-
1.Compounds And Methods For Treating Candidiasis And Aspergillus Infections 有权
标题翻译: 化合物和治疗念珠菌和曲霉菌感染的方法公开(公告)号:US20130252964A1
公开(公告)日:2013-09-26
申请号:US13744517
申请日:2013-01-18
申请人: Richard W. Scott , Katie Freeman , Haizhong Tang , Gill Diamond
发明人: Richard W. Scott , Katie Freeman , Haizhong Tang , Gill Diamond
IPC分类号: C07D409/14 , C07D209/86 , C07D249/06 , C07D239/26 , C07C237/08 , C07C279/12 , C07C211/27 , C07C211/28 , C07C279/08 , C07C217/20 , C07D333/20 , C07D307/52 , C07D277/28 , C07D239/38 , C07D333/76 , C07D307/91 , C07D239/28
CPC分类号: A61K31/506 , A01N25/00 , A61K9/0053 , A61K9/06 , A61K31/381 , A61K31/404 , A61K31/4192 , A61K31/4436 , A61K31/496 , A61K31/505 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/20 , C07C237/08 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/12 , C07D209/86 , C07D239/26 , C07D239/28 , C07D239/38 , C07D249/06 , C07D277/28 , C07D307/52 , C07D307/91 , C07D333/20 , C07D333/76 , C07D409/14
摘要: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.
摘要翻译: 本公开内容提供了用于杀死或抑制念珠菌或曲霉菌种的生长或预防或治疗具有念珠菌病(口服和/或播撒)或曲霉属感染的哺乳动物的化合物或其药学上可接受的盐。
-
公开(公告)号:US20120039945A1
公开(公告)日:2012-02-16
申请号:US13177056
申请日:2011-07-06
申请人: Richard W. Scott , Gill Diamond
发明人: Richard W. Scott , Gill Diamond
IPC分类号: A61K31/167 , A61P31/04 , A61K31/197 , A61P37/02 , A61K31/166 , A61K31/505
CPC分类号: A61K31/166 , A61K31/167 , A61K31/197 , A61K31/505 , Y02A50/473
摘要: The present invention provides compounds and compositions thereof that modulate the immune system.
摘要翻译: 本发明提供调节免疫系统的化合物及其组合物。
-
公开(公告)号:US20100105703A1
公开(公告)日:2010-04-29
申请号:US12605584
申请日:2009-10-26
申请人: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号: A61K31/506 , C07D403/14 , A61P31/04
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
-
公开(公告)号:US20100081665A1
公开(公告)日:2010-04-01
申请号:US12510593
申请日:2009-07-28
申请人: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
发明人: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC分类号: A61K31/496 , C07C237/14 , A61K31/167 , C07D403/12 , A61K31/495 , C07D239/26 , A61P33/06
CPC分类号: C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
摘要: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要翻译: 本发明提供了三环化合物,芳酰胺化合物和其它化合物及其组合物,包含其的用于治疗疟疾的组合物,以及治疗疟疾的方法,包括向动物施用此类化合物。
-
公开(公告)号:US08975262B2
公开(公告)日:2015-03-10
申请号:US13563928
申请日:2012-08-01
申请人: William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
发明人: William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
IPC分类号: C07D403/14
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
-
公开(公告)号:US08802683B2
公开(公告)日:2014-08-12
申请号:US13471689
申请日:2012-05-15
申请人: Richard W. Scott , Bozena Korczak
发明人: Richard W. Scott , Bozena Korczak
IPC分类号: A01N43/54 , C07D239/42 , C07D401/04 , A61K31/506 , C07D239/26
CPC分类号: A61K31/167 , A61K9/006 , A61K31/4025 , A61K31/4178 , A61K31/505 , A61K31/506 , A61K38/18 , A61K38/1825 , A61K45/06 , C07D239/26
摘要: The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.
摘要翻译: 本发明提供用本文公开的一种或多种化合物或其药学上可接受的盐或包含其的组合物治疗和/或预防粘膜炎的方法。
-
公开(公告)号:US20130090345A1
公开(公告)日:2013-04-11
申请号:US13563928
申请日:2012-08-01
申请人: Willam F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
发明人: Willam F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
IPC分类号: C07D403/14
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
-
公开(公告)号:US20120295922A1
公开(公告)日:2012-11-22
申请号:US13471689
申请日:2012-05-15
申请人: Richard W. Scott , Bozena Korczak
发明人: Richard W. Scott , Bozena Korczak
IPC分类号: A61K31/443 , A61K31/505 , A61K31/444 , A61K31/4045 , A61P1/00 , A61K31/4468 , A61K31/4545 , A61K31/445 , A61K31/44 , A61P29/00 , A61K31/167 , A61K31/425
CPC分类号: A61K31/167 , A61K9/006 , A61K31/4025 , A61K31/4178 , A61K31/505 , A61K31/506 , A61K38/18 , A61K38/1825 , A61K45/06 , C07D239/26
摘要: The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.
摘要翻译: 本发明提供用本文公开的一种或多种化合物或其药学上可接受的盐或包含其的组合物治疗和/或预防粘膜炎的方法。
-
公开(公告)号:US20120258141A9
公开(公告)日:2012-10-11
申请号:US13177056
申请日:2011-07-06
申请人: Richard W. Scott , Gill Diamond
发明人: Richard W. Scott , Gill Diamond
IPC分类号: A61K31/167 , A61P31/04 , A61K31/197 , A61P37/02 , A61K31/166 , A61K31/505
CPC分类号: A61K31/166 , A61K31/167 , A61K31/197 , A61K31/505 , Y02A50/473
摘要: The present invention provides compounds and compositions thereof that modulate the immune system.
-
10.Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring 失效
标题翻译: 基因靶向的非人类哺乳动物与人类衰老早老素突变和代代后代公开(公告)号:US06284944B1
公开(公告)日:2001-09-04
申请号:US09041185
申请日:1998-03-10
IPC分类号: C12N500
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C12N2800/30 , G01N33/5082 , G01N33/6896
摘要: This invention discloses a gene-targeted non-human mammal and generational offspring with respect to the gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1); more specifically, a gene-targeted mouse with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed.
摘要翻译: 本发明公开了编码突变型早老素1基因(PS-1)的突变蛋白产物的基因的基因定向非人哺乳动物和代代子。 更具体地说,涉及编码PS-1突变型蛋白质产物的基因序列的基因靶向小鼠,该突变蛋白产物已被突变以含有人P264L突变。 还公开了使用这种哺乳动物筛选化合物的方法。
-
-
-
-
-
-
-
-
-