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公开(公告)号：US07825160B2
公开(公告)日：2010-11-02
申请号：US11665760
申请日：2005-10-21
申请人： Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
发明人： Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
IPC分类号： A01N37/10 , A61K31/19 , A01N37/08 , A01N53/00 , A61K31/557 , C07C63/00 , C07C65/00 , C07C63/33 , C07C63/333 , C07C61/04 , C07C61/16 , C07C62/00
CPC分类号： C07C59/68 , C07C59/72 , C07C233/54 , C07C235/42 , C07C311/29 , C07C317/22 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07D261/08 , C07D295/192 , C07D295/26 , C07D309/06
摘要： The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译： 本发明涉及具有通式（I）的具有下述A，X，R 1 -R 6的定义的化合物和/或其盐或酯。 此外，本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号：US20070254957A1
公开(公告)日：2007-11-01
申请号：US11737475
申请日：2007-04-19
申请人： Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Ho
发明人： Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Ho
IPC分类号： A61K31/192 , C07C59/40 , C07C62/30
CPC分类号： C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译： 本发明涉及具有通式（I）的化合物，其具有X，Y，R 1，R 2，R 3，R 3， R 4，R 9，R 10，及其溶剂合物，水合物，酯和药学上可接受的盐。 此外，本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号：US08106236B2
公开(公告)日：2012-01-31
申请号：US11737475
申请日：2007-04-19
申请人： Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Yung Ho
发明人： Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Yung Ho
IPC分类号： C07C63/00
CPC分类号： C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof.Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译： 本发明涉及具有以下给出的X，Y，R 1，R 2，R 3，R 4，R 9，R 10的定义的通式（I）的化合物及其溶剂化物，水合物，酯和药学上可接受的盐。 此外，本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号：US20090118289A1
公开(公告)日：2009-05-07
申请号：US11665760
申请日：2005-10-21
申请人： Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
发明人： Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
IPC分类号： A61K31/19 , C07C59/68 , C07D207/12 , C07D261/06 , C07D265/30 , A61P25/28 , A61K31/5375 , A61K31/40 , A61K31/42
CPC分类号： C07C59/68 , C07C59/72 , C07C233/54 , C07C235/42 , C07C311/29 , C07C317/22 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07D261/08 , C07D295/192 , C07D295/26 , C07D309/06
摘要： The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译： 本发明涉及具有通式（I）的具有下述A，X，R 1 -R 6的定义的化合物和/或其盐或酯。 此外，本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号：US20070293567A1
公开(公告)日：2007-12-20
申请号：US11737938
申请日：2007-04-20
申请人： Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Ho , Yan Zhang
发明人： Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Ho , Yan Zhang
IPC分类号： A61K31/196 , A61K31/24 , A61P25/28 , C07C229/28
CPC分类号： C07C229/42 , C07C59/68
摘要： The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译： 本发明涉及具有通式（I）的化合物，其具有X，Y，R 1，R 2，R 3， ，R 4 R 9和R 10，和/或其盐或酯。 此外，本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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