公开(公告)号：US10271962B2

公开(公告)日：2019-04-30

申请号：US15810303

申请日：2017-11-13

申请人： Robert Heald ,  Richard Lim

发明人： Robert Heald ,  Richard Lim

IPC分类号： A61F2/46 ,  A61L27/54 ,  A61F2/30 ,  A61F2/28

摘要： The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US20180133027A1

公开(公告)日：2018-05-17

申请号：US15810303

申请日：2017-11-13

申请人： Robert Heald ,  Richard Lim

发明人： Robert Heald ,  Richard Lim

IPC分类号： A61F2/46 ,  A61L27/54

CPC分类号： A61F2/4601 ,  A61B17/80 ,  A61B17/8802 ,  A61F2/30723 ,  A61F2/4603 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61L27/54

摘要： The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US08653089B2

公开(公告)日：2014-02-18

申请号：US13369016

申请日：2012-02-08

申请人： Robert Heald ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Bohdan Waszkowycz

发明人： Robert Heald ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Bohdan Waszkowycz

IPC分类号： A61K31/52 ,  C07D473/00

CPC分类号： C07D473/34 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D473/16 ,  C07D473/32 ,  C07D473/40 ,  C07D487/04 ,  C07D495/04 ,  C07D498/06 ,  C07D513/04 ,  C07D519/00

摘要： Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式I化合物，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学障碍和癌症介导的病症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20120309765A1

公开(公告)日：2012-12-06

申请号：US13586147

申请日：2012-08-15

申请人： Stephen Price ,  Robert Heald ,  Wendy Lee ,  Mark E. Zak ,  Joanne Frances Mary Hewitt

发明人： Stephen Price ,  Robert Heald ,  Wendy Lee ,  Mark E. Zak ,  Joanne Frances Mary Hewitt

IPC分类号： A61K31/437 ,  A61P29/00 ,  A61P35/00 ,  A61K31/4985

CPC分类号： C07D471/04 ,  C07D235/00 ,  C07D401/04 ,  C07D487/04

摘要： The invention relates to a method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal comprising administering to said mammal a therapeutically effective amount of an imidazopyridine of formula I with anti-hyperproliferative activity.

摘要翻译： 本发明涉及抑制哺乳动物异常细胞生长或治疗过度增殖性疾病的方法，包括向所述哺乳动物施用治疗有效量的具有抗过度增殖活性的式I咪唑并吡啶。

公开(公告)号：US08293763B2

公开(公告)日：2012-10-23

申请号：US12808346

申请日：2008-12-18

申请人： Stephen Price ,  Robert Heald ,  Pascal Pierre Alexandre Savy

发明人： Stephen Price ,  Robert Heald ,  Pascal Pierre Alexandre Savy

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.(Formula I)

摘要翻译： 本发明涉及式I的咪唑并吡啶与抗癌和/或抗炎活性，更具体地涉及抑制MEK激酶活性的咪唑并吡啶类。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法（式I）

公开(公告)号：US08242104B2

公开(公告)日：2012-08-14

申请号：US12890812

申请日：2010-09-27

申请人： Nicole Blaquiere ,  Steven Do ,  Danette Dudley ,  Adrian Folkes ,  Robert Heald ,  Timothy Heffron ,  Mark Jones ,  Aleksandr Kolesnikov ,  Chudi Ndubaku ,  Alan G. Olivero ,  Stephen Price ,  Steven Staben ,  Lan Wang

发明人： Nicole Blaquiere ,  Steven Do ,  Danette Dudley ,  Adrian Folkes ,  Robert Heald ,  Timothy Heffron ,  Mark Jones ,  Aleksandr Kolesnikov ,  Chudi Ndubaku ,  Alan G. Olivero ,  Stephen Price ,  Steven Staben ,  Lan Wang

IPC分类号： A61K31/553 ,  C07D498/04 ,  C07D498/14

CPC分类号： C07D498/04 ,  A61K31/553 ,  A61K45/06 ,  C07D491/044 ,  C07D498/14 ,  C07D519/00

摘要： Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式I的苯并氧氮杂化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物及其药学上可接受的盐，其中：Z1是CR1或N; Z2为CR2或N; Z3为CR3或N; Z4是CR4或N; B是与苯并氧杂环环稠合的吡唑基，咪唑基或三唑基环，可用于抑制脂质激酶，包括p110α和PI3K的其他同种型，并用于治疗由脂质激酶介导的癌症等疾病。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20110142826A1

公开(公告)日：2011-06-16

申请号：US12809047

申请日：2008-12-19

申请人： Stephen Price ,  Robert Heald ,  Peter Hewitt

发明人： Stephen Price ,  Robert Heald ,  Peter Hewitt

IPC分类号： A61K39/395 ,  C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The invention relates to azaindolizines of formula I-a or I-b with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolizines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

摘要翻译： 本发明涉及具有抗癌和/或抗炎活性的式I-a或I-b的氮杂吲哚，更具体地涉及抑制MEK激酶活性的氮杂吲哚啉。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

公开(公告)号：US10709579B2

公开(公告)日：2020-07-14

申请号：US16142438

申请日：2018-09-26

申请人： Robert Heald ,  Richard Lim

发明人： Robert Heald ,  Richard Lim

IPC分类号： A61F2/46 ,  A61L27/54 ,  A61B17/88 ,  A61F2/30 ,  A61F2/28 ,  A61B17/00

摘要： The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US20190021878A1

公开(公告)日：2019-01-24

申请号：US16142438

申请日：2018-09-26

申请人： Robert Heald ,  Richard Lim

发明人： Robert Heald ,  Richard Lim

IPC分类号： A61F2/46 ,  A61L27/54 ,  A61F2/30 ,  A61F2/28

CPC分类号： A61F2/4601 ,  A61B17/8819 ,  A61B17/8822 ,  A61B2017/0046 ,  A61F2/30723 ,  A61F2/4603 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61L27/54

摘要： The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US20160016948A1

公开(公告)日：2016-01-21

申请号：US14745159

申请日：2015-06-19

申请人： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

发明人： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

IPC分类号： C07D471/04 ,  A61K45/06 ,  C07D498/10 ,  A61K31/5355 ,  A61K31/541 ,  C07D498/08 ,  A61K31/538 ,  C07D491/107 ,  A61K31/506 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10 ,  C07D519/00

摘要： This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

摘要翻译： 本发明涉及作为含有EGFR突变体的T790M抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗癌症的新化合物。