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    Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
    6.
    发明授权
    Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them 失效
    [2-（8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1（7） - 烯-2-基）烷基]膦酸的衍生物及其制备方法

    公开(公告)号：US07268123B2

    公开(公告)日：2007-09-11

    申请号：US11244599

    申请日：2005-10-06

    申请人： Reinhardt Bernhard Baudy

    发明人： Reinhardt Bernhard Baudy

    IPC分类号： A61P25/00 ,  A61K31/675 ,  C07D223/00

    CPC分类号： A61K31/551 ,  C07F9/645

    摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of —C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1 and R2 is not hydrogen; R3 is, independently, hydrogen, —OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.

    摘要翻译： 提供式（I）化合物或其药学上可接受的盐：其中：A为1至4个碳原子的亚烷基或2至4个碳原子的烯基; R 1和R 2独立地是氢或任选被1个碳原子的C 5至C 7芳基取代的C 7 至2个取代基，独立地选自-C（O）R 3，卤素，氰基，硝基，羟基，C 1 -C 6 C 1 -C 6烷基和C 1 -C 6烷氧基，条件是R 1和R 2中的至少一个是烷基， 2不是氢; R 3独立地为氢，-OR 4，烷基，芳基或杂芳基; R 4是氢，烷基，芳基或杂芳基; R 5和R 6独立地是氢，烷基，羟基，烷氧基或C 5至C 7 芳基; 其中具有芳基或杂芳基部分的任何R 3至R 6基团可任选地在芳基或杂芳基部分上与1至约5个取代基取代，独立地选自 由卤素，氰基，硝基，羟基，C 1 -C 6烷基和C 1 -C 6烷基组成的基团， 烷氧基。 还公开了制备这些化合物的方法以及使用该化合物处理各种条件的方法。

    Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
    10.
    发明授权
    Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them 失效
    [2-（8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1（7） - 烯-2-基）烷基]膦酸的衍生物及其制备方法

    公开(公告)号：US07879826B2

    公开(公告)日：2011-02-01

    申请号：US11758459

    申请日：2007-06-05

    申请人： Reinhardt Bernhard Baudy

    发明人： Reinhardt Bernhard Baudy

    IPC分类号： A61P25/00 ,  A61K31/675 ,  C07D223/00

    CPC分类号： A61K31/551 ,  C07F9/645

    摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of —C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1 and R2 is not hydrogen; R3 is, independently, hydrogen, —OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.

    摘要翻译： 提供式（I）化合物或其药学上可接受的盐：其中：A为1至4个碳原子的亚烷基或2至4个碳原子的烯基; R 1和R 2独立地是氢或任选被1至2个取代基取代的C 5至C 7芳基，独立地选自-C（O）R 3，卤素，氰基，硝基，羟基，C 1 -C 6烷基， 和C 1 -C 6烷氧基，条件是R 1和R 2中的至少一个不是氢; R 3独立地是氢，-OR 4，烷基，芳基或杂芳基; R4是氢，烷基，芳基或杂芳基; R 5和R 6独立地是氢，烷基，羟基，烷氧基或C 5至C 7芳基; 其中具有芳基或杂芳基部分的任何R 3至R 6基团可任选地在芳基或杂芳基部分上与1至约5个取代基取代，独立地选自卤素，氰基，硝基，羟基，C 1 -C 6烷基， 和C 1 -C 6烷氧基。 还公开了制备这些化合物的方法以及使用该化合物处理各种条件的方法。