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1.发明申请Systems and Methods for Identifying Cosmetic Agents for Skin Care Compositions 审中-公开用于鉴定护肤组合物的化妆品的系统和方法公开(公告)号：US20120283112A1
公开(公告)日：2012-11-08
申请号：US13402102
申请日：2012-02-22
申请人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B50/00
摘要： Provided are methods and systems for determining functional relationships between a cosmetic agent and a skin tissue condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a skin aging tissue condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
摘要翻译： 提供了用于确定化妆品和感兴趣的皮肤组织状况之间的功能关系的方法和系统。 还提供了用于鉴定影响皮肤老化组织状况的化妆品的方法和系统，以及用于制备化妆品组合物，个人护理产品或这两者的这些方法和系统鉴定的药剂的使用。
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2.发明申请Methods for identifying materials that can help regulate the condition of mammalian keratinous tissue 审中-公开识别可以帮助调节哺乳动物角质组织状况的材料的方法公开(公告)号：US20070196344A1
公开(公告)日：2007-08-23
申请号：US11655347
申请日：2007-01-19
申请人： Rosemarie Osborne , Lisa Mullins , Sara McPhall
发明人： Rosemarie Osborne , Lisa Mullins , Sara McPhall
摘要： Methods for identifying materials that can help regulate the condition of mammalian keratinous tissue (e.g., skin, hair, and/or nails), and the use of such materials selected by such methods (e.g., preparation of cosmetic compositions). The methods can also be used to generate data that can be used to support marketing claims and advertising claims, and to provide irritation and/or safety information. The methods can be used as an element of a method of doing business.
摘要翻译： 用于鉴定能够帮助调节哺乳动物角质组织（例如皮肤，毛发和/或指甲）的状况的材料的方法以及通过这些方法（例如，化妆品组合物的制备）选择的这些材料的使用。 这些方法还可用于生成可用于支持营销声明和广告声明的数据，并提供刺激和/或安全信息。 这些方法可以用作生意方式的一个元素。
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3.发明申请Transcriptional Profiling and Biomarker-Based Methods for Identifying and Evaluating Agents for Antioxidant Efficacy in Cosmetic Skin Care Formulations 审中-公开用于鉴定和评价化妆品护肤制剂中抗氧化功效的代谢分析和基于生物标志物的方法公开(公告)号：US20110262570A1
公开(公告)日：2011-10-27
申请号：US13022191
申请日：2011-02-07
申请人： Deborah Ruth Finlay , Robert Lloyd Binder , Michael Keith Robinson , Rosemarie Osborne , Lisa Ann Mullins
发明人： Deborah Ruth Finlay , Robert Lloyd Binder , Michael Keith Robinson , Rosemarie Osborne , Lisa Ann Mullins
IPC分类号： A61K8/97 , C07D339/04 , A61K8/36 , A61K8/49 , C12Q1/68 , A61Q19/00 , A61Q19/08 , C40B40/08 , C40B40/06 , C40B30/04 , C07C57/00 , A61K8/67
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , C12Q2600/16 , G01N33/5044 , G01N2333/90245 , G01N2500/04 , G01N2500/10
摘要： Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
摘要翻译： 与与年龄相关的对皮肤的氧化损伤相关的基因和基因产物的基因组，微阵列和生物标记面板以及用于鉴定和评价化妆品以预防，逆转或减少对皮肤的氧化损伤的基于转录谱的方法。 包含化妆品的化妆品和组合物，其能够诱导nrf2介导的抗氧化反应元件的活化以增加阶段2酶的表达，使用该试剂恢复对皮肤的最佳氧化还原状态的方法，以及用于鉴定和评估作用的化妆品的方法 通过nrf2介导的机制。
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公开(公告)号：US20100239510A1
公开(公告)日：2010-09-23
申请号：US12691471
申请日：2010-01-21
CPC分类号： A61Q19/00 , A61K8/4953 , A61K8/64 , A61K8/673 , A61K8/97
摘要： A skin-care composition may comprise a dill extract, a safe and effective amount of a peptide, a safe and effective amount of a hydrating skin active, and a dermatologically acceptable carrier. The skin-care composition may further comprise a safe and effective amount of an acute skin-care active. Further, a method of producing a chronic skin-firming benefit and, optionally, an acute skin-tightening sensation, said method comprising the step of topically applying to the skin of a mammal in need of such treatment, a safe and effective amount of the skin-care composition.
摘要翻译： 皮肤护理组合物可以包含莳萝提取物，安全有效量的肽，安全有效量的水合皮肤活性物质和皮肤病学可接受的载体。 护肤组合物还可以包含安全有效量的急性皮肤护理活性物质。 此外，产生慢性皮肤紧致效果和任选的急性皮肤紧张感的方法，所述方法包括局部施用于需要这种治疗的哺乳动物皮肤的步骤，安全有效量的 护肤组合物。
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公开(公告)号：US20160081902A1
公开(公告)日：2016-03-24
申请号：US14494742
申请日：2014-09-24
申请人： Rosemarie OSBORNE
发明人： Rosemarie OSBORNE
CPC分类号： A61K8/64 , A61K8/046 , A61K8/062 , A61K8/064 , A61K8/29 , A61K8/347 , A61K8/37 , A61K8/41 , A61K8/498 , A61K8/60 , A61K8/63 , A61K8/67 , A61K8/675 , A61K8/676 , A61K8/678 , A61K8/891 , A61K8/97 , A61K2800/10 , A61K2800/5922 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/02
摘要： Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
摘要翻译： 包含二肽的个人护理组合物和使用这些组合物治疗角质组织病症的方法。 所述二肽的C末端氨基酸是苏氨酸。 个人护理组合物可以局部施用，口服摄入，注射或用作组合治疗方案的一部分。
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公开(公告)号：US08871717B2
公开(公告)日：2014-10-28
申请号：US13082285
申请日：2011-04-07
申请人： Rosemarie Osborne
发明人： Rosemarie Osborne
摘要： Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
摘要翻译： 包含二肽的个人护理组合物和使用这些组合物治疗角质组织病症的方法。 所述二肽的C末端氨基酸是苏氨酸。 个人护理组合物可以局部施用，口服摄入，注射或用作组合治疗方案的一部分。
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公开(公告)号：US20110183914A1
公开(公告)日：2011-07-28
申请号：US13082285
申请日：2011-04-07
申请人： Rosemarie Osborne
发明人： Rosemarie Osborne
摘要： Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
摘要翻译： 包含二肽的个人护理组合物和使用这些组合物治疗角质组织病症的方法。 所述二肽的C末端氨基酸是苏氨酸。 个人护理组合物可以局部施用，口服摄入，注射或用作组合治疗方案的一部分。
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公开(公告)号：US20070020220A1
公开(公告)日：2007-01-25
申请号：US11411285
申请日：2006-04-26
申请人： Rosemarie Osborne
发明人： Rosemarie Osborne
摘要： Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
摘要翻译： 包含二肽的个人护理组合物和使用这些组合物治疗角质组织病症的方法。 所述二肽的C末端氨基酸是苏氨酸。 个人护理组合物可以局部施用，口服摄入，注射或用作组合治疗方案的一部分。
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公开(公告)号：US6020148A
公开(公告)日：2000-02-01
申请号：US877963
申请日：1997-06-18
IPC分类号： C07D209/48 , C07K14/00 , C07K16/00 , C07K16/44 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/94 , C12Q1/32
CPC分类号： C07D209/48 , C07K16/44 , G01N33/5014 , G01N33/5308 , G01N33/54326 , G01N33/94 , C12Q2304/24 , Y10S435/967 , Y10S436/815 , Y10S530/807
摘要： A technique for in vitro testing of ocular and dermal irritants is disclosed. The process involves the topical application of liquid, solid granular or gel-like materials (e.g. cosmetics) to a cell culture and then evaluating the cytotoxicity of the material. Cell cultures of human skin without a stratum corneum and having a histologic similarity to the eye are used. Irritation is evaluated by measuring cell viability using MTT assay (based on the reduction of a tetrazolium dye by functional mitochondria), or release of LDH or PGE.sub.2. A unique method of applying test materials which are not water soluble is described.
摘要翻译： 公开了用于眼部和皮肤刺激物体外测试的技术。 该方法涉及将液体，固体颗粒或凝胶状材料（例如化妆品）局部施用于细胞培养物，然后评估材料的细胞毒性。 使用没有角质层并且与眼睛具有组织学相似性的人皮肤的细胞培养物。 通过使用MTT测定（基于通过功能性线粒体的四唑鎓染料的还原）或LDH或PGE2的释放来测量细胞存活力来评估刺激。 描述了应用不溶于水的测试材料的独特方法。
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公开(公告)号：US20080095732A1
公开(公告)日：2008-04-24
申请号：US11893468
申请日：2007-08-16
申请人： Rosemarie Osborne
发明人： Rosemarie Osborne
CPC分类号： A61Q19/00 , A61K8/0229 , A61K8/046 , A61K8/40 , A61K8/64 , A61K8/675 , A61K38/08 , A61K2800/31
摘要： Personal care compositions comprising a dipeptide; one or more of the following: a pentapeptide, a second dipeptide, a vitamin B3 compound, a hexamindine compound, and/or a sugar amine; and a dermatologically acceptable carrier. Methods of using such compositions to treat the condition of keratinous tissue. In certain embodiments, the C terminal amino acid of said dipeptide is threonine.
摘要翻译： 包含二肽的个人护理组合物; 一种或多种以下物质：五肽，第二二肽，维生素B3化合物，己氮茚化合物和/或糖胺; 和皮肤病学上可接受的载体。 使用这些组合物治疗角质组织病症的方法。 在某些实施方案中，所述二肽的C末端氨基酸是苏氨酸。
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