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公开(公告)号:US07797040B2
公开(公告)日:2010-09-14
申请号:US11300965
申请日:2005-12-15
申请人: Bijan Pesaran , Richard A. Andersen
发明人: Bijan Pesaran , Richard A. Andersen
IPC分类号: A61B5/04
CPC分类号: A61B3/113 , A61B5/0482 , A61B5/0484 , A61B5/0496
摘要: Prosthetic devices, methods and systems are disclosed. Eye position and/or neural activity of a primate are recorded and combined. The combination signal is compared with a predetermined signal. The result of the comparison step is used to actuate the prosthetic device.
摘要翻译: 公开了假体装置,方法和系统。 记录和组合灵长类动物的眼部位置和/或神经活动。 将组合信号与预定信号进行比较。 比较步骤的结果用于致动假体装置。
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公开(公告)号:US06249691B1
公开(公告)日:2001-06-19
申请号:US09263973
申请日:1999-03-05
IPC分类号: A61B50478
CPC分类号: A61B5/04001 , A61B5/042
摘要: A chronic chamber microdrive (“CCMD”) for neural recording. In one implementation, a CCMD for neural recording from a target site of neural tissue exposed by an opening in a skull of a subject, includes: an outer cylinder, having a longitudinal axis, positioned within the opening and rotatable within the opening; an inner cylinder positioned within the outer cylinder, such that the longitudinal axis of the outer cylinder is within a circumference of the inner cylinder and the inner cylinder rotates within the rotatable outer cylinder; at least one fine leadscrew, positioned longitudinally in the inner cylinder; at least one electrode for neural recording, where at least one of said electrodes is coupled to a corresponding one of said fine leadscrews, where said electrodes are positioned horizontally by rotating the outer cylinder and separately rotating the inner cylinder, and where said electrodes are positioned vertically by rotating said fine leadscrews.
摘要翻译: 用于神经记录的慢性室微驱动(“CCMD”)。 在一个实施方案中,用于从受试者头骨中的开口暴露的神经组织的靶位点进行神经记录的CCMD包括:外筒,具有位于开口内且可在开口内旋转的纵轴; 位于所述外筒内的内筒,使得所述外筒的纵向轴线在所述内筒的圆周内,并且所述内筒在所述可旋转外筒内旋转; 至少一个细长的丝杠,纵向位于内筒中; 至少一个用于神经记录的电极,其中所述电极中的至少一个耦合到所述细丝杠的相应一个,其中所述电极通过旋转外筒并分开旋转内筒而水平定位,并且所述电极位于 通过旋转所述精细丝杠垂直。
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3.
公开(公告)号:US20100331976A1
公开(公告)日:2010-12-30
申请号:US12828728
申请日:2010-07-01
申请人: Bijan Pesaran , Richard A. Andersen
发明人: Bijan Pesaran , Richard A. Andersen
IPC分类号: A61F2/14
CPC分类号: A61B3/113 , A61B5/0482 , A61B5/0484 , A61B5/0496
摘要: Prosthetic devices, methods and systems are disclosed. Eye position and/or neural activity of a primate are recorded and combined. The combination signal is compared with a predetermined signal. The result of the comparison step is used to actuate the prosthetic device.
摘要翻译: 公开了假体装置,方法和系统。 记录和组合灵长类动物的眼部位置和/或神经活动。 将组合信号与预定信号进行比较。 比较步骤的结果用于致动假体装置。
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公开(公告)号:US08768449B2
公开(公告)日:2014-07-01
申请号:US12828728
申请日:2010-07-01
申请人: Bijan Pesaran , Richard A. Andersen
发明人: Bijan Pesaran , Richard A. Andersen
IPC分类号: A61B5/04
CPC分类号: A61B3/113 , A61B5/0482 , A61B5/0484 , A61B5/0496
摘要: Prosthetic devices, methods and systems are disclosed. Eye position and/or neural activity of a primate are recorded and combined. The combination signal is compared with a predetermined signal. The result of the comparison step is used to actuate the prosthetic device.
摘要翻译: 公开了假体装置,方法和系统。 记录和组合灵长类动物的眼部位置和/或神经活动。 将组合信号与预定信号进行比较。 比较步骤的结果用于致动假体装置。
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5.
公开(公告)号:US20080177196A1
公开(公告)日:2008-07-24
申请号:US11625230
申请日:2007-01-19
申请人: Joel W. Burdick , Jorge G. Cham , Zoran Nenadic , Edward A. Branchaud , Michael T. Wolf , Richard A. Andersen
发明人: Joel W. Burdick , Jorge G. Cham , Zoran Nenadic , Edward A. Branchaud , Michael T. Wolf , Richard A. Andersen
IPC分类号: A61B5/0476
CPC分类号: A61B5/04001 , A61B5/0478 , A61B5/061 , A61B5/4041 , A61B5/4893 , A61B5/7203 , A61B5/726 , A61B5/7264 , A61N1/08 , B33Y80/00 , G06K9/00536
摘要: The present invention relates to systems and methods for controlling neural prosthetic devices and electrophysiological recording equipment, and for using the same in clinical operation. Various embodiments of the invention are directed to an algorithm for autonomously isolating and maintaining neural action potential recordings. The algorithm may be used in connection with a neural interface microdrive capable of positioning electrodes to record signals from active neurons.
摘要翻译: 本发明涉及用于控制神经修复装置和电生理记录设备的系统和方法,并且用于临床操作。 本发明的各种实施例涉及用于自主隔离和维持神经动作电位记录的算法。 该算法可以与能够定位电极以记录来自活动神经元的信号的神经接口微驱动结合使用。
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公开(公告)号:US06952687B2
公开(公告)日:2005-10-04
申请号:US10193649
申请日:2002-07-10
申请人: Richard A. Andersen , Bijan Pesaran , Partha Mitra , Daniella Meeker , Krishna V. Shenoy , Shiyan Cao , Joel W. Burdick
发明人: Richard A. Andersen , Bijan Pesaran , Partha Mitra , Daniella Meeker , Krishna V. Shenoy , Shiyan Cao , Joel W. Burdick
CPC分类号: G06F3/015 , A61F2/68 , A61F2/72 , A61F2002/704 , A61F2002/705
摘要: A prosthetic system may use a decoder to predict an intended action, such as a reach, from processed signals generated from measured neural activity. The decoder may included a cognitive state machine, which transitions between cognitive states based on transition rules.
摘要翻译: 假体系统可以使用解码器从由测量的神经活动产生的经处理的信号中预测预期的作用,例如达到。 解码器可以包括认知状态机,其基于转换规则在认知状态之间转换。
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公开(公告)号:US08095210B2
公开(公告)日:2012-01-10
申请号:US11625230
申请日:2007-01-19
申请人: Joel W. Burdick , Jorge G. Cham , Zoran Nenadic , Edward A. Branchaud , Michael T. Wolf , Richard A. Andersen
发明人: Joel W. Burdick , Jorge G. Cham , Zoran Nenadic , Edward A. Branchaud , Michael T. Wolf , Richard A. Andersen
IPC分类号: A61B5/04
CPC分类号: A61B5/04001 , A61B5/0478 , A61B5/061 , A61B5/4041 , A61B5/4893 , A61B5/7203 , A61B5/726 , A61B5/7264 , A61N1/08 , B33Y80/00 , G06K9/00536
摘要: The present invention relates to systems and methods for controlling neural prosthetic devices and electrophysiological recording equipment, and for using the same in clinical operation. Various embodiments of the invention are directed to an algorithm for autonomously isolating and maintaining neural action potential recordings. The algorithm may be used in connection with a neural interface microdrive capable of positioning electrodes to record signals from active neurons.
摘要翻译: 本发明涉及用于控制神经修复装置和电生理记录设备的系统和方法,并且用于临床操作。 本发明的各种实施例涉及用于自主隔离和维持神经动作电位记录的算法。 该算法可以与能够定位电极以记录来自活动神经元的信号的神经接口微驱动结合使用。
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公开(公告)号:US07826894B2
公开(公告)日:2010-11-02
申请号:US11086534
申请日:2005-03-22
IPC分类号: A61B5/04
CPC分类号: G06F3/015 , A61F2/68 , A61F2002/704 , G06N3/061
摘要: In an embodiment, the invention relates to neural prosthetic devices in which control signals are based on the cognitive activity of the prosthetic user. The control signals may be used to control an array of external devices, such as prosthetics, computer systems, and speech synthesizers. Data obtained from monkeys' movement intentions were recorded, decoded with a computer algorithm, and used to position cursors on a computer screen. Not only the intended goals, but also the value of the reward the animals expected to receive at the end of each trial, were decoded from the recordings. The results indicate that brain activity related to cognitive variables can be a viable source of signals for the control of a cognitive-based neural prosthetic.
摘要翻译: 在一个实施例中,本发明涉及神经修复装置,其中控制信号基于假肢使用者的认知活动。 控制信号可用于控制诸如假肢,计算机系统和语音合成器之类的外部设备阵列。 记录从猴子运动意图获得的数据,用计算机算法解码,并用于将光标定位在计算机屏幕上。 不仅预期的目标,而且每个试验结束时期望收到的动物的奖励价值都从录音中解码出来。 结果表明,与认知变量相关的脑活动可以成为用于控制基于认知的神经假体的信号的可行来源。
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9.
公开(公告)号:US06920351B2
公开(公告)日:2005-07-19
申请号:US10304343
申请日:2002-11-25
申请人: Partha Mitra , Bijan Pesaran , Richard A. Andersen
发明人: Partha Mitra , Bijan Pesaran , Richard A. Andersen
CPC分类号: G06F3/015 , A61B5/04001 , A61B5/048 , A61B5/4064 , A61B5/726 , A61F2/72
摘要: In an embodiment, neural activity of a subject may be measured with an implant in the sensory motor cortex of the subject and used to predict an intended movement. The measured neural activity may be the local field potential (LFP) at an electrode or single unit (SU) activity. The spectral structure of the LFP and the SU activity may be estimated using spectral analysis techniques. The estimated LFP and SU responses may be used to predict and intended movement by the subject.
摘要翻译: 在一个实施例中,可以用对象的感觉运动皮层中的植入物测量受试者的神经活动,并用于预测预期的运动。 测量的神经活动可以是电极处的局部场电位(LFP)或单一单位(SU)活性。 可以使用光谱分析技术来估计LFP和SU活性的光谱结构。 估计的LFP和SU反应可以用于预测和预期的受试者的运动。
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10.
公开(公告)号:US06731964B2
公开(公告)日:2004-05-04
申请号:US10216668
申请日:2002-08-09
IPC分类号: A61B504
CPC分类号: A61F2/68 , A61F2/54 , A61F2/60 , A61F2/72 , A61F2002/704
摘要: The present invention provides a processed neural signal that encodes a reach plan, comprising the target location of the planned reach encoded relative to an eye-centered reference frame. The present invention also provides methods for generating and decoding the processed neural signal.
摘要翻译: 本发明提供了一种编码到达方案的经处理的神经信号,其包括相对于以眼睛为中心的参考帧编码的预定距离的目标位置。 本发明还提供了用于生成和解码经处理的神经信号的方法。
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