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1.发明授权Universal application server for providing applications on a variety of client devices in a client/server network 有权通用应用服务器，用于在客户端/服务器网络中的各种客户端设备上提供应用程序公开(公告)号：US06362836B1
公开(公告)日：2002-03-26
申请号：US09282765
申请日：1999-03-31
申请人： Andrew Shaw , Karl Richard Burgess , John Marcus Pullan , Peter Charles Cartwright , Roger David Binns , Andrew James Shire , Barry John Sturgeon , Christopher Scheybeler , Raymond Anderson
发明人： Andrew Shaw , Karl Richard Burgess , John Marcus Pullan , Peter Charles Cartwright , Roger David Binns , Andrew James Shire , Barry John Sturgeon , Christopher Scheybeler , Raymond Anderson
IPC分类号： G06F700
CPC分类号： H04L67/34 , H04L29/06 , H04L67/303 , H04L67/325 , H04L67/42 , H04L69/08 , H04L69/18 , H04L69/329
摘要： In a three tier client-server architecture, an universal application (UAP) server providing a middle or second tier between a third tier of application servers and a first tier of client devices to provide the controlled delivery of computer based application programs running on a set of application servers to a number of users using a wide variety of client devices without requiring the installation of software on, or changes to the application servers or application programs. The UAP server or application broker comprises a status manager engine, a session manager engine, a data store, a data store engine, a web server, and multiple instantiations of protocol engines design for a given application type and multiple instantiations of display engines for downloading to and operating on client devices. The UAP server provides: (1) means to support standard graphics based computer applications connected to clients of varying capability via a network of varying bandwidth and latency by automatically varying the type and number of graphic requests and their networking encoding to provide near optimum performance while maintaining the correct visual representation, (2) automatic construction of user worktops based on user data contained in a datastore, (3) loading balancing of application servers upon application launch and (4) resumable connections to client devices.
摘要翻译： 在三层客户机 - 服务器架构中，通用应用（UAP）服务器在第三层应用服务器和第一层客户端设备之间提供中间或第二层，以提供在集合上运行的基于计算机的应用程序的受控传递 的应用程序服务器，使用多种客户端设备的用户，而无需安装应用程序服务器或应用程序上的软件或更改。 UAP服务器或应用代理包括状态管理器引擎，会话管理器引擎，数据存储，数据存储引擎，web服务器以及用于给定应用类型的协议引擎设计的多个实例，以及用于下载的显示引擎的多个实例 在客户端设备上运行。 UAP服务器提供：（1）通过自动改变图形请求的类型和数量及其网络编码以提供接近最佳性能的方式，通过经由不同带宽和延迟的网络来支持连接到具有不同能力的客户端的基于标准图形的计算机应用， 维护正确的视觉表示，（2）基于数据存储中包含的用户数据自动构建用户工作台，（3）在应用程序启动时加载应用程序服务器的平衡，以及（4）到客户端设备的可恢复连接。
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2.发明授权公开(公告)号：US08993243B2
公开(公告)日：2015-03-31
申请号：US12987934
申请日：2011-01-10
申请人： David Beebe , Richard Burgess , Lindsay Strotman , Scott Berry
发明人： David Beebe , Richard Burgess , Lindsay Strotman , Scott Berry
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： G01N33/54326 , G01N33/543
摘要： Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.
摘要翻译： 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。
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公开(公告)号：US2205447A
公开(公告)日：1940-06-25
申请号：US22627638
申请日：1938-08-23
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公开(公告)号：US20110212509A1
公开(公告)日：2011-09-01
申请号：US13033351
申请日：2011-02-23
CPC分类号： B01D21/0009 , B01D2221/10 , B03C1/288 , B03C2201/18 , B03C2201/26 , C07K1/145 , C07K1/22 , C12N15/1006 , Y10T436/25375 , Y10T436/2575
摘要： A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein. An output zone receives a reagent therein. A force is movable between a first position adjacent the input zone and a second position adjacent the output zone. The force urges the fraction-bound solid phase substrate from the input zone, through the phase-gate zone and into the output zone.
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公开(公告)号：US20100154787A1
公开(公告)日：2010-06-24
申请号：US12600982
申请日：2008-05-21
摘要： A solar thermal unit adapted for fitting into one or more connectors designed for receiving one or more panes of glass (2), wherein said thermal solar unit includes a fluid circuit, a light-absorbing surface (3), and a housing for the light-absorbing surface (3) and fluid circuit, which housing extends to the. rear and sides of the light-absorbing surface.
摘要翻译： 一种太阳能热单元，其适于装配到一个或多个连接器中，所述连接器被设计用于容纳一个或多个玻璃板（2），其中所述热太阳能单元包括流体回路，光吸收表面（3）和用于所述光 - 吸收表面（3）和流体回路，该壳体延伸到。 光吸收表面的后部和侧面。
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6.发明申请Immunoaffinity chromatography using epitope tags to polyol-responsive monoclonal antibodies 有权使用表位标签进行多元醇反应性单克隆抗体的免疫亲和层析公开(公告)号：US20050272919A1
公开(公告)日：2005-12-08
申请号：US11148074
申请日：2005-06-08
申请人： Sarah Duellman , Nancy Thompson , Richard Burgess
发明人： Sarah Duellman , Nancy Thompson , Richard Burgess
CPC分类号： C07K7/06 , C07K1/22 , C07K7/08 , C07K16/18 , C07K16/40 , C07K2317/34 , Y10T436/13
摘要： Disclosed is a method of isolating, purifying, or concentrating a target compound. The method includes the steps of onjugating the target compound to an epitope for a polyol-responsive monoclonal antibody (PR-mAb) to yield a conjugate; and then contacting the conjugate to an immunoaffinity matrix comprising a PR-mAb specifically reactive with the PR-mAb epitope. Preferred epitopes for use in the method include amino acids of from 4 to about 30 amino acids, wherein the amino acid sequence comprises the sub-sequence D-X-S-R, (where X is any natural or unnatural amino acid), such as TKDPSRVG and TQDPSRVG. Additional epitopes for use in the method include SLAELLNGLGGS and PTSPSYSPTSPSYS. The method enables the rapid isolation of desired target compounds under gentle purification conditions.
摘要翻译： 公开了分离，纯化或浓缩目标化合物的方法。 该方法包括以下步骤：将目标化合物与多元醇应答单克隆抗体（PR-mAb）的表位接合以产生缀合物; 然后使缀合物与包含与PR-mAb表位特异性反应的PR-mAb的免疫亲和基质接触。 用于该方法的优选表位包括4至约30个氨基酸的氨基酸，其中氨基酸序列包含亚序列D-X-S-R（其中X是任何天然或非天然氨基酸），例如TKDPSRVG和TQDPSRVG。 用于该方法的其它表位包括SLAELLNGLGGS和PTSPSYSPTSPSYS。 该方法使得能够在温和的纯化条件下快速分离所需的目标化合物。
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7.发明授权Method of displaying an application on a variety of client devices in a client/server network 失效在客户机/服务器网络中的各种客户端设备上显示应用的方法
公开(公告)号：US6104392A
公开(公告)日：2000-08-15
申请号：US190757
申请日：1998-11-12
CPC分类号： H04L67/303 , H04L29/06 , H04L67/325 , H04L67/34 , H04L67/42 , H04L69/08 , H04L69/18 , H04L69/329
摘要： In a client-server architecture, an Adaptive Internet Protocol (AIP) system, comprised of a display engine operating on a server and a protocol engine operating on a server, provides means to support standard graphics based computer applications connected to clients of varying capability via a network of varying bandwidth and latency by automatically varying the type and number of graphic requests and their networking encoding to provide near optimum performance while maintaining the correct visual representation.
摘要翻译： 在客户机 - 服务器架构中，由在服务器上操作的显示引擎和在服务器上操作的协议引擎组成的自适应互联网协议（AIP）系统提供了支持基于标准图形的计算机应用的方法，所述计算机应用连接到具有不同能力的客户端 通过自动改变图形请求的类型和数量及其网络编码，提供不同带宽和延迟的网络，以提供接近最佳性能，同时保持正确的视觉表示。
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公开(公告)号：US08728410B2
公开(公告)日：2014-05-20
申请号：US13033351
申请日：2011-02-23
IPC分类号： B03C1/02
CPC分类号： B01D21/0009 , B01D2221/10 , B03C1/288 , B03C2201/18 , B03C2201/26 , C07K1/145 , C07K1/22 , C12N15/1006 , Y10T436/25375 , Y10T436/2575
摘要： A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein. An output zone receives a reagent therein. A force is movable between a first position adjacent the input zone and a second position adjacent the output zone. The force urges the fraction-bound solid phase substrate from the input zone, through the phase-gate zone and into the output zone.
摘要翻译： 提供了一种用于促进从生物样品中提取级分的装置和方法。 生物样品包括非期望的材料和分数结合的固相底物。 该装置包括用于在其中接收生物样本的输入区和用于在其中接收隔离缓冲器的相门区。 输出区在其中接收试剂。 力可在邻近输入区的第一位置与邻近输出区的第二位置之间移动。 力从输入区域通过相位闸区促进分数结合的固相基板进入输出区域。
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公开(公告)号：US08534312B2
公开(公告)日：2013-09-17
申请号：US12260532
申请日：2008-10-29
申请人： Richard Burgess , Ralph A. Diaz
发明人： Richard Burgess , Ralph A. Diaz
IPC分类号： F16K27/08
CPC分类号： F17C13/06 , F17C2201/058 , F17C2205/0165 , F17C2205/0308 , F17C2221/011 , F17C2221/014 , F17C2223/036 , F17C2250/043 , F17C2270/02 , F17C2270/05 , Y10T137/7043 , Y10T137/7062 , Y10T137/8326
摘要： A method and apparatus for providing a gas to or from a pressurized cylinder is described. The apparatus includes a gas delivery device housing that houses and protects a gas control device configured to deliver gas to a user or device, and may also be adapted to provide gas to the pressurized cylinder in a refilling process. The housing includes a surface free from unnecessary depressions and/or protrusions to facilitate cleanability and enhance safety during use. Adjustment indicators and status indication elements disposed in or on portions of the housing are configured to enhance readability and recognition, which facilitates safe and efficient operation of the device. Adjustable elements to control a flow metric from the gas control device are adapted to facilitate adjustment by a user with a large hand and/or a user suffering from some diminished physical capability.
摘要翻译： 描述了一种用于向加压筒提供气体的方法和装置。 该装置包括气体输送装置壳体，其容纳和保护构造成将气体输送到使用者或装置的气体控制装置，并且还可适于在再填充过程中向加压气瓶提供气体。 壳体包括没有不必要的凹陷和/或突起的表面，以便于清洁和提高使用时的安全性。 配置在外壳内部或外壳上的调节指示器和状态指示元件被配置为增强可读性和识别性，这有助于设备的安全和有效的操作。 用于控制来自气体控制装置的流量指标的可调节元件适于由用户用大手和/或患有某些减小的物理能力的使用者进行调整。
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公开(公告)号：US08459251B2
公开(公告)日：2013-06-11
申请号：US12600982
申请日：2008-05-21
IPC分类号： F24J2/46
摘要： A solar thermal unit adapted for fitting into one or more connectors designed for receiving one or more panes of glass (2), wherein said thermal solar unit includes a fluid circuit, a light-absorbing surface (3), and a housing for the light-absorbing surface (3) and fluid circuit, which housing extends to the rear and sides of the light-absorbing surface.
摘要翻译： 一种太阳能热单元，其适于装配到一个或多个连接器中，所述连接器被设计用于容纳一个或多个玻璃板（2），其中所述热太阳能单元包括流体回路，光吸收表面（3）和用于所述光 - 吸收表面（3）和流体回路，该壳体延伸到光吸收表面的后侧和侧面。
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