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公开(公告)号:US06610701B2
公开(公告)日:2003-08-26
申请号:US10071422
申请日:2002-02-08
申请人: James C. Barrow , Craig Coburn , Harold G. Selnick , Phung L. Ngo
发明人: James C. Barrow , Craig Coburn , Harold G. Selnick , Phung L. Ngo
IPC分类号: A61K314375
CPC分类号: C07D213/75 , C07D213/26 , C07D213/89 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D471/04
摘要: Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: wherein R3 is hydrogen or halogen, and u is N or CH.
摘要翻译: 本发明化合物可用于抑制凝血酶和治疗凝血和心血管疾病,并具有以下结构:其中R 3为氢或卤素,u为N或CH。
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公开(公告)号:US06534510B2
公开(公告)日:2003-03-18
申请号:US09815404
申请日:2001-03-22
IPC分类号: C07D40100
CPC分类号: C07D401/12 , C07D401/14 , C07D471/04
摘要: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group consisting of: or a pharmaceutically acceptable salt thereof, wherein A is
摘要翻译: 本发明的化合物可用于抑制凝血酶和相关的血栓闭塞,并且选自:或其药学上可接受的盐,其中A是
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