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    EPOTHILONE DERIVATIVES
    4.
    发明申请
    EPOTHILONE DERIVATIVES 有权

    公开(公告)号：US20070255055A1

    公开(公告)日：2007-11-01

    申请号：US11763636

    申请日：2007-06-15

    Applicant: Gregory Vite ,  Soong-Hoon Kim ,  Robert Borzilleri ,  James Johnson

    Inventor： Gregory Vite ,  Soong-Hoon Kim ,  Robert Borzilleri ,  James Johnson

    IPC: C07D225/02

    CPC classification number: C07D491/044 ,  C07D417/06 ,  C07D491/04 ,  C07D493/04

    Abstract: The present invention relates to compounds of the formula Q is selected from the group consisting of G is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo, W is O or NR15; X is O or H,H; Y is selected from the group consisting of O; H,OR16; OR17,OR17; NOR18; H,NOR19; H,NR20R21; H,H; or CHR22; OR17OR17 can be a cyclic ketal; Z1 and Z2 are selected from the group consisting of CH2, O, NR23, S, or SO2, wherein only one of Z and Z2 is a heteroatom; B1 and B2 are selected from the group consisting of OR24, or OCOR25, or O2CNR26R27; when B1 is H and Y is OH, H they can form a six-membered ring ketal or acetal; D is selected from the group consisting of NR28R29, NR30COR31 or saturated heterocycle; R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26, and R27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R1 and R2 are alkyl can be joined to form a cycloalkyl; R3 and R4 are alkyl can be joined to form a cycloalkyl; R9, R10, R16, R17, R24, R25, and R31 are selected from the group H, alkyl, or substituted alkyl; R8, R11, R12, R28, R30, R32, R33, and R30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo; R15, R23 and R29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R32C═O, R33SO2, hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds wherein W and X are both O; and R1, R2, R7, are H; and R3, R4, R6, are methyl; and R8, is H or methyl; and Z1, and Z2, are CH2; and G is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; and Q is as defined above are excluded.

    Pyrrolotriazine kinase inhibitors
    7.
    发明申请
    Pyrrolotriazine kinase inhibitors 有权
    吡咯并三嗪激酶抑制剂

    公开(公告)号：US20070123534A1

    公开(公告)日：2007-05-31

    申请号：US11605168

    申请日：2006-11-28

    Applicant: Zhen-Wei Cai ,  Kyoung Kim ,  Robert Borzilleri

    Inventor： Zhen-Wei Cai ,  Kyoung Kim ,  Robert Borzilleri

    IPC: A61K31/53 ,  C07D487/04

    CPC classification number: C07D487/04

    Abstract: In general, the instant invention comprises compounds having Formulae I and II: including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.

    Abstract translation: 通常，本发明包括具有式I和II的化合物：包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其它蛋白激酶介导的疾病。

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