公开(公告)号：US07504511B2

公开(公告)日：2009-03-17

申请号：US11253998

申请日：2005-10-19

Applicant: Pierre Carayon ,  Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham ,  Bernard Labeeuw

Inventor： Pierre Carayon ,  Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham ,  Bernard Labeeuw

IPC: C07D211/68 ,  C07D277/00 ,  A61K31/425

CPC classification number: C07D401/04 ,  C07D277/46 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D487/08

Abstract: The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.

Abstract translation: 本发明涉及通式（I）的2-酰基氨基-4-苯基噻唑衍生物：其药学上可接受的酸加成盐，该衍生物的水合物或溶剂合物或其药学上可接受的酸加成盐，其中间体，其制备方法， 及其治疗应用。

公开(公告)号：US06779574B2

公开(公告)日：2004-08-24

申请号：US09995340

申请日：2001-11-27

Applicant: Robert Vanstory Teeple ,  James Endicott ,  Jean-Luc Bouvier ,  Pierre Fraisse ,  Jean-Claude Faure

Inventor： Robert Vanstory Teeple ,  James Endicott ,  Jean-Luc Bouvier ,  Pierre Fraisse ,  Jean-Claude Faure

IPC: B60C1500

CPC classification number: B60C15/0081 ,  B60C15/0018 ,  B60C15/0027 ,  B60C15/0045 ,  B60C15/024 ,  B60C15/0247 ,  B60C15/06 ,  B60C2015/048 ,  Y10T152/10819 ,  Y10T152/10846

Abstract: A tire with radial carcass reinforcement having beads with a heel portion on an axially inner side and a toe portion on an axially outer side includes two carcass reinforcement plies for tension in higher sidewall tires. The bead includes at least one bead wire coated with a rubber mix, a wedge formed of a rubber mix disposed axially outward of the at least one bead wire, and at least one rubber filler located axially and radially outward of the bead wire and wedge. The wedge is defined by two sides extending at an acute angle axially from an apex A located beneath the section of the at least one bead wire, the rubber mix forming the wedge having a Shore A hardness of at least 65 and greater than the Shore A hardness of the at least one rubber filler. According to one embodiment, a carcass reinforcement includes two plies, a first radial reinforcement ply wound on the at least one bead wire to form a first upturn, as viewed in meridian section, the reinforcement ply is wound about said bead wire passing from the heel to the toe of said at least one bead, the first upturn engaging the radially outer side the wedge and, a second radial reinforcement ply wound on said at least one bead wire, wherein, when viewed in meridian section, the second reinforcement ply is disposed in parallel to the first radial reinforcement ply in a sidewall area of the tire and is wound about said bead wire passing from the heel to the toe of said at least one bead with a second upturn extending into engagement with the radial inner side of the wedge.

Abstract translation: 具有径向胎体加强件的轮胎具有在轴向内侧上具有跟部部分和在轴向外侧上的脚趾部分的胎圈，包括用于在较高侧壁轮胎中张紧的两个胎体增强帘布层。 胎圈包括涂覆有橡胶混合物的至少一个胎圈丝线，由至少一个胎圈丝线的轴向外侧布置的橡胶混合物形成的楔形物，以及位于胎圈丝和楔形物的轴向和径向外侧的至少一个橡胶填料。 楔形物由两个侧面限定，两个侧面从位于至少一个胎圈丝的截面下方的顶点A的轴向轴向延伸，形成楔形件的橡胶混合物的肖氏A硬度至少为65°并且大于肖氏A 至少一种橡胶填料的硬度。 根据一个实施例，胎体增强件包括两个帘布层，第一径向加强层卷绕在至少一个胎圈丝上以形成第一上翻，如在子午线部分中所看到的，加强层卷绕在从脚跟 所述至少一个胎圈的脚趾，所述第一上翘接合所述径向外侧的所述楔和所述至少一个胎圈丝的第二径向增强层，其中，当在子午线部分中观察时，设置所述第二加强层 平行于轮胎的侧壁区域中的第一径向增强层，并且缠绕在所述胎圈丝线周围，所述胎圈丝线从所述鞋跟延伸到所述至少一个胎圈的脚趾，具有延伸成与所述楔形件的径向内侧接合的第二向上 。

公开(公告)号：US07825112B2

公开(公告)日：2010-11-02

申请号：US12146898

申请日：2008-06-26

Applicant: Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Stephane Hourcade ,  Samir Jegham

Inventor： Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Stephane Hourcade ,  Samir Jegham

IPC: A61K31/551 ,  A61K31/496 ,  A61K31/427 ,  C07D277/44 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D277/46 ,  C07D417/12 ,  C07D417/14

Abstract: The disclosure relates to 2-carbamide-4-phenylthiazole derivatives having the following general formula (I): wherein R1, R2, R3, Y and p are as defined in the disclosure. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).

Abstract translation: 本公开涉及具有以下通式（I）的2-氨基-4-苯基噻唑衍生物：其中R1，R2，R3，Y和p如本公开所定义。 本公开还涉及含有式（I）化合物的药物组合物，其用于制备式（I）化合物的方法，以及使用式（I）化合物的方法。

公开(公告)号：US20100222319A1

公开(公告)日：2010-09-02

申请号：US12732749

申请日：2010-03-26

Applicant: Claude BERNHART ,  Monsif BOUABOULA ,  Pierre CASELLAS ,  Samir JEGHAM ,  Jèrome ARIGON ,  Romain COMBET ,  Sandrine HILAIRET ,  Pierre FRAISSE

Inventor： Claude BERNHART ,  Monsif BOUABOULA ,  Pierre CASELLAS ,  Samir JEGHAM ,  Jèrome ARIGON ,  Romain COMBET ,  Sandrine HILAIRET ,  Pierre FRAISSE

IPC: A61K31/4545 ,  A61P35/00 ,  C07F5/02 ,  C07D401/12 ,  A61K31/444 ,  C07D401/14 ,  A61K31/496 ,  C07D417/14 ,  A61K31/541 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/55

CPC classification number: C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14

Abstract: The disclosure relates to compounds of formula (I): wherein A, Z, Z′, L, R2 and R3 are as defined in the disclosure, to compositions comprising said compounds, and to methods for the manufacture and therapeutic use thereof.

Abstract translation: 本公开涉及式（I）化合物：其中A，Z，Z'，L，R 2和R 3如本公开所定义，包含所述化合物的组合物，以及其制备和治疗用途的方法。

公开(公告)号：US07777041B2

公开(公告)日：2010-08-17

申请号：US12360568

申请日：2009-01-27

Applicant: Pierre Carayon ,  Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham ,  Bernard Labeeuw

Inventor： Pierre Carayon ,  Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham ,  Bernard Labeeuw

IPC: C07D405/00

CPC classification number: C07D401/04 ,  C07D277/46 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D487/08

Abstract: The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.

Abstract translation: 本发明涉及通式（I）的2-酰基氨基-4-苯基噻唑衍生物：其药学上可接受的酸加成盐，该衍生物的水合物或溶剂合物或其药学上可接受的酸加成盐，其中间体，其制备方法， 及其治疗应用。

公开(公告)号：US07598392B2

公开(公告)日：2009-10-06

申请号：US11736770

申请日：2007-04-18

Applicant: Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

Inventor： Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

IPC: A61K31/427 ,  A61K31/497 ,  A61K31/506 ,  A61K31/4545 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D417/14

Abstract: The disclosure relates to 2-amido-4-phenylthiazole derivatives of general formula (I) below: in which R1, R2, R3, Y, m, n, and p are as defined in the disclosure; as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic use thereof.

Abstract translation: 本公开涉及以下通式（I）的2-氨基-4-苯基噻唑衍生物：其中R 1，R 2，R 3，Y，m，n和p如本公开所定义; 以及它们的异构体，盐和溶剂合物，含有它们的药物组合物及其治疗用途。

公开(公告)号：US20090018117A1

公开(公告)日：2009-01-15

申请号：US12146898

申请日：2008-06-26

Applicant: Pierre CASELLAS ,  Daniel FLOUTARD ,  Pierre FRAISSE ,  Stephane HOURCADE ,  Samir JEGHAM

Inventor： Pierre CASELLAS ,  Daniel FLOUTARD ,  Pierre FRAISSE ,  Stephane HOURCADE ,  Samir JEGHAM

IPC: A61K31/551 ,  C07D417/12 ,  C07D417/14 ,  A61K31/496

CPC classification number: C07D277/46 ,  C07D417/12 ,  C07D417/14

Abstract: The disclosure relates to 2-carbamide-4-phenylthiazole derivatives having the following general formula (I): wherein R1, R2, R3, Y and p are as defined in the disclosure. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).

Abstract translation: 本公开涉及具有以下通式（I）的2-氨基-4-苯基噻唑衍生物：其中R1，R2，R3，Y和p如本公开所定义。 本公开还涉及含有式（I）化合物的药物组合物，其用于制备式（I）化合物的方法，以及使用式（I）化合物的方法。

公开(公告)号：US20070179126A1

公开(公告)日：2007-08-02

申请号：US11649316

申请日：2007-01-03

Applicant: Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

Inventor： Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

IPC: A61K31/5377 ,  A61K31/496 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D277/40 ,  C07D277/46

Abstract: The disclosure concerns 2-carbamide-4-phenylthiazole derivatives of general formula (I). The disclosure also concerns pharmaceutical compositions containing a compound of general formula (I) and to processes for preparing and methods of using compounds of general formula (I).

Abstract translation: 本公开涉及通式（I）的2-氨基-4-苯基噻唑衍生物。 本公开还涉及含有通式（I）化合物的药物组合物及其制备方法和使用通式（I）的化合物的方法。

公开(公告)号：US20060135575A1

公开(公告)日：2006-06-22

申请号：US11253998

申请日：2005-10-19

Applicant: Pierre Carayon ,  Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham ,  Bernard Labeeuw

Inventor： Pierre Carayon ,  Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham ,  Bernard Labeeuw

IPC: C07D277/18 ,  A61K31/426

CPC classification number: C07D401/04 ,  C07D277/46 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D487/08

Abstract: The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.

Abstract translation: 本发明涉及通式（I）的2-酰基氨基-4-苯基噻唑衍生物：其药学上可接受的酸加成盐，该衍生物的水合物或溶剂合物或其药学上可接受的酸加成盐，其中间体，其制备方法， 及其治疗应用。

公开(公告)号：US07767681B2

公开(公告)日：2010-08-03

申请号：US11649316

申请日：2007-01-03

Applicant: Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

Inventor： Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

IPC: A61K31/497 ,  C07D413/14

CPC classification number: C07D417/12 ,  C07D277/40 ,  C07D277/46

Abstract: The disclosure concerns 2-carbamide-4-phenylthiazole derivatives of general formula (I). The disclosure also concerns pharmaceutical compositions containing a compound of general formula (I) and to processes for preparing and methods of using compounds of general formula (I).

Abstract translation: 本公开涉及通式（I）的2-氨基-4-苯基噻唑衍生物。 本公开还涉及含有通式（I）化合物的药物组合物及其制备方法和使用通式（I）的化合物的方法。