公开(公告)号：US5211958A

公开(公告)日：1993-05-18

申请号：US877385

申请日：1992-04-29

申请人： Piet J. Akkerboom ,  Robert De Cocq ,  Maria Wegman

发明人： Piet J. Akkerboom ,  Robert De Cocq ,  Maria Wegman

IPC分类号： A61K9/20 ,  A61K31/65

CPC分类号： A61K31/65 ,  A61K9/0095 ,  A61K9/2054

摘要： A multi-purpose pharmaceutical tablet which can either be readily swallowed or dissolved in water to give a dispersion, comprising a tetracycline, microcrystalline cellulose or microfine cellulose, low substituted hydroxypropylcellulose and a thickening agent, preferably hydroxypropyl methylcellulose, and optionally other conventional adjuvants. The tablet may be easily swallowed as such, and when immersed in water, it affords a very fine dispersion within 30-60 seconds. The tablet may be prepared by direct compression, or by a wet granulation process in which a granulate is used which contains tetracycline and any substantial amount of a wet binding substance.

摘要翻译： 可以容易地吞咽或溶解在水中以产生分散体的多用途药物片剂，其包含四环素，微晶纤维素或微细纤维素，低取代的羟丙基纤维素和增稠剂，优选羟丙基甲基纤维素，以及任选的其它常规佐剂。 片剂本身容易吞咽，浸渍于水中时，可在30-60秒内提供极细的分散体。 片剂可以通过直接压片或通过湿法制粒方法制备，其中使用含有四环素和任何显着量的湿结合物质的颗粒。