公开(公告)号：US20060040906A1

公开(公告)日：2006-02-23

申请号：US10526178

申请日：2003-09-05

申请人： Raman Bakshi ,  Ravi Nargund ,  Brenda Palucki ,  Min Park ,  Zhixiong Ye

发明人： Raman Bakshi ,  Ravi Nargund ,  Brenda Palucki ,  Min Park ,  Zhixiong Ye

IPC分类号： A61K31/551 ,  A61K31/496 ,  C07D403/02

CPC分类号： C07D401/12 ,  C07D211/18 ,  C07D211/22 ,  C07D211/62 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity and diabetes.

摘要翻译： 某些新型哌嗪脲衍生物是人类黑皮质素-4受体（MC-4R）的激动剂，特别是MC-4R的受体亚型选择性激动剂。 它们可用于治疗，控制或预防对MC-4R活化反应的疾病和病症，例如肥胖症和糖尿病。

公开(公告)号：US20060035935A1

公开(公告)日：2006-02-16

申请号：US11239721

申请日：2005-09-30

申请人： Mark Goulet ,  Ravi Nargund ,  Iyassu Sebhat ,  Feroze Ujjainwalla ,  Thomas Walsh ,  Daniel Warner ,  Zhixiong Ye ,  Jonathan Young ,  Raman Bakshi

发明人： Mark Goulet ,  Ravi Nargund ,  Iyassu Sebhat ,  Feroze Ujjainwalla ,  Thomas Walsh ,  Daniel Warner ,  Zhixiong Ye ,  Jonathan Young ,  Raman Bakshi

IPC分类号： A61K31/454 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02 ,  C07D401/02

CPC分类号： C07D491/08 ,  A61K31/445 ,  C07D211/62 ,  C07D211/64 ,  C07D401/06 ,  C07D401/14 ,  C07D413/06 ,  C07D413/14

摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

公开(公告)号：US20070191433A1

公开(公告)日：2007-08-16

申请号：US11632000

申请日：2005-07-15

申请人： Raman Bakshi ,  James Dellureficio ,  Ravi Nargund

发明人： Raman Bakshi ,  James Dellureficio ,  Ravi Nargund

IPC分类号： A61K31/454 ,  C07D403/02

CPC分类号： C07D401/06 ,  C07D211/62 ,  C07D401/14 ,  C07D413/14

摘要： Certain novel N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

摘要翻译： 某些新的N-酰化哌啶衍生物是人类黑皮质素受体的激动剂，特别是人黑皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的激活反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。

公开(公告)号：US20100184758A1

公开(公告)日：2010-07-22

申请号：US12668822

申请日：2008-07-15

申请人： Peter H. Dobbelaar ,  Wu Du ,  Liangqin Guo ,  William K. Hagmann ,  Shuwen He ,  Tianying Jian ,  Jian Liu ,  Ravi P. Nargund ,  Alexander Pasternak ,  Shrenik K. Shah ,  Quang T. Truong ,  Zhixiong Ye ,  James Deliureficio ,  Raman Bakshi

发明人： Peter H. Dobbelaar ,  Wu Du ,  Liangqin Guo ,  William K. Hagmann ,  Shuwen He ,  Tianying Jian ,  Jian Liu ,  Ravi P. Nargund ,  Alexander Pasternak ,  Shrenik K. Shah ,  Quang T. Truong ,  Zhixiong Ye ,  James Deliureficio ,  Raman Bakshi

IPC分类号： A61K31/5377 ,  C07D471/14 ,  A61K31/437 ,  C07D413/14 ,  C07D403/14 ,  A61K31/501 ,  A61K31/4995 ,  A61K31/506 ,  A61P3/10 ,  A61P3/04 ,  A61P3/00 ,  A61P3/06 ,  A61P9/12

CPC分类号： C07D471/04

摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

摘要翻译： 结构式I的β-咔啉衍生物是生长抑素亚型受体3（SSTR3）的选择性拮抗剂，可用于治疗2型糖尿病和通常与该疾病相关的病症，包括高血糖症，胰岛素抵抗，肥胖症， 脂质障碍和高血压。 这些化合物也可用于治疗抑郁症和焦虑症。