公开(公告)号：US4505921A

公开(公告)日：1985-03-19

申请号：US529735

申请日：1983-09-06

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger

IPC: A61K31/64 ,  A61P3/08 ,  A61P3/10 ,  C07D209/46 ,  C07D209/48 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D491/048 ,  A61K31/395 ,  C07D519/00

CPC classification number: C07D209/48 ,  C07D209/46 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  Y10S514/866

Abstract: New sulfonylurea compounds of the formula: ##STR1## in which n is 1 or 2,R is thienyl, furyl, pyridyl or phenyl optionally mono or disubstituted,R.sub.1 and R.sub.2, the same or different, each are hydrogen, halogen, (C.sub.1 to C.sub.5)-alkyl, (C.sub.1 to C.sub.5)-alkoxy, or trifluoromethyl, or together represent --CH.sub.2 --O--CH.sub.2 --,R.sub.3 is hydrogen, or hydroxy, andR.sub.4 is (C.sub.1 to C.sub.5)-alkyl, (C.sub.3 to C.sub.8)-cycloalkyl or azacycloalkyl of the formula: ##STR2## in which p is zero or an integer from 1 to 5, or azabicycloalkyl of the formula: ##STR3## in which m is 1, 2, or 3. These new compounds and physiologically tolerable salts thereof may be used as medicines especially in the treatment of diabetes.

Abstract translation: 新的具有下式的磺酰脲化合物：其中n为1或2，R为噻吩基，呋喃基，吡啶基或苯基，任选单取代或二取代，R 1和R 2相同或不同，各自为氢，卤素，（C 1至 C 1 -C 5） - 烷基，（C 1 -C 5） - 烷氧基或三氟甲基，或一起表示-CH 2 -O-CH 2 - ，R 3为氢或羟基，且R 4为（C 1至C 5） - 烷基，（C 3至C 8） 环烷基或氮杂环烷基，其中p为0或1至5的整数，或下式的氮杂双环烷基：其中m为1,2或3.这些新化合物和生理上可耐受的 其盐可以用作药物，特别是用于治疗糖尿病。

公开(公告)号：US4066662A

公开(公告)日：1978-01-03

申请号：US755476

申请日：1976-12-30

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Xavier Pascaud ,  Jean-Claude Poignant

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Xavier Pascaud ,  Jean-Claude Poignant

IPC: C07D209/44 ,  C07D209/52 ,  A61K31/40

CPC classification number: C07D209/52 ,  C07D209/44 ,  Y10S514/926

Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

公开(公告)号：US4042598A

公开(公告)日：1977-08-16

申请号：US685757

申请日：1976-05-13

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Xavier Pascaud ,  Jean-Claude Poignant

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Xavier Pascaud ,  Jean-Claude Poignant

IPC: C07D209/44 ,  C07D209/52

CPC classification number: C07D209/44 ,  C07D209/52

Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

公开(公告)号：US5266718A

公开(公告)日：1993-11-30

申请号：US898916

申请日：1992-06-12

Applicant: Michel Wierzbicki ,  Pierre Hugon ,  Jacques Duhault ,  Francoise Lacour ,  Michelle Boulanger

Inventor： Michel Wierzbicki ,  Pierre Hugon ,  Jacques Duhault ,  Francoise Lacour ,  Michelle Boulanger

IPC: C07C219/14 ,  C07C233/51 ,  C07C235/34 ,  C07C101/34

CPC classification number: C07C219/14 ,  C07C233/51 ,  C07C235/34 ,  C07C2103/18

Abstract: New ethanolamine benzoate compounds which can be used as medicaments and correspond to the formula: ##STR1## wherein R is as defined in the description, in the form of racemic compounds and enantiomers. These new compounds and their physiologically tolerable salts can be used therapeutically for treatment of insulin-resistance states.

Abstract translation: 新的可用作药物的乙醇胺苯甲酸酯化合物，其对应于下式：其中R如说明书中所定义，以外消旋化合物和对映体的形式。 这些新化合物及其生理上可耐受的盐可用于治疗胰岛素抵抗状态。

公开(公告)号：US4161529A

公开(公告)日：1979-07-17

申请号：US877601

申请日：1978-02-14

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger

IPC: C07D207/08 ,  A61K31/40 ,  A61P3/06 ,  A61P3/08 ,  C07D207/09 ,  C07D207/06

CPC classification number: C07D207/09

Abstract: Pyrrolidone derivatives of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl,AndY is hydrogen, saturated or unsaturated hydrocarbon radical up to C.sub.4, hydroxyethyl, hydroxypropyl or carboxymethyl.These compounds are used as medicines especially in the treatment of lipid-metabolism disorders.

Abstract translation: 吡咯烷酮衍生物，其结构式如下：其中R为氢，卤素，低级烷基，低级烷氧基或三氟甲基，Y为氢，饱和或不饱和烃基直至C 4，羟乙基，羟丙基或羧甲基。

公开(公告)号：US4048321A

公开(公告)日：1977-09-13

申请号：US685756

申请日：1976-05-13

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Xavier Pascaud ,  Jean-Claude Poignant

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Xavier Pascaud ,  Jean-Claude Poignant

IPC: C07D209/44 ,  C07D209/52 ,  A61K31/40 ,  C07D207/12

CPC classification number: C07D209/52 ,  C07D209/44 ,  Y10S514/872

Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

Abstract translation: 下式的二取代氮杂双环烷烃其中：

公开(公告)号：US4032658A

公开(公告)日：1977-06-28

申请号：US570876

申请日：1975-04-23

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger

IPC: C07D295/08 ,  A61K31/215 ,  A61K31/22 ,  A61P1/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/14 ,  C07C227/16 ,  C07C227/18 ,  C07C229/14 ,  C07C229/36 ,  C07D209/52 ,  C07D295/088 ,  C07C101/04

CPC classification number: C07D295/088 ,  C07D209/52

Abstract: Alkanolamine derivatives and their optical isomers of the formula: ##STR1## wherein: N IS 2 OR 3, ANDR.sub.1 and R.sub.2 are lower alkyl or taken together with the nitrogen to which they are bonded, they form pyrrolidinyl, piperidino, dimethyl piperidino, morpholino, 1-thiomorpholino, azabicyclo [3, 3, 0] octyl or azabicyclo [3, 2, 2] nonyl.These compounds are used as medicines especially in the treatment of obesity, atheroma or metabolic diseases requiring weight reduction and regulation.

公开(公告)号：US5266591A

公开(公告)日：1993-11-30

申请号：US979202

申请日：1992-11-20

Applicant: Michel Wierzbicki ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger ,  Francoise Lacour

Inventor： Michel Wierzbicki ,  Pierre Hugon ,  Jacques Duhault ,  Michelle Boulanger ,  Francoise Lacour

IPC: A61K31/24 ,  A61P3/06 ,  A61P3/08 ,  A61P7/00 ,  A61P9/12 ,  C07C233/51 ,  C07C235/34

CPC classification number: C07C233/51 ,  C07C2103/18

Abstract: The compounds are ethanolamine benzoate compounds useful for the treatment of syndrome X, and of hypertension in patients who are insulin resistant or have one or more metabolic anomalies.A compound disclosed is S-1-(m-trifluoromethylphenyl)-2-{.beta.-{4-[2-(N-(3,3-diphenylpropionyl)amino)ethyl] benzoyloxy}ethylamino} propane.

Abstract translation: 这些化合物是可用于治疗综合征X的乙醇胺苯甲酸酯化合物，以及患有胰岛素抵抗或具有一种或多种代谢异常的患者的高血压。 所公开的化合物是S-1-（间三氟甲基苯基）-2- {β-（4- [2-（N-（3,3-二苯基丙酰基）氨基）乙基]苯甲酰氧基}乙基氨基}丙烷。

公开(公告)号：US5079245A

公开(公告)日：1992-01-07

申请号：US375591

申请日：1989-07-05

Applicant: Michel Wierzbicki ,  Pierre Hugon ,  Jacques Duhault ,  Francoise Lacour

Inventor： Michel Wierzbicki ,  Pierre Hugon ,  Jacques Duhault ,  Francoise Lacour

IPC: A61K31/045 ,  A61K31/12 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  C07C29/38 ,  C07C35/23 ,  C07C45/00 ,  C07C49/697 ,  C07C67/00 ,  C07C209/00 ,  C07C209/40 ,  C07C209/48 ,  C07C209/50 ,  C07C209/52 ,  C07C209/62 ,  C07C211/30 ,  C07C211/42 ,  C07C211/52 ,  C07C215/08 ,  C07C215/42 ,  C07C215/44 ,  C07C219/14 ,  C07C223/02 ,  C07C229/14 ,  C07C231/06 ,  C07C231/10 ,  C07C233/13 ,  C07C233/14 ,  C07C233/36 ,  C07C233/66 ,  C07C241/00 ,  C07C251/04 ,  C07C251/18 ,  C07C251/20 ,  C07C251/24 ,  C07D211/18 ,  C07D233/04 ,  C07D295/06 ,  C07D295/073 ,  C07D521/00

CPC classification number: C07D295/073 ,  C07C211/30 ,  C07C211/42 ,  C07C215/08 ,  C07C215/44 ,  C07C219/14 ,  C07C229/14 ,  C07C233/14 ,  C07C233/36 ,  C07C251/18 ,  C07D233/04 ,  C07C2102/12

Abstract: The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.

Abstract translation: 公开和公开了化合物2-三氟甲基-7-取代-6,7,8,9-四氢 - [5H] - 苯并环庚烯，可用于治疗代谢疾病如糖尿病，肥胖及其并发症。 延迟化合物是2-三氟甲基-7-氨基-6,7,8,9-四氢 - [5H-苯并环庚烷。

公开(公告)号：US4259335A

公开(公告)日：1981-03-31

申请号：US64091

申请日：1979-08-06

Applicant: Laszlo Beregi ,  Pierre Hugon ,  Jacques Bure ,  Francoise Degrand

Inventor： Laszlo Beregi ,  Pierre Hugon ,  Jacques Bure ,  Francoise Degrand

IPC: A61K31/47 ,  A61P25/04 ,  A61P29/00 ,  C07D401/12

CPC classification number: C07D401/12

Abstract: 1-methyl-4-piperidinol esters of the formula: ##STR1## in which R is 7-chloro-4-quinolyl, 7-trifluoromethyl-4-quinolyl or 8-trifluoromethyl-4-quinolyl.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of inflammatory processes and painful syndroms.

Abstract translation: 1-甲基-4-哌啶醇，其具有下式：其中R是7-氯-4-喹啉基，7-三氟甲基-4-喹啉基或8-三氟甲基-4-喹啉基。 这些化合物和其生理上可耐受的酸加成盐可以用作药物，特别是用于治疗炎症过程和疼痛综合征。