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1.发明申请DEVICE AND METHOD FOR PRODUCING A REPLICATE OR DERIVATIVE FROM AN ARRAY OF MOLECULES, AND APPLICATIONS THEREOF 有权用于从分子阵列产生替代或衍生的装置和方法及其应用公开(公告)号：US20120015844A1
公开(公告)日：2012-01-19
申请号：US13224645
申请日：2011-09-02
CPC分类号： C12Q1/6837 , B01J19/0046 , C12Q2535/00 , C12Q2535/122 , C12Q2561/113
摘要： A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.
摘要翻译： 一种产生分子阵列的重复或衍生物的方法，该阵列具有分离的分离样品的空间排列，包括为每个样品创建至少一个空间有限的有效区域，其与另一个的有效区域分开 样品，具有绑定适配器或结合特性的表面，与有效区域相邻的载体。 在有效区域中通过扩增剂扩增分子，以产生样品的重复或衍生物。 样品的重复或衍生物通过结合适配器或结合特性结合到载体上，使得样品在载体上的重复或衍生物的空间排列对应于阵列中样品的空间排列 。 具有样本副本的载体从阵列中移除。
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2.发明申请Device and Method for Producing a Mixture of Two Phases that are Insoluble in Each Other 审中-公开用于生产彼此不溶的两相混合物的装置和方法公开(公告)号：US20090197977A1
公开(公告)日：2009-08-06
申请号：US12089035
申请日：2006-09-19
申请人： Stefan Haeberle , Jens Ducree , Roland Zengerle
发明人： Stefan Haeberle , Jens Ducree , Roland Zengerle
CPC分类号： B01F5/0471 , B01F3/04446 , B01F3/0807 , B01F13/0062 , B01F15/0201 , B01F15/0233
摘要： A device for producing a mixture of two phases that are insoluble in each other comprises a first fluid channel and a second fluid channel which lead into a contact region. Also, a third fluid channel is provided which leads into the contact region. The device comprises an imparter configured to impart a rotation on the fluid channels, a first phase being centrifugally supplied to the contact region through the first fluid channel, and a second phase, insoluble in the first phase, being supplied to the contact region through the second fluid channel, compressive and/or shearing forces in the contact region which are centrifugally/hydrodynamically induced by the rotation causing drops to break away in one of the phases supplied in order to produce the mixture of the first and second phases.
摘要翻译： 用于生产彼此不溶的两相混合物的装置包括第一流体通道和引入接触区域的第二流体通道。 此外，提供了引入接触区域的第三流体通道。 该装置包括致动器，其构造成在流体通道上施加旋转，第一相通过第一流体通道离心地供给到接触区域，并且不溶于第一相的第二相被提供给接触区域 第二流体通道，接触区域中的压缩和/或剪切力，其通过旋转离心/流体动力学引起，导致在所提供的相之一中的液滴脱离以产生第一和第二相的混合物。
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公开(公告)号：US20060147313A1
公开(公告)日：2006-07-06
申请号：US11353681
申请日：2006-02-14
CPC分类号： B01L3/0268 , B01L2300/0838 , B01L2300/123 , B01L2400/0481 , Y10S239/12
摘要： A microdosing apparatus comprises a fluid conduit having a flexible tube with a first end for connecting to a fluid reservoir and a second end where an outlet opening is located. An actuating device with a displacer with adjustable hub is provided, by which the volume of a portion of the flexible hub can be changed to thereby dispense liquid as free flying droplets or as free flying jet at the outlet opening by moving the displacer between a first end position and a second end position, whereby the tube is partly compressed in the first or the second end position. In other words, a microdosing apparatus comprises fluid conduit having a portion along which a cross section of the fluid conduit is variable by an actuating device to effect a change of the volume of the fluid conduit. A ratio of a fluidic impedance between the position of the actuating device and the outlet opening to a fluidic impedance between a first end of the fluid conduit and the position of the actuating device is variable by changing the position of the actuating device, so that a dosing volume dispensed at the outlet opening is variable thereby by at least 10%.
摘要翻译： 微量给药装置包括具有柔性管的流体导管，其具有用于连接到流体储存器的第一端和位于出口开口的第二端。 提供具有可调节轮毂的置换器的致动装置，通过该致动装置可以改变柔性轮毂的一部分的体积，从而以自由飞行液滴的方式分配液体，或者在出口处通过移动置换器在第一 末端位置和第二端部位置，由此管部分地在第一或第二端部位置被压缩。 换句话说，微量滴定装置包括流体导管，其具有一部分，流体导管的横截面沿着该部分可由致动装置变化，以实现流体导管体积的变化。 驱动装置的位置与出口之间的流体阻抗与流体导管的第一端与致动装置的位置之间的流体阻抗的比值可通过改变致动装置的位置而变化，从而使 在出口处分配的给药量可变至少10％。
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公开(公告)号：US07748962B2
公开(公告)日：2010-07-06
申请号：US11624493
申请日：2007-01-18
申请人： Stefan Haeberle , Jens Ducrée , Roland Zengerle , Norbert Schmitt
发明人： Stefan Haeberle , Jens Ducrée , Roland Zengerle , Norbert Schmitt
CPC分类号： F04B43/04 , F04B43/0054 , F04B43/043
摘要： A fluid handling apparatus includes a body, which comprises a fluid handling structure, and a flexible membrane attached to the body and formed to interact with a fluid in the fluid handling structure, wherein the membrane comprises a first actuation component. A second actuation component is provided, wherein the first and the second actuation component are formed such that the same attract or repel each other in a first positional relationship, in order to actuate the flexible membrane. A driving means is provided to move the body relative to the second actuation component, in order to bring the first and the second actuation component into the first and out of the first positional relationship.
摘要翻译： 流体处理设备包括主体，其包括流体处理结构，以及附接到主体并形成为与流体处理结构中的流体相互作用的柔性膜，其中所述膜包括第一致动部件。 提供了第二致动部件，其中第一致动部件和第二致动部件形成为使得其以第一位置关系相互吸引或排斥，以便致动柔性膜。 提供驱动装置以使主体相对于第二致动部件移动，以便使第一和第二致动部件进入第一和第二位置关系。
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5.发明授权公开(公告)号：US07479256B1
公开(公告)日：2009-01-20
申请号：US10069852
申请日：2000-04-10
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01L2400/0481 , C40B60/14 , G01N2035/1041
摘要： A device for device for applying a plurality of microdroplets onto a substrate has a plurality of nozzle orifices in a dosing head. In addition to walls for defining a liquid column of a medium to be dosed on each nozzle orifice, a pressure chamber is provided, which is adapted to be filled with a buffer medium and which is arranged in such a way that said buffer medium can simultaneously be used for applying a pressure to the liquid-column ends which are spaced apart from the nozzle orifices. A pressure generator is provided for applying a pressure to said buffer medium in such a way that a plurality of microdroplets will simultaneously be applied onto the substrate through said plurality of nozzle orifices. Finally, liquid reservoirs for the media to be dosed, which are in fluid communication with the liquid columns on the nozzle orifices are provided.
摘要翻译： 用于将多个微滴施加到基底上的装置的装置在计量头中具有多个喷嘴孔。 除了用于限定要在每个喷嘴孔口上定量的介质的液柱的壁之外，还提供了压力室，其适于填充有缓冲介质，并且其布置成使得所述缓冲介质可以同时 用于对与喷嘴孔间隔开的液柱端施加压力。 提供压力发生器，用于向所述缓冲介质施加压力，使得多个微滴同时通过所述多个喷嘴孔施加到基板上。 最后，提供了用于与喷嘴孔上的液体柱流体连通的介质的液体储存器。
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公开(公告)号：US09725758B2
公开(公告)日：2017-08-08
申请号：US13224645
申请日：2011-09-02
CPC分类号： C12Q1/6837 , B01J19/0046 , C12Q2535/00 , C12Q2535/122 , C12Q2561/113
摘要： A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.
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7.发明申请Apparatus and Method for Determining the Volume Fractions of the Phases in a Suspension 失效用于确定悬浮液中相的体积分数的装置和方法公开(公告)号：US20080280365A1
公开(公告)日：2008-11-13
申请号：US12067226
申请日：2006-10-05
申请人： Markus Grumann , Jens Ducree , Roland Zengerle , Lutz Riegger
发明人： Markus Grumann , Jens Ducree , Roland Zengerle , Lutz Riegger
CPC分类号： B01L3/502753 , B01L3/502746 , B01L3/502769 , B01L2200/0621 , B01L2200/0642 , B01L2200/0684 , B01L2300/028 , B01L2300/0803 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/088 , Y10T436/11 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： An apparatus for determining the volume fractions of the phases in a suspension includes a body, a channel structure, which is formed in the body, and an inlet area and a blind channel, which is fluidically connected to and capable of being filled via the same. Furthermore, a drive for imparting the body with rotation, so that phase separation of the suspension in the blind channel takes place, is provided. The blind channel includes such a channel cross-section and/or such wetting properties that, when filling same via the inlet area, higher capillary forces act in a first cross-sectional area than in a second cross-sectional area, so that at first the first cross-sectional area fills in the direction from the inlet area toward the blind end of the blind channel and then the second cross-sectional area fills in the direction from the blind end toward the inlet area.
摘要翻译： 用于确定悬架中的相的体积分数的装置包括主体，形成在主体中的通道结构以及流体连接到并且能够经由其填充的入口区域和盲通道 。 此外，提供了用于赋予身体旋转的驱动器，使得发生盲通道中的悬架的相分离。 盲通道包括这样的通道横截面和/或这种润湿性质，当通过入口区域填充相同的这种润湿性质时，较高的毛细作用力处于比在第二横截面积中的第一横截面积中，使得首先 第一横截面积从入口区域朝向盲通道的盲端的方向填充，然后第二横截面积从盲端朝向入口区域的方向填充。
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8.发明授权公开(公告)号：US07371330B2
公开(公告)日：2008-05-13
申请号：US11690731
申请日：2007-03-23
申请人： Jens Ducree , Roland Zengerle , Stefan Haeberle , Thilo Brenner
发明人： Jens Ducree , Roland Zengerle , Stefan Haeberle , Thilo Brenner
CPC分类号： B01D21/262 , B01D2221/10 , B01L3/502746 , B01L3/502753 , B01L2300/0803 , B01L2400/0409 , G01N15/042 , G01N15/05 , Y10T436/111666 , Y10T436/25375
摘要： A particle sedimentation apparatus includes a rotation body rotatable about a rotation axis and a separation chamber formed in the rotation body, to cause sedimentation of particle suspension in the separation chamber upon rotation of the rotation body. The particles accumulate in a radially outward region of the separation chamber. A flow-rate-determining inflow channel having azimuthal path length with an inflow channel inlet and an inflow channel outlet is formed in the rotation body, the inflow channel inlet being arranged radially further inwardly than the inflow channel outlet, the inflow channel outlet being fluidically connected to the separation chamber and formed to introduce particle suspension into the separation chamber upon rotation of the rotation body. Furthermore, an outflow channel is formed in the rotation body with an outflow channel inlet and an outflow channel outlet, to at least partially drain supernatant liquid formed by sedimentation from the separation chamber.
摘要翻译： 颗粒沉降装置包括旋转体，该旋转体可绕旋转轴线旋转，形成在旋转体中的分离室，在旋转体旋转时使颗粒悬浮液在分离室内沉降。 颗粒积聚在分离室的径向向外的区域中。 在旋转体中形成有具有入流通道入口和流入通道出口的方位通道长度的流量确定流入通道，流入通道入口比流入通道出口径向进一步向内设置，流入通道出口流动 连接到分离室并形成为当旋转体旋转时将颗粒悬浮液引入分离室。 此外，在旋转体中形成有流出通道入口和流出通道出口的流出通道，以至少部分地从分离室排出通过沉降形成的上清液。
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公开(公告)号：US20070189910A1
公开(公告)日：2007-08-16
申请号：US11624493
申请日：2007-01-18
申请人： Stefan Haeberle , Jens Ducree , Roland Zengerle , Norbert Schmitt
发明人： Stefan Haeberle , Jens Ducree , Roland Zengerle , Norbert Schmitt
IPC分类号： F04B17/00
CPC分类号： F04B43/04 , F04B43/0054 , F04B43/043
摘要： A fluid handling apparatus includes a body, which comprises a fluid handling structure, and a flexible membrane attached to the body and formed to interact with a fluid in the fluid handling structure, wherein the membrane comprises a first actuation component. A second actuation component is provided, wherein the first and the second actuation component are formed such that the same attract or repel each other in a first positional relationship, in order to actuate the flexible membrane. A driving means is provided to move the body relative to the second actuation component, in order to bring the first and the second actuation component into the first and out of the first positional relationship.
摘要翻译： 流体处理设备包括主体，其包括流体处理结构，以及附接到主体并形成为与流体处理结构中的流体相互作用的柔性膜，其中所述膜包括第一致动部件。 提供了第二致动部件，其中第一致动部件和第二致动部件形成为使得其以第一位置关系相互吸引或排斥，以便致动柔性膜。 提供驱动装置以使主体相对于第二致动部件移动，以便使第一和第二致动部件进入第一和第二位置关系。
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10.发明申请公开(公告)号：US20120314528A1
公开(公告)日：2012-12-13
申请号：US13469108
申请日：2012-05-11
申请人： Guenter ROTH , Oliver STROHMEIER , Roland ZENGERLE
发明人： Guenter ROTH , Oliver STROHMEIER , Roland ZENGERLE
IPC分类号： B01F15/04
CPC分类号： B01F13/0059 , B01F15/00253 , B01F15/00389 , B01F15/0233 , B01F15/0404 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L7/525 , B01L2200/0684 , B01L2200/0694 , B01L2200/141 , B01L2200/148 , B01L2300/0806 , B01L2300/0867 , B01L2400/0694 , B01L2400/088
摘要： A device for producing a dilution series from a solution to be diluted, which contains a substance to be diluted, and a dilution solution, includes a body of rotation, a drive configured to subject the body of rotation to rotations having different rotation protocols, and a controller configured to control the drive so as to subject the body of rotation to the different rotational frequencies. A first mixing chamber and a second mixing chamber are connected via a fluidic connection which enables producing, in the first mixing chamber, a first mixture having a first dilution ratio, transferring a partial volume of the first mixture into the second mixing chamber, and there producing a second mixture having a second dilution ratio.
摘要翻译： 用于从要稀释的待稀释溶液的稀释系列产生稀释系列的设备和稀释溶液包括旋转体，被配置为使转动体旋转具有不同旋转方案的旋转的驱动装置，以及 控制器，被配置为控制所述驱动器以使所述旋转体旋转到不同的旋转频率。 第一混合室和第二混合室通过流体连接连接，其能够在第一混合室中产生具有第一稀释比率的第一混合物，将第一混合物的部分体积转移到第二混合室中，并且在 产生具有第二稀释比的第二混合物。
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