利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.016 秒)

    THREE DIMENSIONAL MICROELECTRODE SYSTEM FOR DIELECTROPHORESIS
    1.
    发明申请
    THREE DIMENSIONAL MICROELECTRODE SYSTEM FOR DIELECTROPHORESIS 有权
    三维微电子系统用于电介质

    公开(公告)号：US20130306481A1

    公开(公告)日：2013-11-21

    申请号：US13945768

    申请日：2013-07-18

    申请人： Dietrich A. Dehlinger ,  Klint A. Rose ,  Maxim Shusteff ,  Christopher G. Bailey ,  Raymond P. Mariella, JR.

    发明人： Dietrich A. Dehlinger ,  Klint A. Rose ,  Maxim Shusteff ,  Christopher G. Bailey ,  Raymond P. Mariella, JR.

    IPC分类号： B03C5/00

    CPC分类号： B03C5/005 ,  B01L2400/0424 ,  B03C5/026 ,  G01N27/447

    摘要： A dielectrophoresis apparatus for separating particles from a sample, including an apparatus body; a dielectrophoresis channel in the apparatus body, the dielectrophoresis channel having a central axis, a bottom, a top, a first side, and a second side; a first mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the first mesa extending at an angle to the central axis of the dielectrophoresis channel; a first electrode extending along the first mesa; a second mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the second mesa extending at an angle to the central axis of the dielectrophoresis channel; a space between at least one of the first electrode and the second side or the second electrode and the second side; and a gap between the first electrode and the second electrode.

    摘要翻译： 一种用于从样品中分离颗粒的介电电泳装置，包括装置体; 所述设备主体中的介电电泳通道，所述介电电泳通道具有中心轴线，底部，顶部，第一侧面和第二侧面; 第一台面从底部突出到介电电泳通道中并且从第一侧穿过介电电泳通道延伸到第二侧，第一台面以与介电电泳通道的中心轴线成一定角度延伸; 沿第一台面延伸的第一电极; 从底部突出到介电电泳通道的第二台面，并且从第一侧穿过介电电泳通道延伸到第二侧，第二台面以与介电电泳通道的中心轴线成一定角度延伸; 第一电极和第二电极和第二电极和第二侧中的至少一个之间的空间; 以及第一电极和第二电极之间的间隙。

    Isotachophoresis System Having Larger-Diameter Channels Flowing Into Channels With Reduced Diameter And With Selectable Counter-Flow
    2.
    发明申请
    Isotachophoresis System Having Larger-Diameter Channels Flowing Into Channels With Reduced Diameter And With Selectable Counter-Flow 有权
    具有较大直径通道的等速电泳系统流入具有减小的直径和可选的逆流的通道

    公开(公告)号：US20120175258A1

    公开(公告)日：2012-07-12

    申请号：US13105984

    申请日：2011-05-12

    申请人： Raymond P. Mariella, JR.

    发明人： Raymond P. Mariella, JR.

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44773

    摘要： An isotachophoresis system for separating a sample containing particles into discrete packets including a flow channel, the flow channel having a large diameter section and a small diameter section; a negative electrode operably connected to the flow channel; a positive electrode operably connected to the flow channel; a leading carrier fluid in the flow channel; a trailing carrier fluid in the flow channel; and a control for separating the particles in the sample into discrete packets using the leading carrier fluid, the trailing carrier fluid, the large diameter section, and the small diameter section.

    摘要翻译： 一种等离子电泳系统，用于将含有颗粒的样品分离成包括流动通道的离散分组，所述流动通道具有大直径部分和小直径部分; 可操作地连接到流动通道的负极; 可操作地连接到流动通道的正电极; 流动通道中的引导载体流体; 流动通道中的拖尾载体流体; 以及使用前导载体流体，尾部流体，大直径部分和小直径部分将样品中的颗粒分离成离散的分组的控制。

    Synthesis of DNA
    3.
    发明授权
    Synthesis of DNA 失效
    DNA的合成

    公开(公告)号：US07452666B2

    公开(公告)日：2008-11-18

    申请号：US10394911

    申请日：2003-03-21

    申请人： Raymond P. Mariella, Jr.

    发明人： Raymond P. Mariella, Jr.

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12N15/1031 ,  C07H21/00 ,  C12N15/1027 ,  C12Q1/686 ,  C12Q2533/107 ,  C12Q2521/101

    摘要： A method of synthesizing a desired double-stranded DNA of a predetermined length and of a predetermined sequence. Preselected sequence segments that will complete the desired double-stranded DNA are determined. Preselected segment sequences of DNA that will be used to complete the desired double-stranded DNA are provided. The preselected segment sequences of DNA are assembled to produce the desired double-stranded DNA.

    摘要翻译： 合成预定长度和预定序列的所需双链DNA的方法。 确定将完成所需双链DNA的预选序列片段。 提供将用于完成所需双链DNA的预选择的DNA序列。 组装DNA的预选区段序列以产生所需的双链DNA。

    Stepped electrophoresis for movement and concentration of DNA
    7.
    发明授权
    Stepped electrophoresis for movement and concentration of DNA 失效
    步进电泳DNA的移动和浓缩

    公开(公告)号：US06866759B2

    公开(公告)日：2005-03-15

    申请号：US09738462

    申请日：2000-12-13

    申请人： Robin R. Miles ,  Amy Wei-Yun Wang ,  Raymond P. Mariella, Jr.

    发明人： Robin R. Miles ,  Amy Wei-Yun Wang ,  Raymond P. Mariella, Jr.

    IPC分类号： G01N27/447 ,  G01N27/453

    CPC分类号： G01N27/44773

    摘要： A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is caused to move. By using a series of electrodes, when one electrode voltage or charge is made negative with respect to adjacent electrodes, the DNA is repelled away from this electrode and attached to a positive charged electrode of the series. By sequentially making the next electrode of the series negative, the DNA can be moved to and concentrated over the remaining positive electrodes.

    摘要翻译： 用一系列薄膜电极图案化的流体通道使得可以将DNA移动并浓缩在通过流体通道的流体中。 DNA具有固有的负电荷，并且通过在相邻电极之间施加电压使DNA发生移动。 通过使用一系列电极，当相对于相邻电极使一个电极电压或电荷为负极时，DNA将从该电极排出并附着到该串联的正带电电极。 通过顺序地使串联的下一个电极为阴性，DNA可以移动到其余正极上并集中在剩余的正电极上。

    Three dimensional separation trap based on dielectrophoresis and use thereof
    8.
    发明授权
    Three dimensional separation trap based on dielectrophoresis and use thereof 失效
    基于介电电泳的三维分离阱及其应用

    公开(公告)号：US06730204B2

    公开(公告)日：2004-05-04

    申请号：US09819110

    申请日：2001-03-27

    申请人： Raymond P. Mariella, Jr.

    发明人： Raymond P. Mariella, Jr.

    IPC分类号： G01N27447

    CPC分类号： B03C5/026

    摘要： An apparatus is adapted to separate target materials from other materials in a flow containing the target materials and other materials. A dielectrophoretic trap is adapted to receive the target materials and the other materials. At least one electrode system is provided in the trap. The electrode system has a three-dimensional configuration. The electrode system includes a first electrode and a second electrode that are shaped and positioned relative to each such that application of an electrical voltage to the first electrode and the second electrode creates a dielectrophoretic force and said dielectrophoretic force does not reach zero between the first electrode and the second electrode.

    摘要翻译： 一种装置适于在包含目标材料和其它材料的流中将目标材料与其他材料分离。 介电电泳捕集器适于接收目标材料和其他材料。 在陷阱中提供至少一个电极系统。 电极系统具有三维结构。 所述电极系统包括第一电极和第二电极，所述第一电极和第二电极相对于每个电极和第二电极成形和定位，使得向所述第一电极和所述第二电极施加电压产生介电电泳力，并且所述介电电泳力在所述第一电极 和第二电极。

    Photodetector having high speed and sensitivity
    9.
    发明授权
    Photodetector having high speed and sensitivity 失效
    光电检测器具有高速度和灵敏度

    公开(公告)号：US5051804A

    公开(公告)日：1991-09-24

    申请号：US444339

    申请日：1989-12-01

    申请人： Jeffrey D. Morse ,  Raymond P. Mariella, Jr.

    发明人： Jeffrey D. Morse ,  Raymond P. Mariella, Jr.

    IPC分类号： H01L31/0304 ,  H01L31/08 ,  H01L31/09

    CPC分类号： H01L31/03046 ,  H01L31/085 ,  H01L31/09 ,  Y02E10/544

    摘要： The present invention provides a photodetector having an advantageous combination of sensitivity and speed; it has a high sensitivity while retaining high speed. In a preferred embodiment, visible light is detected, but in some embodiments, x-rays can be detected, and in other embodiments infrared can be detected. The present invention comprises a photodetector having an active layer, and a recombination layer. The active layer has a surface exposed to light to be detected, and comprises a semiconductor, having a bandgap graded so that carriers formed due to interaction of the active layer with the incident radiation tend to be swept away from the exposed surface. The graded semiconductor material in the active layer preferably comprises Al.sub.1-x Ga.sub.x As. An additional sub-layer of graded In.sub.1-y Ga.sub.y As may be included between the Al.sub.1-x Ga.sub.x As layer and the recombination layer. The recombination layer comprises a semiconductor material having a short recombination time such as a defective GaAs layer grown in a low temperature process. The recombination layer is positioned adjacent to the active layer so that carriers from the active layer tend to be swept into the recombination layer. In an embodiment, the photodetector may comprise one or more additional layers stacked below the active and recombination layers. These additional layers may include another active layer and another recombination layer to absorb radiation not absorbed while passing through the first layers. A photodetector having a stacked configuration may have enhanced sensitivity and responsiveness at selected wavelengths such as infrared.

    摘要翻译： 本发明提供了具有灵敏度和速度的有利组合的光电检测器; 它具有高灵敏度，同时保持高速度。 在优选实施例中，检测到可见光，但是在一些实施例中，可以检测x射线，并且在其它实施例中可以检测到红外线。 本发明包括具有活性层的光电检测器和复合层。 有源层具有暴露于待检测光的表面，并且包括半导体，具有带隙分级，使得由于活性层与入射辐射的相互作用而形成的载流子倾向于从暴露表面扫过。 活性层中的分级半导体材料优选包含Al1-xGaxA。 在Al1-xGaxAs层和复合层之间可以包括附加的分级In1-yGayAs子层。 复合层包括具有短复合时间的半导体材料，例如在低温工艺中生长的不良GaAs层。 复合层定位成与有源层相邻，使得来自有源层的载流子倾向于被扫入复合层。 在一个实施例中，光电检测器可以包括在活性和复合层之下堆叠的一个或多个附加层。 这些附加层可以包括另一个活性层和另一个复合层，以吸收在通过第一层时不被吸收的辐射。 具有堆叠配置的光电检测器可以具有增强的灵敏度和选择的波长例如红外线的响应性。

    Isotope separation by solar photoionization
    10.
    发明授权
    Isotope separation by solar photoionization 失效
    通过太阳光电离分离同位素

    公开(公告)号：US4320300A

    公开(公告)日：1982-03-16

    申请号：US79751

    申请日：1979-09-28

    申请人： Raymond P. Mariella, Jr.

    发明人： Raymond P. Mariella, Jr.

    IPC分类号： B01D59/34 ,  B01J19/12 ,  H01J49/16 ,  B01J1/10 ,  H01J39/34

    CPC分类号： H01J49/162 ,  B01D59/34 ,  B01J19/12

    摘要： Isotope separation, particularly separation of isotopes of lithium, is achieved by exposing a beam of atoms to radiation that selectively excites atoms of a particular isotope without exciting atoms of other isotopes of that element. The excited atoms are ionized by solar radiation and the ions attracted to an ion collector plate maintained at a negative potential. The atoms not ionized are condensed on a grounded atom collector plate. Optionally, the solar radiation not absorbed by the system may be used to generate electricity. Lithium isotopes are useful in nuclear reactors and nuclear weapons.

    摘要翻译： 通过将原子束暴露于选择性地激发特定同位素的原子而不激发该元素的其它同位素的原子的辐射，实现同位素分离，特别是锂同位素的分离。 激发的原子被太阳辐射电离，吸附到离子收集板的离子保持在负电位。 未离子化的原子在接地的原子收集板上凝结。 可选地，不被系统吸收的太阳辐射可以用于发电。 锂同位素可用于核反应堆和核武器。