-
公开(公告)号：US20140030792A1
公开(公告)日：2014-01-30
申请号：US13940122
申请日：2013-07-11
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N7/045 , C12N15/1131 , C12N2310/141 , C12N2740/16021 , C12N2740/16032 , C12N2740/16043 , C12N2740/16062
摘要： This invention provides therapeutic viruses (TV) and methods to inhibit the propagation of a target virus. TVs can be rendered noninfectious by inactivating mutations, but also include sequences providing miRNA to inactivate essential mRNAs of the target virus. Methods can include provision of the TV and contact with a host cell harboring the target virus. The target virus providing the essential enzymes necessary to the replication of the TV and the TV disabling the target virus with the miRNA.
摘要翻译： 本发明提供了治疗病毒（TV）和抑制靶病毒繁殖的方法。 电视可以通过灭活突变而变得非传染性，但也包括提供miRNA来灭活靶病毒的基本mRNA的序列。 方法可以包括提供电视并与携带目标病毒的宿主细胞接触。 提供复制电视和电视所需的必需酶的目标病毒能够使用miRNA抑制靶病毒。
-
公开(公告)号：US07491697B2
公开(公告)日：2009-02-17
申请号：US10579510
申请日：2004-12-01
申请人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
发明人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译： 本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。
-
公开(公告)号：US20070142278A1
公开(公告)日：2007-06-21
申请号：US10579510
申请日：2004-12-01
申请人： John Beals , Christopher Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Strifler , Radmila Micanovic
发明人： John Beals , Christopher Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Strifler , Radmila Micanovic
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译： 本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。
-
公开(公告)号：US20090118190A1
公开(公告)日：2009-05-07
申请号：US12349119
申请日：2009-01-06
申请人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
发明人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译： 本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。
-
公开(公告)号：US06835814B1
公开(公告)日：2004-12-28
申请号：US09936019
申请日：2001-09-07
IPC分类号： C07K14705
CPC分类号： C07K14/70578
摘要： The invention relates to FLINT analogs that are to proteolysis in vivo and in vitro at amino acid position 218 of mature FLINT, clinical and therapeutic uses thereof, and pharmaceutical formulations comprising said analogs.
摘要翻译： 本发明涉及在成熟FLINT的氨基酸位置218的体内和体外蛋白水解的FLINT类似物，其临床和治疗用途以及包含所述类似物的药物制剂。
-
公开(公告)号：US20070265200A1
公开(公告)日：2007-11-15
申请号：US10592016
申请日：2005-03-04
摘要： The invention provides FGF-21 compounds covalently attached to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active polypeptide with an extended elimination half-life and a slower clearance when compared to that of non-PEGylated polypeptide. These PEGylated FGF-21 compounds and compositions are useful in treating diabetes, obesity, and metabolic syndrome.
摘要翻译： 本发明提供与至少一种聚乙二醇分子或其衍生物共价连接的FGF-21化合物，当与非聚乙二醇化多肽相比时，产生具有延长的消除半衰期和较慢清除率的生物活性多肽。 这些聚乙二醇化FGF-21化合物和组合物可用于治疗糖尿病，肥胖症和代谢综合征。
-
公开(公告)号：US06965012B1
公开(公告)日：2005-11-15
申请号：US09936024
申请日：2000-03-20
申请人： Gerald Wayne Becker , Fredric Jay Cohen , Patricia Ann Gonzalez-DeWhitt , John Edward Hale , Radmila Micanovic , Christy Michelle Newton , Timothy Wayne Noblitt , Radhakrishnan Rathnachalam , Sheng-Hung Rainbow Tschang , Derrick Ryan Witcher , Victor John Wroblewski
发明人： Gerald Wayne Becker , Fredric Jay Cohen , Patricia Ann Gonzalez-DeWhitt , John Edward Hale , Radmila Micanovic , Christy Michelle Newton , Timothy Wayne Noblitt , Radhakrishnan Rathnachalam , Sheng-Hung Rainbow Tschang , Derrick Ryan Witcher , Victor John Wroblewski
IPC分类号： C07H21/04 , C07K14/705
CPC分类号： C07K14/70578 , C07H21/04 , C07K2319/30
摘要： Disclosed are polypeptide analogs of FLINT, polydeoxynucleotides encoding FLINT analogs, and methods of using FLINT analogs and polydeoxynucleotides. The FLINT analogs of the invention include polypeptides having the amino acid sequence of FLINT, modified at one or more positions with amino acid substitutions, and include fragments thereof, as well as Fc fusions comprising FLINT and FLINT analogs.
摘要翻译： 公开了FLINT的多肽类似物，编码FLINT类似物的多脱氧核苷酸，以及使用FLINT类似物和多脱氧核苷酸的方法。 本发明的FLINT类似物包括具有FLINT氨基酸序列的多肽，在一个或多个位置被修饰，具有氨基酸取代，并且包括其片段，以及包含FLINT和FLINT类似物的Fc融合体。
-
公开(公告)号：US06867198B2
公开(公告)日：2005-03-15
申请号：US10130493
申请日：2000-12-18
申请人： Rima Salim Al-Awar , Kyle Andrew Hecker , James Edward Ray , Jianping Huang , Sajan Joseph , Tiechao Li , Michael Paal , Radhakrishnan Rathnachalam , Chuan Shih , Philip Parker Waid , Xun Zhou , Guoxin Zhu
发明人： Rima Salim Al-Awar , Kyle Andrew Hecker , James Edward Ray , Jianping Huang , Sajan Joseph , Tiechao Li , Michael Paal , Radhakrishnan Rathnachalam , Chuan Shih , Philip Parker Waid , Xun Zhou , Guoxin Zhu
IPC分类号： C07D471/06 , C07D471/22 , C07D487/06 , C07D487/22 , C07D513/06 , C07D513/22 , C07F7/18 , C07H15/252 , A61K31/435 , A61K31/445
CPC分类号： C07D471/06 , C07D487/06 , C07D513/06 , C07F7/1804 , C07H15/252
摘要： The present invention provides selective kinase inhibitors of formula (I)
摘要翻译： 本发明提供了式（I）的选择性激酶抑制剂，
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.016 秒)