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公开(公告)号：US07045326B2
公开(公告)日：2006-05-16
申请号：US10046924
申请日：2002-01-14
CPC分类号： C12N9/1029 , A01K2217/05 , A61K38/00 , A61K2039/505 , C12Y203/0102 , C12Y203/01022
摘要： Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2α and MGAT1 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2α and MGAT1 activity; DGAT2α and MGAT1 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.
摘要翻译： 提供了编码具有甘油二酯酰基转移酶和/或单酰基甘油酰基转移酶活性的多肽产物的核酸组合物，以及由此编码的多肽产物，即哺乳动物DGAT2α和MGAT1多肽产物及其制备方法。 还提供了：用于调节DGAT2alpha和MGAT1活性的方法和组合物; DGAT2alpha和MGAT1转基因细胞，动物和植物，以及它们的制备方法; 以及制备甘油二酯，甘油二酯组合物，甘油三酯和甘油三酯组合物的方法以及通过这些方法制备的组合物。 主题方法和组合物可用于各种不同的应用，包括研究，医学，农业和工业应用。
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公开(公告)号：US06344548B1
公开(公告)日：2002-02-05
申请号：US09103754
申请日：1998-06-24
IPC分类号： C07H2104
CPC分类号： C12N9/1029 , A61K38/00 , C12N15/8247 , C12P7/6463
摘要： Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
摘要翻译： 提供了编码具有甘油二酯酰基转移酶活性的多肽产物的核酸组合物，以及由此编码的多肽产物及其生产方法。 主题多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用，以及治疗疗法和三酰基甘油的生产。
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公开(公告)号：US08435790B2
公开(公告)日：2013-05-07
申请号：US12508853
申请日：2009-07-24
申请人： Robert V. Farese, Jr. , Yi Guo , Tobias C. Walther , Peter Walter
发明人： Robert V. Farese, Jr. , Yi Guo , Tobias C. Walther , Peter Walter
IPC分类号： C12N15/01
CPC分类号： C12P7/649 , C12P7/6409 , C12P7/6436 , C12P7/6463 , Y02E50/13
摘要： The present invention is based on the discovery of a set of genes that are involved in lipid-droplet formation and regulation. Accordingly, the present invention provides methods of increasing or decreasing lipid concentrations in eukaryotic cells by decreasing or increasing expression of one of these genes. Increased lipid concentrations may be useful, for example, in the generation of biofuels. Decreased lipid concentration may be useful in the treatment of diseases characterized by excessive lipid storage. In addition, the invention provides methods of identifying markers of diseases characterized by excessive lipid storage.
摘要翻译： 本发明基于一组参与脂滴形成和调节的基因的发现。 因此，本发明提供通过减少或增加这些基因之一的表达来增加或减少真核细胞中的脂质浓度的方法。 增加的脂质浓度可能是有用的，例如生物燃料的产生。 降低的脂质浓度可用于治疗以过量脂质储存为特征的疾病。 此外，本发明提供鉴定以过量脂质储存为特征的疾病的标志物的方法。
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4.发明授权Genetically modified mouse lacking diacylglycerol acyltransferase-1 (DGAT-1) activity 有权遗传修饰的小鼠缺乏二酰基甘油酰基转移酶-1（DGAT-1）活性公开(公告)号：US07745691B2
公开(公告)日：2010-06-29
申请号：US11609810
申请日：2006-12-12
IPC分类号： A01K67/027 , A01K67/00 , G01N33/00
CPC分类号： G01N33/5088 , A61K38/00 , C12N9/1029 , C12N15/8247 , C12P7/64 , G01N2800/042
摘要： Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
摘要翻译： 提供了调节宿主中碳水化合物代谢的方法和组合物。 在主题方法中，二酰基甘油酰基转移酶（DGAT）活性（特别是DGAT1活性）被调节，例如降低或增强，以达到所需的胰岛素和/或瘦素敏感性，从而调节碳水化合物代谢，例如增加或降低血糖水平， 葡萄糖摄入细胞并同化成糖原。 还提供了用于实践本发明方法的药物组合物。 主题方法和组合物可用于各种应用，包括治疗与异常碳水化合物代谢相关的疾病如肥胖或糖尿病的宿主。
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公开(公告)号：US07238779B2
公开(公告)日：2007-07-03
申请号：US10779251
申请日：2004-02-12
CPC分类号： C12N9/1029
摘要： Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.
摘要翻译： 提供了编码新型ACAT蛋白质的核酸组合物，以及新型ACAT-2蛋白质（ACAT-2）。 还提供了产生目标核酸和蛋白质组合物的方法。 本发明的多肽和核酸组合物可用于各种应用，包括诊断和治疗剂筛选应用，以及用于与ACAT-2活性相关的疾病状况的治疗疗法，例如治疗胆结石。
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公开(公告)号：US20100021912A1
公开(公告)日：2010-01-28
申请号：US12508853
申请日：2009-07-24
申请人： Robert V. Farese, JR. , Yi Guo , Tobias C. Walther , Peter Walter
发明人： Robert V. Farese, JR. , Yi Guo , Tobias C. Walther , Peter Walter
IPC分类号： C12Q1/68 , C12N1/13 , C12N15/74 , C12N15/82 , C12N15/85 , C12N15/81 , C12N15/80 , C12P7/00 , C12P5/00 , C12N1/19 , C12N5/10
CPC分类号： C12P7/649 , C12P7/6409 , C12P7/6436 , C12P7/6463 , Y02E50/13
摘要： The present invention is based on the discovery of a set of genes that are involved in lipid-droplet formation and regulation. Accordingly, the present invention provides methods of increasing or decreasing lipid concentrations in eukaryotic cells by decreasing or increasing expression of one of these genes. Increased lipid concentrations may be useful, for example, in the generation of biofuels. Decreased lipid concentration may be useful in the treatment of diseases characterized by excessive lipid storage. In addition, the invention provides methods of identifying markers of diseases characterized by excessive lipid storage.
摘要翻译： 本发明基于一组参与脂滴形成和调节的基因的发现。 因此，本发明提供通过减少或增加这些基因之一的表达来增加或减少真核细胞中的脂质浓度的方法。 增加的脂质浓度可能是有用的，例如生物燃料的产生。 降低的脂质浓度可用于治疗以过量脂质储存为特征的疾病。 此外，本发明提供鉴定以过量脂质储存为特征的疾病的标志物的方法。
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公开(公告)号：US06869937B1
公开(公告)日：2005-03-22
申请号：US09605166
申请日：2000-06-27
CPC分类号： C12N9/1029
摘要： Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.
摘要翻译： 提供了编码新型ACAT蛋白质的核酸组合物，以及新型ACAT-2蛋白质（ACAT-2）。 还提供了产生目标核酸和蛋白质组合物的方法。 本发明的多肽和核酸组合物可用于各种应用，包括诊断和治疗剂筛选应用，以及用于与ACAT-2活性相关的疾病状况的治疗疗法，例如治疗胆结石。
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公开(公告)号：US06579974B1
公开(公告)日：2003-06-17
申请号：US09328857
申请日：1999-06-08
IPC分类号： C07H2102
CPC分类号： C12N9/1029
摘要： Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity.
摘要翻译： 提供了编码新型ACAT蛋白质的核酸组合物，以及新型ACAT-2蛋白质（ACAT-2）。 还提供了产生目标核酸和蛋白质组合物的方法。 本发明的多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用，以及用于与ACAT-2活性相关的疾病状况的治疗疗法。
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