C07C2529/06 ,  Y02P20/584

摘要： This invention relates to a method of improving the catalytic activity of a freshly made zeolite loaded with gallium ions by first treating with steam and then with hydrogen. Steam and hydrogen treatment may be carried out before or after loading with gallium simultaneously or successively. It has been found that a combination of steam and hydrogen treatments gives high conversions of hydrocarbon feeds and high selectivity to aromatics.

摘要翻译： 本发明涉及通过首先用蒸汽处理然后用氢处理来提高装载有镓离子的新制沸石的催化活性的方法。 蒸汽和氢气处理可以在镓同时或相继加载之前或之后进行。 已经发现，蒸汽和氢气处理的组合给出了烃进料的高转化率和对芳族化合物的高选择性。