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    6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acid, antibacterial compositions thereof and method of use thereof
    1.
    发明授权
    6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acid, antibacterial compositions thereof and method of use thereof 失效
    6-氨基螺[penam-2,4'-哌啶] -3-羧酸，其抗菌组合物及其使用方法

    公开(公告)号：US4271173A

    公开(公告)日：1981-06-02

    申请号：US162615

    申请日：1980-06-24

    申请人： Ludovic Rodriguez ,  Jacques Leclercq ,  Pierre Ykman ,  Eric Cossement

    发明人： Ludovic Rodriguez ,  Jacques Leclercq ,  Pierre Ykman ,  Eric Cossement

    IPC分类号： C07D499/46 ,  A61K31/43 ,  A61K31/431 ,  A61P31/04 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  C07D499/74 ,  C07D499/76 ,  C07D499/80 ,  C07D499/90 ,  C07D499/32 ,  A61K31/425

    CPC分类号： C07D499/00

    摘要： 6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acid derivatives having the formula ##STR1## wherein R is a methyl, phenyl or benzyl radical, Z.sub.1 is a hydrogen atom and Z.sub.2 is a radical selected from those known from penicillin chemistry and is preferably a 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl radical, or Z.sub.1 and Z.sub.2 together represent a bivalent radical Z.sub.3 and preferably a (hexahydro-1H-azepin-1-yl)methylene radical, as well as the pharmaceutically acceptable non-toxic salts thereof and process for preparing the same.These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

    摘要翻译： 6-氨基螺[penam-2,4'-哌啶] -3-羧酸衍生物，其结构式为：其中R为甲基，苯基或苄基，Z1为氢原子，Z2为选自 由青霉素化学已知的那些，优选2-苯基乙酰基，2-氨基-2-苯基乙酰基，5-甲基-3-苯基-4-异恶唑羰基或2,6-二甲氧基苯甲酰基，或Z 1和Z 2一起代表二价基团Z 3 并且优选为（六氢-1H-吖庚因-1-基）亚甲基，以及其药学上可接受的无毒盐及其制备方法。 这些化合物具有有价值的抗菌性质，可用作治疗由革兰氏阳性菌和革兰氏阴性菌引起的传染病的治疗剂。

    Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives
    2.
    发明授权
    Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives 失效
    氨基螺（8）氧杂（或硫杂）环烷烃 - penam {9-羧酸衍生物

    公开(公告)号：US4139628A

    公开(公告)日：1979-02-13

    申请号：US869860

    申请日：1978-01-16

    申请人： Ludovic Rodriguez ,  Jacques Leclercq ,  Pierre Ykman ,  Eric Cossement

    发明人： Ludovic Rodriguez ,  Jacques Leclercq ,  Pierre Ykman ,  Eric Cossement

    IPC分类号： C07D513/20 ,  A61K31/43 ,  A61K31/431 ,  A61P31/04 ,  C07D499/00 ,  C07D499/21 ,  C07D499/44 ,  C07D499/90

    CPC分类号： C07D499/00

    摘要： Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives having the formula ##STR1## WHEREIN X is a sulfur or oxygen atom or the sulfinyl group, n is 1 or 2, m is 1 or 2, R.sub.1 is hydrogen, R.sub.2 is one of the radicals known in the chemistry of the penicillins, preferably 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl, or R.sub.1 and R.sub.2 together represent a bivalent radical R.sub.3, preferably (hexahydro-1H-azepin-1-yl)methylene and their therapeutically acceptable non-toxic salts and process for preparing the same.These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

    摘要翻译： 具有式“IMAGE”的X'（或硫杂）环烷烃 - penam] - 羧酸衍生物，X为硫或氧原子或亚磺酰基，n为1或2，m为1或2，R 1为 氢，R2是青霉素化学中已知的基团之一，优选2-苯乙酰基，2-氨基-2-苯乙酰基，5-甲基-3-苯基-4-异恶唑羰基或2,6-二甲氧基苯甲酰基，或R1和 R2一起代表二价基团R 3，优选（六氢-1H-吖庚因-1-基）亚甲基及其治疗上可接受的无毒盐及其制备方法。