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公开(公告)号：US20100166694A1
公开(公告)日：2010-07-01
申请号：US12450377
申请日：2008-03-31
IPC分类号： A61K31/79 , C07K16/24 , A61K31/65 , A61K31/43 , A61K31/7048 , A61K38/12 , A61K31/655 , A61K33/38 , A61P17/02 , G01N33/68 , C12Q1/02 , G01N33/53 , G01N30/00
CPC分类号： G01N33/6863 , C12Q1/04 , G01N33/54366 , G01N33/569 , G01N2800/042
摘要： The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.
摘要翻译： 本发明涉及测定受试者中伤口（特别是糖尿病性溃疡）中的微生物生物负载的方法，所述方法包括测量伤口样品中细胞因子水平的步骤，其中细胞因子水平低于 参考水平表明伤口中显着的微生物生物负载（或高于参考水平的细胞因子水平表示伤口中微生物生物负载不明显）。 本发明提供了伤口感染的诊断，预后和治疗方法，以及用于这些方法的装置和试剂盒。
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公开(公告)号：US20110110900A1
公开(公告)日：2011-05-12
申请号：US12997363
申请日：2009-06-11
CPC分类号： A61K35/12 , C12N5/0632
摘要： The invention relates to the isolation and use of a novel progenitor cell population from the lamina propria of the oral mucosa. The novel progenitor cell population is highly proliferative and can be differentiated into a range of cell lineages. Further, these novel progenitor cells possess immunomodulatory activity and so can be used in the allogeneic transfer of tissue or to help combat immune disorders.
摘要翻译： 本发明涉及分离和使用来自口腔粘膜固有层的新型祖细胞群。 新型祖细胞群高度增殖，可分化成一系列细胞系。 此外，这些新型祖细胞具有免疫调节活性，因此可用于组织的同种异体转移或帮助对抗免疫疾病。
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3.发明授权公开(公告)号：US06362817B1
公开(公告)日：2002-03-26
申请号：US09080890
申请日：1998-05-18
申请人： Michael Powers , Philip Stephens
发明人： Michael Powers , Philip Stephens
IPC分类号： G06T1500
CPC分类号： G06T17/00
摘要： A computer-based system for designing and using three-dimensional environments over a bandwidth limited network such as the Internet. The system allows an environment to be specified as a series of two-dimensional grids of text characters. Each character occupies a single grid position and represents an object in the environment. Objects can be given characteristics such as texture maps, and associated images and sounds that are triggered by events such as a user approaching the object. An object or image can be a hyperlink so that, when clicked or moved upon, the user is transported to a new location. A basic set of objects and media (images and sounds) is provided so that a designer of an environment does not have to perform low-level three-dimensional modeling. Objects can behave differently when placed near one another. For example, walls fuse together to provide a longer wall. Ramps weld together to provide a single, longer, ramp having a slope that is shallower than the two or more ramps welded together. The environments are customizable by referring to block objects, texture maps, bitmap images, sound files, etc., that can be located anywhere on the Internet, including the user's computer. The system adapts to display differing levels of detail dependent on the performance ability of the user's computer platform.
摘要翻译： 一种基于计算机的系统，用于在诸如因特网的带宽有限的网络上设计和使用三维环境。 该系统允许将环境指定为一系列文本字符的二维网格。 每个角色占用单个网格位置，并表示环境中的一个对象。 对象可以被赋予特征，例如纹理映射，以及由诸如接近对象的用户触发的相关联的图像和声音。 对象或图像可以是超链接，使得当被点击或移动时，用户被传送到新的位置。 提供了一组基本的对象和媒体（图像和声音），使得环境的设计者不必执行低级的三维建模。 当彼此靠近放置时，对象的行为可能会有所不同。 例如，墙壁熔合在一起以提供更长的墙壁。 斜坡焊接在一起以提供具有比两个或多个焊接在一起的坡道浅的斜坡的单个更长的坡道。 可以通过参考可以位于互联网上任何地方（包括用户的计算机）的块对象，纹理映射，位图图像，声音文件等来定制环境。 该系统适应于显示不同级别的细节，取决于用户的计算机平台的性能。
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公开(公告)号：US08491852B2
公开(公告)日：2013-07-23
申请号：US11914884
申请日：2006-04-24
IPC分类号： G01N33/52
CPC分类号： G01N33/528 , C12Q1/26 , G01N33/523 , G01N33/6893
摘要： An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.
摘要翻译： 当哺乳动物伤口流体的样品的抗氧化能力超过感染伤口特征的预定最小水平时，指示装置适于产生可检测信号。 还提供了用于诊断和治疗伤口的系统，包括本发明的诊断装置和包含至少一种用于选择性应用于感染伤口的抗微生物剂的伤口敷料。 还提供了通过本发明的装置和系统进行诊断和治疗的方法。
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公开(公告)号：US20090299161A1
公开(公告)日：2009-12-03
申请号：US11914884
申请日：2006-04-24
IPC分类号： A61B5/1468 , A61F13/00 , A61M35/00
CPC分类号： G01N33/528 , C12Q1/26 , G01N33/523 , G01N33/6893
摘要： An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.
摘要翻译： 当哺乳动物伤口流体的样品的抗氧化能力超过感染伤口特征的预定最小水平时，指示装置适于产生可检测信号。 还提供了用于诊断和治疗伤口的系统，包括本发明的诊断装置和包含至少一种用于选择性应用于感染伤口的抗微生物剂的伤口敷料。 还提供了通过本发明的装置和系统进行诊断和治疗的方法。
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公开(公告)号：US20120010099A1
公开(公告)日：2012-01-12
申请号：US13224647
申请日：2011-09-02
CPC分类号： G01N33/6863 , C12Q1/04 , G01N33/54366 , G01N33/569 , G01N2800/042
摘要： The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.
摘要翻译： 本发明涉及测定受试者中伤口（特别是糖尿病性溃疡）中的微生物生物负载的方法，所述方法包括测量伤口样品中细胞因子水平的步骤，其中细胞因子水平低于 参考水平表明伤口中显着的微生物生物负载（或高于参考水平的细胞因子水平表示伤口中微生物生物负载不明显）。 本发明提供了伤口感染的诊断，预后和治疗方法，以及用于这些方法的装置和试剂盒。
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公开(公告)号：US08012698B2
公开(公告)日：2011-09-06
申请号：US12450377
申请日：2008-03-31
IPC分类号： G01N33/53
CPC分类号： G01N33/6863 , C12Q1/04 , G01N33/54366 , G01N33/569 , G01N2800/042
摘要： The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.
摘要翻译： 本发明涉及测定受试者中伤口（特别是糖尿病性溃疡）中的微生物生物负载的方法，所述方法包括测量伤口样品中细胞因子水平的步骤，其中细胞因子水平低于 参考水平表明伤口中显着的微生物生物负载（或高于参考水平的细胞因子水平表示伤口中微生物生物负载不明显）。 本发明提供了伤口感染的诊断，预后和治疗方法，以及用于这些方法的装置和试剂盒。
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