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    Treatment of heart rhythm disorders by administration of 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds.
    4.
    发明授权
    Treatment of heart rhythm disorders by administration of 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds. 失效
    通过给予3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗心律紊乱。

    公开(公告)号：US5635511A

    公开(公告)日：1997-06-03

    申请号：US594946

    申请日：1996-01-31

    申请人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

    发明人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

    IPC分类号： A61K31/435 ,  A61K31/439 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D471/08 ,  C07D471/10 ,  A61K31/44

    CPC分类号： C07D471/08 ,  C07D471/10

    摘要： The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhytmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R.sup.1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms,R.sup.2 is lower alkyl, andR.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain having 3-6 carbon atoms,R.sup.4' is cyano, an R.sup.6 --O--CO-- group in which R.sup.6 is lower alkyl, an R.sup.7 --SO.sub.2 --NH-- group in which R.sup.7 is lower alkyl, or an R.sup.8 --CO--NH-- group in which R.sup.8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro, or an R.sup.9 --SO.sub.2 -- radical in which R.sup.9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, andR.sup.5 is hydrogen or halogen,and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.

    摘要翻译： 使用3,7,9,9-四取代的3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗大型哺乳动物，包括人类的心脏病变; 对应于其中R 1为具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基的通式Ia Ia的新型抗心律失活的3,7,9,9-四取代化合物，R2较低 烷基，R3为低级烷基，或R2和R3一起形成3-6个碳原子的亚烷基链，R4'为氰基，R6为低级烷基的R6-O-CO-基团，R7-SO2-NH - 其中R 7为低级烷基的基团，或其中R 8为低级烷基的R 8 -CO-NH基或任选被卤素，氰基，硝基或R 9 -SO 2 - 基团取代的苯基，其中R 9为 低级烷基或位于苯环4位的咪唑基，R5为氢或卤素，以及其生理上可接受的酸加成盐，以及制备它们的方法和中间体。

    Treatment of heart rhythym disorders by administration of 3-phenylsulfonyl-3, 7-diazabicyclo[3.3.1]nonane compounds
    5.
    发明授权
    Treatment of heart rhythym disorders by administration of 3-phenylsulfonyl-3, 7-diazabicyclo[3.3.1]nonane compounds 失效
    通过给予3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗心律失调症

    公开(公告)号：US5576327A

    公开(公告)日：1996-11-19

    申请号：US382262

    申请日：1995-02-01

    申请人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

    发明人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

    IPC分类号： A61K31/435 ,  A61K31/439 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D471/08 ,  C07D471/10

    CPC分类号： C07D471/08 ,  C07D471/10

    摘要： The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhythmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R.sup.1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms,R.sup.2 is lower alkyl, andR.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain having 3-6 carbon atoms,R.sup.4 ' is cyano, an R.sup.6 --O--CO-- group in which R.sup.6 is lower alkyl, an R.sup.7 --SO.sub.2 --NH-- group in which R.sup.7 is lower alkyl, or an R.sup.8 --CO--NH-- group in which R.sup.8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro or an R.sup.9 --SO.sub.2 -- radical in which R.sup.9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, andR.sup.5 is hydrogen or halogen,and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.

    摘要翻译： 使用3,7,9,9-四取代的3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗大型哺乳动物，包括人类的心律失常; 对应于其中R 1为具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基的通式Ia Ia的新型抗心律失活的3,7,9,9-四取代化合物，R2较低 烷基，R3为低级烷基，或R2和R3一起形成3-6个碳原子的亚烷基链，R4'为氰基，R6为低级烷基的R6-O-CO-基团，R7-SO2-NH - 其中R 7为低级烷基的基团，或其中R 8为低级烷基的R 8 -CO-NH-基团或任选被卤素，氰基，硝基或R 9 -SO 2 - 基团取代的苯基，其中R 9为低级 烷基或位于苯环4位的咪唑基，R5为氢或卤素，以及其生理上可接受的酸加成盐，以及其制备方法和中间体。

    7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them
    8.
    发明授权
    7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them 有权
    7-苯基-1,4-二氮杂环丁烷化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US6040303A

    公开(公告)日：2000-03-21

    申请号：US141312

    申请日：1998-08-27

    申请人： Samuel David ,  Jochen Antel ,  Reinhard Brueckner ,  Dieter Ziegler ,  Christian Eeckhout ,  Gerhard-Wilhelm Bielenberg ,  Michael Peck

    发明人： Samuel David ,  Jochen Antel ,  Reinhard Brueckner ,  Dieter Ziegler ,  Christian Eeckhout ,  Gerhard-Wilhelm Bielenberg ,  Michael Peck

    IPC分类号： A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

    CPC分类号： C07D243/08 ,  Y02P20/55

    摘要： Neurokinin-antagonistic compounds corresponding to formula I: ##STR1## in which R.sup.1 is hydrogen or lower alkyl,R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.2 and R.sup.3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.4 and R.sup.5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.6 is lower alkyl, halogen or trifluoromethyl,R.sup.7 is lower alkyl, halogen or trifluoromethyl,A is a --(CH.sub.2).sub.n -- group in which n represents an integer from 1 to 3, or an --NH--(CH.sub.2).sub.m -- group in which m represents an integer from 2 to 3, andB is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl,and physiologically acceptable salts thereof and processes for the preparation of these compounds.

    摘要翻译： 对应于式I的神经激肽拮抗化合物：其中R1是氢或低级烷基，R2是氢，低级烷基，低级烷氧基，卤素或三氟甲基，R3是氢，低级烷基，低级烷氧基，卤素或三氟甲基，或R2和 R3一起是具有1至2个碳原子的亚烷基二氧基，与苯环的相邻碳原子键合，R4是氢，低级烷基，低级烷氧基，卤素或三氟甲基，R5是氢，低级烷基，低级烷氧基，卤素或三氟甲基， 或R4和R5一起是具有1至2个碳原子的亚烷基二氧基，与苯环的相邻碳原子键合，R6是低级烷基，卤素或三氟甲基，R7是低级烷基，卤素或三氟甲基，A是 - （CH2）n - 其中n表示1至3的整数的基团，或其中m表示2至3的整数的-NH-（CH 2）m - 基团，B是具有1至3个碳原子的亚烷基链，其任选被 低级烷基和其生理上可接受的盐 d制备这些化合物的方法。