公开(公告)号：US08853149B2

公开(公告)日：2014-10-07

申请号：US13636010

申请日：2011-03-21

申请人： Lori Hazlehurst ,  Mark McLaughlin ,  Priyesh Jain ,  William S. Dalton

发明人： Lori Hazlehurst ,  Mark McLaughlin ,  Priyesh Jain ,  William S. Dalton

IPC分类号： A61K38/00 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  A61K45/06

摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

摘要翻译： 使用β-转角启动子的整联蛋白相互作用抑制剂在本文中描述。 通过施用治疗有效量的整联蛋白相互作用抑制剂，这些肽可用于治疗癌症如多发性骨髓瘤。 数据显示整联蛋白相互作用抑制剂与抗增殖剂如多柔比星，SAHA，三氧化二砷和依托泊苷协同或加成相互作用。

公开(公告)号：US20130065837A1

公开(公告)日：2013-03-14

申请号：US13636010

申请日：2011-03-21

申请人： Lori Hazlehurst ,  Mark Mclaughlin ,  Priyesh Jain ,  William S. Dalton

发明人： Lori Hazlehurst ,  Mark Mclaughlin ,  Priyesh Jain ,  William S. Dalton

IPC分类号： A61K38/12 ,  C12N5/09 ,  C07K7/54 ,  A61P35/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  A61K45/06

摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.