公开(公告)号：US20240335660A1

公开(公告)日：2024-10-10

申请号：US18747333

申请日：2024-06-18

申请人： Pulse Biosciences, Inc.

发明人： Cameron D. HINMAN ,  Wesley C. JOE

IPC分类号： A61N1/36 ,  A61N1/04

CPC分类号： A61N1/36034 ,  A61N1/0496

摘要： Applicators, systems, and methods for delivering electrical energy to a target treatment region with large area surface electrodes are disclosed. In one example, a system may include a housing, a pulse generator, and a treatment applicator coupled to the pulse generator and configured to deliver sub-microsecond high-voltage electric pulses from the pulse generator. The treatment applicator may include a first and second electrodes coupled to a substrate, where the first and second electrodes are configured to provide a uniform gap between edges of the first and second electrodes.

公开(公告)号：US20240164833A1

公开(公告)日：2024-05-23

申请号：US18423280

申请日：2024-01-25

申请人： Pulse Biosciences, Inc.

发明人： Roman TUROVSKIY ,  David R. KIRKLAND ,  David J. DANITZ ,  David MOOSAVI ,  Rodel QUINTOS ,  Ryan C. BRADWAY ,  Andy E. DENISON ,  Dylan R. MONTGOMERY ,  Peter J. D'AQUANNI

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00577

摘要： Methods and apparatuses are disclosed for providing pulsed electrical treatment (including high voltage, sub-microsecond pulsed electric energy) to tissue, including cardiac tissue. The apparatus may include deployable electrodes that conform to transitional surfaces. These apparatuses may include single or multiple tiers of wire loops forming petal-like electrodes.

公开(公告)号：US20240139507A1

公开(公告)日：2024-05-02

申请号：US18406063

申请日：2024-01-05

申请人： Pulse Biosciences, Inc.

发明人： David J. DANITZ ,  Kevin L. MOSS ,  Wesley C. JOE ,  Christopher J. FOSTER ,  Gary L. BOSECK ,  Xitlalic Y. SOTO-SIDA ,  Robert MASTON ,  John P. LUNSFORD

IPC分类号： A61N1/36 ,  A61B34/35 ,  A61N1/04 ,  A61N1/06 ,  A61N1/08 ,  A61N1/375 ,  A61N1/378 ,  H03K3/02

CPC分类号： A61N1/36017 ,  A61B34/35 ,  A61N1/0476 ,  A61N1/048 ,  A61N1/06 ,  A61N1/08 ,  A61N1/3603 ,  A61N1/375 ,  A61N1/378 ,  H03K3/02 ,  A61B2034/301

摘要： Flexible catheters adapted to be inserted into a body to deliver high-voltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue may include a plurality of conductive layers, that may be coaxial. These catheters and method of using them to treat tissue are configured to reduce or avoid arcing.

公开(公告)号：US20230414941A1

公开(公告)日：2023-12-28

申请号：US18336907

申请日：2023-06-16

申请人： Pulse Biosciences, Inc.

发明人： Michael A. SMITH ,  Sukumar HIRANI ,  David J. DANITZ ,  Kevin L. MOSS ,  Anita L. CROMPTON

IPC分类号： A61N1/36

CPC分类号： A61N1/36014 ,  A61N1/328

摘要： Described here are methods and apparatuses, including templates and template systems, for accurately positioning electrode applicator tips in order to treat larger predefined patterns of tissue. Also described here are methods and apparatuses for positioning, e.g., orienting and/or spacing, applicator tip(s) against the tissue while applying energy through some or all of the electrodes in the applicator tip.

公开(公告)号：US20230248415A1

公开(公告)日：2023-08-10

申请号：US18186621

申请日：2023-03-20

申请人： Pulse Biosciences, Inc.

发明人： David J. DANITZ ,  Cameron D. HINMAN ,  Kenneth R. KRIEG ,  Kevin L. MOSS ,  Christopher J. FOSTER ,  Darrin R. UECKER

IPC分类号： A61B18/14

CPC分类号： A61B18/14 ,  A61B2018/00702 ,  A61B2018/1425

摘要： Described herein are methods and systems for using the treatment tip apparatuses and high-voltage connectors with robotic surgical systems. For example, retractable treatment tip apparatuses (e.g., devices, systems, etc.) including one, or more preferably a plurality, of electrodes that are protected by a housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment, are disclosed. In particular, these apparatuses may include a plurality of treatment needle electrodes and may be configured for the delivery of nanosecond pulsed electric fields. Also described herein are high-voltage connectors configured to provide high-voltage energy, such as nsPEF pulses, from a generator to the retractable treatment tip apparatuses.

公开(公告)号：US20230201572A1

公开(公告)日：2023-06-29

申请号：US18088157

申请日：2022-12-23

申请人： Pulse Biosciences, Inc.

发明人： Cameron D. Hinman ,  Kenneth R. Krieg

IPC分类号： A61N1/04 ,  A61N1/05

CPC分类号： A61N1/0496 ,  A61N1/0476 ,  A61N1/0502

摘要： To distribute electrical treatment to a treatment area of a patient, described herein are electrical therapy devices, methods of their operation and methods for delivery of the electrical therapy to the patient. In some embodiments, the electrical therapy device comprises an electrode assembly that includes at least two electrodes, and a conductive spacer positioned between the electrodes. Methods of selection of the electrical therapy devices and methods of their operation are also provided.

公开(公告)号：US11571569B2

公开(公告)日：2023-02-07

申请号：US16789350

申请日：2020-02-12

申请人： Pulse Biosciences, Inc.

发明人： David J. Danitz ,  Kevin L. Moss ,  Wesley C. Joe ,  Christopher J. Foster ,  Gary L. Boseck ,  Xitlalic Y. Soto-Sida ,  Robert Maston ,  John P. Lunsford

IPC分类号： A61N1/04 ,  A61N1/06 ,  A61N1/08 ,  A61N1/36 ,  A61N1/375 ,  A61B34/30 ,  A61B34/35 ,  H03K3/02 ,  A61N1/378

摘要： Flexible catheters adapted to be inserted into a body to deliver high-voltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue may include a plurality of conductive layers, that may be coaxial. These catheters and method of using them to treat tissue are configured to reduce or avoid arcing.

公开(公告)号：US20220370801A1

公开(公告)日：2022-11-24

申请号：US17881589

申请日：2022-08-04

申请人： Pulse Biosciences, Inc.

发明人： Chaofeng HUANG ,  Gregory P. SCHAADT ,  Kenneth R. KRIEG

IPC分类号： A61N1/36 ,  A61N1/04 ,  H01F27/24 ,  H01F27/28 ,  H03K3/353 ,  H05K1/18

摘要： Described herein are apparatuses and methods for applying high voltage, sub-microsecond (e.g., nanosecond range) pulsed output to a biological material, e.g., tissues, cells, etc., using a high voltage (e.g., MOSFET) gate driver circuit having a high voltage isolation and a low inductance. In particular, described herein are multi-core pulse transformers comprising independent transformer cores arranged in parallel on opposite sides of a substrate. The transformer cores may have coaxial primary and secondary windings. Also describe are pulse generators including multi-core pulse transformers arranged in parallel (e.g., on opposite sides of a PCB) to reduce MOSFET driver gate inductance.

公开(公告)号：US20210370049A1

公开(公告)日：2021-12-02

申请号：US17398637

申请日：2021-08-10

申请人： PULSE BIOSCIENCES, INC.

发明人： Kevin L. MOSS ,  Christopher J. FOSTER ,  Cameron D. HINMAN ,  David J. DANITZ ,  Darrin R. UECKER

IPC分类号： A61N1/05 ,  A61B34/37 ,  A61N1/40 ,  A61B34/32

摘要： Described herein are treatment tip apparatuses (e.g., devices, systems, etc.) including one, or more preferably a plurality, of electrodes that are protected by an electrode partition, such as an electrode housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment. In particular, these apparatuses may include a plurality of treatment electrodes (e.g., needle electrodes) and be configured for the delivery of nanosecond pulsed electric fields.

公开(公告)号：US20210038881A1

公开(公告)日：2021-02-11

申请号：US16980347

申请日：2019-03-11

申请人： PULSE BIOSCIENCES, INC.

发明人： Cameron D. HINMAN ,  Kevin L. MOSS ,  David J. DANITZ

IPC分类号： A61N1/05 ,  A61B34/30

摘要： Electrodes that are configured to apply energy within the tissue while moving relative to the tissue. The apparatuses (devices, assemblies, systems) described herein may be configured with one or more electrodes that may move slightly in oscillatory movement and/or rotation relative to the tissue. The apparatuses described herein may be used to apply energy to a patient while minimizing or preventing the unintended modification of the tissue adjacent to the electrode, such as by arcing.