公开(公告)号：US20110105554A1

公开(公告)日：2011-05-05

申请号：US12744282

申请日：2008-11-21

申请人： Dietmar Manstein ,  Roman Fedorov ,  Georgios Tsiavaliaris ,  Hans-Joachim Knölker ,  René Martin ,  Juliane Kirst ,  Herwig Gutzeit ,  Markus Böhl

发明人： Dietmar Manstein ,  Roman Fedorov ,  Georgios Tsiavaliaris ,  Hans-Joachim Knölker ,  René Martin ,  Juliane Kirst ,  Herwig Gutzeit ,  Markus Böhl

IPC分类号： A61K31/473 ,  C07D207/30 ,  C07D333/08 ,  C07D307/02 ,  C07D209/82 ,  C07D219/04 ,  A61K31/40 ,  A61K31/381 ,  A61K31/341 ,  A61K31/403 ,  G06G7/48 ,  G01N33/566

CPC分类号： A61K31/33 ,  C07K2299/00 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A90/26

摘要： The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selected from (a) ranges K265-V268, V411-L441, N588-Q593, D614-T629, and V630-E646 of SEQ ID NO: 2, said myosin comprising or consisting of (i) the sequence of SEQ ID NO: 2; (ii) the sequence encoded by the sequence of SEQ ID NO: 1; (iii) a sequence being at least 40% identical to the sequence of SEQ ID NO: 2 or to the sequence encoded by the sequence of SEQ ID NO: 1; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of SEQ ID NO: 1; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise K265; or (b) ranges of any one of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106 or 108, respectively, said ranges aligning with the ranges of SEQ ID NO: 2 as defined in (a), said myosin comprising or consisting of (i) the sequence of any one of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106 or 108, respectively; (ii) the sequence encoded by the sequence of any one of SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 or 109; respectively; (iii) a sequence being at least 40% identical to the sequence of any one of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106 or 108, respectively, or to the sequence encoded by the sequence of any one of SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 or 109, respectively; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of any one of SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 or 109, respectively; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise the residue aligning with K265 of SEQ ID NO: 2; thereby obtaining said modulator of a myosin. Furthermore provided are a method of identifying a modulator of a myosin, pharmaceutical compositions and methods of treating cardiovascular diseases, cancer, diseases of the central nervous system, viral infections, and infections by parasites of the Apicomplexa family.

公开(公告)号：US08627406B2

公开(公告)日：2014-01-07

申请号：US11831528

申请日：2007-07-31

申请人： René Martin ,  Alain Filée

发明人： René Martin ,  Alain Filée

IPC分类号： G06F21/00

CPC分类号： G06F21/57 ,  G06F21/64 ,  G06F21/78

摘要： A security and protection device (1) for protection of the data and executable codes of any fixed or portable computer system and that has a memory medium to be protected. The security and protection device (1) is located physically between the computer system (2) and the memory medium (MP) to be protected, in order to allow the computer system (2) access to the data and codes to be protected after execution of the protection functions independently of the machine code executed by the computer system (2) and requires no interaction with the processor of the system for the execution of these functions.

摘要翻译： 一种用于保护任何固定或便携式计算机系统的数据和可执行代码并且具有要被保护的存储介质的安全和保护装置（1）。 安全和保护装置（1）物理地位于要保护的计算机系统（2）和存储介质（MP）之间，以便允许计算机系统（2）在执行之后访问要保护的数据和代码 的保护功能独立于由计算机系统（2）执行的机器代码，并且不需要与用于执行这些功能的系统的处理器的交互。

公开(公告)号：US06475728B1

公开(公告)日：2002-11-05

申请号：US09424877

申请日：2000-03-31

申请人： Jean-René Martin ,  Eliane Souteyrand

发明人： Jean-René Martin ,  Eliane Souteyrand

IPC分类号： G01N2726

CPC分类号： C12Q1/6825 ,  G01N27/305 ,  G01N33/5438

摘要： An apparatus and method for identifying and/or quantifying a charged biological substance in a conductive liquid medium.

摘要翻译： 用于识别和/或定量导电液体介质中的带电生物物质的装置和方法。

公开(公告)号：US08341389B2

公开(公告)日：2012-12-25

申请号：US12319444

申请日：2009-01-07

申请人： Alain Filee ,  René Martin

发明人： Alain Filee ,  René Martin

IPC分类号： G06F9/00 ,  G06F15/177

CPC分类号： G06F21/575 ,  G06F21/34 ,  G06F21/72

摘要： A device for the secured start-up of a computer installation comprising a first connection interface to the computer installation and a second connection interface to an external data medium unit separate from the computer installation and which contains data and executable codes for a start-up program of the computer installation. The device also includes means for securing the use of data and executable codes and for transmitting data and executable codes of the start-up program from the external data medium unit via the second connection interface to the computer installation via the first connection interface, and after executing the means of security, to start-up the computer installation using transmitted executable codes and data.

摘要翻译： 一种用于安全启动计算机设备的设备，包括到计算机设备的第一连接接口和与计算机设备分离的外部数据介质单元的第二连接接口，并且包含用于启动程序的数据和可执行代码 的电脑安装。 该装置还包括用于确保数据和可执行代码的使用以及用于经由第一连接接口将启动程序的数据和可执行代码从外部数据介质单元经由第二连接接口发送到计算机设备的装置，以及之后 执行安全手段，使用传输的可执行代码和数据启动计算机安装。

公开(公告)号：US06979540B2

公开(公告)日：2005-12-27

申请号：US10181636

申请日：2001-01-17

申请人： Bernard Benneteau ,  Jamal Bousbaa ,  Franck Choplin ,  Eliane Souteyrand ,  Jean-René Martin ,  Jean-Pierre Cloarec

发明人： Bernard Benneteau ,  Jamal Bousbaa ,  Franck Choplin ,  Eliane Souteyrand ,  Jean-René Martin ,  Jean-Pierre Cloarec

IPC分类号： G01N33/53 ,  C07B61/00 ,  C07H21/00 ,  C12N15/09 ,  C40B40/06 ,  G01N33/543 ,  G01N37/00 ,  G01Q70/18 ,  G01Q80/00 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07H21/00 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  C07B2200/11 ,  C40B40/06

摘要： This invention concerns the use, for synthesizing and immobilising nucleic acids, of a solid support modified by an organized self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesizing and immobilizing nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.

摘要翻译： 本发明涉及用于合成和固定核酸的通过一种或多种有机硅化合物的有组织的自组装单层修饰的固体支持物的用途。 本发明还涉及在这种硅烷化固体支持物上合成和固定核酸的方法以及通过所述方法获得的DNA芯片。

公开(公告)号：US20110132191A1

公开(公告)日：2011-06-09

申请号：US12957468

申请日：2010-12-01

申请人： Andreas FREDENHAGEN ,  René MARTIN ,  Michael FEISTHAUER ,  Michael ROHDENBURG

发明人： Andreas FREDENHAGEN ,  René MARTIN ,  Michael FEISTHAUER ,  Michael ROHDENBURG

IPC分类号： B01D53/02

CPC分类号： B01D53/06 ,  B01D53/261 ,  B01D2257/80

摘要： An adsorption drying apparatus, in particular for drying a compressed gas, includes an adsorption chamber (11) having a plurality of adsorption conduits (101) containing an adsorption material (123), a first feeding line (106) and a first discharging line (109) disposed at a first end (111) of the adsorption chamber (11), and a second feeding line (108) and a second discharging line (107) disposed at a second end (112) of the adsorption chamber (11). The adsorption chamber (11) is rotatable with respect to the feeding and discharging lines (106, 107, 108, 109) so that the adsorption conduits may be fluidically connected in temporal alternation, wherein the gas is dried in a drying sector (102), and the adsorption material (123) is regenerated in the regeneration sector (103). The first feeding line (106) is configured such that the gas stream to be dried may be fed to the regeneration sector (103) as a full flow. The second discharging line (107) is in communication with the second feeding line (108) and thus forms a connecting line in which a condenser is provided, and a pressure increasing device (18) is provided within the connecting line so as to increase the pressure of the gas flowing from the second discharging line (107) to the second feeding line (108). A cooling stream may be branched off at the first (111) or second end (112) of the adsorption chamber (11), as need be, to cool the adsorption chamber (11) within the cooling sector (119). The regeneration sector (103) and the drying sector (102) are connected in cascade for a serial through-flow, such that the gas stream fed to the drying sector (102) essentially completely corresponds to the gas stream discharged from the regeneration sector (103), optionally including the gas stream discharged from the cooling sector.

摘要翻译： 特别是用于干燥压缩气体的吸附干燥装置包括具有多个吸附管道（101）的吸附室（11），该吸附管道包含吸附材料（123），第一供给管线（106）和第一排出管线 109）设置在吸附室（11）的第一端（111），以及设置在吸附室（11）的第二端（112）的第二供给管线（108）和第二排出管线（107）。 吸附室（11）可相对于进料和排出管线（106,107,108,109）旋转，使得吸附管道可以在时间交替中流体连接，其中气体在干燥扇区（102）中干燥， ，并且在再生扇区（103）中再生吸附材料（123）。 第一供给管线（106）被构造成使得待干燥的气流可以作为全流进给到再生扇区（103）。 第二排出管路（107）与第二供给管线（108）连通，由此形成冷凝器的连接管路，在连接管路内设置增压装置（18） 从第二排出管线（107）流向第二供给管线（108）的气体的压力。 根据需要，冷却流可以在吸附室（11）的第一（111）或第二端（112）处分支，以冷却冷却扇区（119）内的吸附室（11）。 再生扇区（103）和干燥扇区（102）级联连接用于串联通流，使得供给干燥扇区（102）的气流基本上完全对应于从再生扇区排出的气流 103），可选地包括从冷却扇区排出的气流。

公开(公告)号：US08349054B2

公开(公告)日：2013-01-08

申请号：US12957468

申请日：2010-12-01

申请人： Andreas Fredenhagen ,  René Martin ,  Michael Feisthauer ,  Michael Rohdenburg

发明人： Andreas Fredenhagen ,  René Martin ,  Michael Feisthauer ,  Michael Rohdenburg

IPC分类号： B01D53/06 ,  B01D53/26

CPC分类号： B01D53/06 ,  B01D53/261 ,  B01D2257/80

摘要： An adsorption drying apparatus, in particular for drying a compressed gas, includes an adsorption chamber (11) having a plurality of adsorption conduits (101) containing an adsorption material (123), a first feeding line (106) and a first discharging line (109) disposed at a first end (111) of the adsorption chamber (11), and a second feeding line (108) and a second discharging line (107) disposed at a second end (112) of the adsorption chamber (11). The adsorption chamber (11) is rotatable with respect to the feeding and discharging lines (106, 107, 108, 109) so that the adsorption conduits may be fluidically connected in temporal alternation, wherein the gas is dried in a drying sector (102), and the adsorption material (123) is regenerated in the regeneration sector (103). The first feeding line (106) is configured such that the gas stream to be dried may be fed to the regeneration sector (103) as a full flow.

摘要翻译： 特别是用于干燥压缩气体的吸附干燥装置包括具有多个吸附管道（101）的吸附室（11），该吸附管道包含吸附材料（123），第一供给管线（106）和第一排出管线 109）设置在吸附室（11）的第一端（111），以及设置在吸附室（11）的第二端（112）的第二供给管线（108）和第二排出管线（107）。 吸附室（11）可相对于进料和排出管线（106,107,108,109）旋转，使得吸附管道可以在时间交替中流体连接，其中气体在干燥扇区（102）中干燥， ，并且在再生扇区（103）中再生吸附材料（123）。 第一供给管线（106）被构造成使得待干燥的气流可以作为全流进给到再生扇区（103）。

公开(公告)号：US07700348B2

公开(公告)日：2010-04-20

申请号：US10483379

申请日：2002-07-05

申请人： Jean René Martin ,  Michel Garrigues ,  Marlène Bras ,  Francois Bessueille ,  Eliane Souteyrand ,  Michel Cabrera ,  Jean-Pierre Cloarec ,  Jean-Paul Chauvet ,  Dorothée Chauvet, legal representative ,  Jean-Michel Chauvet, legal representative ,  Christophe Chauvet, legal representative

发明人： Jean René Martin ,  Michel Garrigues ,  Marlène Bras ,  Francois Bessueille ,  Eliane Souteyrand ,  Michel Cabrera ,  Jean-Pierre Cloarec ,  Jean-Paul Chauvet

IPC分类号： C12M1/34

CPC分类号： B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B82Y30/00 ,  G01N21/645 ,  G01N33/54353 ,  G01N33/54373 ,  G01N2021/6463

摘要： The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)λ/4 where k is a positive or zero integer and where λ designates a wavelength lying between a wavelength λ0 at which fluorescence is excited and a wavelength λ1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness mλ′/2 on a substrate and by making studs or wells of thickness (2k+1)λ/4 in said layer to form said sensitive sites.

摘要翻译： 本发明涉及一种生物芯片，其包括具有反射主表面的基底，并且其中主表面具有对具有光学厚度（2k + 1）λ/ 4的透明层对荧光检测敏感的局部位置，其中k为正或 零整数，其中λ表示位于激发荧光的波长λ0和发射荧光的波长λ1之间的波长。 生物芯片可以通过在衬底上沉积厚度为mλ'/ 2的透明层并且在所述层中制作厚度为（2k + 1）λ/ 4的螺柱或孔以形成所述敏感部位来制造。

公开(公告)号：US07561690B2

公开(公告)日：2009-07-14

申请号：US10053703

申请日：2002-01-24

申请人： Joël Maurin ,  René Martin ,  Jean-Yves Dujonc

发明人： Joël Maurin ,  René Martin ,  Jean-Yves Dujonc

IPC分类号： G06F7/04 ,  G06K9/00 ,  G06F11/30 ,  G06F12/14

CPC分类号： H04L63/0823 ,  H04L63/0442 ,  H04L67/02 ,  H04L69/329

摘要： A network communications method communicates a certificate from a client machine to a server machine through a security module. The protocol used between the client and server machines is HTTP or an equivalent protocol, and a security protocol such as SSL or an equivalent is implemented between the client machine and the security module. The steps of the method include inserting the certificate into a cookie header of a request in HTTP or an equivalent protocol, and then transmitting the request from the security module to the server machine.

摘要翻译： 网络通信方法通过安全模块将证书从客户机传送到服务器机器。 在客户机和服务器机器之间使用的协议是HTTP或等效的协议，并且在客户端计算机和安全模块之间实现诸如SSL或等效的安全协议。 该方法的步骤包括将证书插入到HTTP或等效协议中的请求的cookie头中，然后将请求从安全模块发送到服务器机器。