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公开(公告)号:US06500855B1
公开(公告)日:2002-12-31
申请号:US10033137
申请日:2002-01-02
IPC分类号: A61K31406
CPC分类号: C07D213/74 , C07D221/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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公开(公告)号:US06369227B1
公开(公告)日:2002-04-09
申请号:US09469830
申请日:1999-12-22
IPC分类号: C07D47102
CPC分类号: C07D213/74 , C07D221/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
摘要翻译: 本发明一般涉及胰蛋白酶样丝氨酸蛋白酶,特别是因子Xa或凝血酶的抑制剂,含有它们的药物组合物,以及使用它们作为抗凝血剂治疗和预防血栓栓塞障碍的方法。
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公开(公告)号:US06602871B2
公开(公告)日:2003-08-05
申请号:US10007195
申请日:2001-12-04
申请人: Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
发明人: Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
IPC分类号: C07D47104
CPC分类号: C07D213/74 , C07D221/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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公开(公告)号:US06403583B1
公开(公告)日:2002-06-11
申请号:US09469835
申请日:1999-12-22
申请人: Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
发明人: Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
IPC分类号: C07D40300
CPC分类号: C07D213/74 , C07D221/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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