公开(公告)号：US20110065085A1

公开(公告)日：2011-03-17

申请号：US12579308

申请日：2009-10-14

申请人： Roy Biran ,  Charles D. Claude ,  Robert L. Cleek ,  Paul D. Drumheller

发明人： Roy Biran ,  Charles D. Claude ,  Robert L. Cleek ,  Paul D. Drumheller

IPC分类号： C12Q1/527

CPC分类号： A61L33/0011 ,  A61L27/54 ,  A61L29/16 ,  A61L31/022 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L33/08 ,  A61L33/128 ,  A61L2300/236 ,  A61L2300/42 ,  C08L27/12

摘要： The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.

摘要翻译： 本发明涉及在操作后保留显着的生物活性的固定的生物活性物质。 本发明还包括包含通过至少一个肝素分子结合到底物上的肝素实体的医用底物，其中所述结合的肝素实体是肝素酶-1敏感的。

公开(公告)号：US20070027553A1

公开(公告)日：2007-02-01

申请号：US11193111

申请日：2005-07-29

申请人： Roy Biran ,  Edward Cully ,  Ted Farnsworth ,  Charles Flynn ,  Charles White

发明人： Roy Biran ,  Edward Cully ,  Ted Farnsworth ,  Charles Flynn ,  Charles White

IPC分类号： A61F2/02

CPC分类号： A61L31/148 ,  A61B17/07292 ,  A61L31/146 ,  A61L31/18 ,  Y10T442/608 ,  Y10T442/674 ,  Y10T442/677 ,  Y10T442/681 ,  Y10T442/682 ,  Y10T442/688

摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a very high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. In some embodiments, the web materials exhibit significant thrombogenic properties.

摘要翻译： 本发明涉及具有非常高的孔隙率的可植入的生物可吸收的非织造自粘性纤维网材料。 纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。 网页材料通常具有高度的阁楼。 网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。 在一些实施方案中，网状材料表现出显着的血栓形成性质。

公开(公告)号：US20070027554A1

公开(公告)日：2007-02-01

申请号：US11343509

申请日：2006-01-30

申请人： Roy Biran ,  Edward Cully ,  Ted Farnsworth ,  Charles Flynn ,  Philip Off ,  Charles White

发明人： Roy Biran ,  Edward Cully ,  Ted Farnsworth ,  Charles Flynn ,  Philip Off ,  Charles White

IPC分类号： A61F2/02

CPC分类号： A61L31/148 ,  A61B17/07292 ,  A61L31/146 ,  A61L31/18 ,  Y10T442/608 ,  Y10T442/674 ,  Y10T442/677 ,  Y10T442/681 ,  Y10T442/682 ,  Y10T442/688

摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. The web materials possess hemostatic properties.

摘要翻译： 本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。 纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。 网页材料通常具有高度的阁楼。 网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。 网状材料具有止血性能。

公开(公告)号：US20060140918A1

公开(公告)日：2006-06-29

申请号：US11360180

申请日：2006-02-23

申请人： Patrick Tresco ,  Roy Biran ,  Mark Noble

发明人： Patrick Tresco ,  Roy Biran ,  Mark Noble

IPC分类号： A61K35/12 ,  C12M3/00

CPC分类号： C12M25/14 ,  A61K35/12 ,  C12M21/08 ,  C12N5/0068 ,  C12N5/0618 ,  C12N2501/13 ,  C12N2502/08 ,  C12N2502/99 ,  C12N2533/10 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2535/10

摘要： The present invention relates to a device and corresponding methods for its use, in the propagation of tissue. The device comprises a bioartificial composite comprised of a substrate having at least one surface capable of the reception and growth promoting retention of a cellular preparation, and a first layer of adherent cells disposed on said surface. The first layer is prepared from the cellular preparation, and the cells comprising the first layer have cytoskeletal elements aligned uniformly, so that the bioartificial composite acts as a template to accept a second layer of cells upon the first layer, said second layer comprising an organized layer oriented in the direction of said first layer, wherein said substrate has at least one surface defined by a critical surface curvature and/or topography. The device may be implanted for the promotion of tissue regrowth, or may be used to develop tissue on an ex vivo basis, for implantation or for experimentation.

公开(公告)号：US07655584B2

公开(公告)日：2010-02-02

申请号：US11193111

申请日：2005-07-29

申请人： Roy Biran ,  Edward H. Cully ,  Ted R. Farnsworth ,  Charles Flynn ,  Charles F. White

发明人： Roy Biran ,  Edward H. Cully ,  Ted R. Farnsworth ,  Charles Flynn ,  Charles F. White

IPC分类号： A61B17/03 ,  A61F13/00 ,  D04H3/03 ,  D04H3/16

CPC分类号： A61L31/148 ,  A61B17/07292 ,  A61L31/146 ,  A61L31/18 ,  Y10T442/608 ,  Y10T442/674 ,  Y10T442/677 ,  Y10T442/681 ,  Y10T442/682 ,  Y10T442/688

摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a very high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. In some embodiments, the web materials exhibit significant thrombogenic properties.

摘要翻译： 本发明涉及具有非常高的孔隙率的可植入的生物可吸收的非织造自粘性纤维网材料。 纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。 网页材料通常具有高度的阁楼。 网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。 在一些实施方案中，网状材料表现出显着的血栓形成性质。

公开(公告)号：US07659219B2

公开(公告)日：2010-02-09

申请号：US11343509

申请日：2006-01-30

申请人： Roy Biran ,  Edward H. Cully ,  Ted R. Farnsworth ,  Charles Flynn ,  Philip P. Off ,  Charles F. White

发明人： Roy Biran ,  Edward H. Cully ,  Ted R. Farnsworth ,  Charles Flynn ,  Philip P. Off ,  Charles F. White

IPC分类号： A61B17/03 ,  A61F13/00 ,  D04H3/03 ,  D04H3/16 ,  B32B27/12

CPC分类号： A61L31/148 ,  A61B17/07292 ,  A61L31/146 ,  A61L31/18 ,  Y10T442/608 ,  Y10T442/674 ,  Y10T442/677 ,  Y10T442/681 ,  Y10T442/682 ,  Y10T442/688

摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. The web materials possess haemostatic properties.

摘要翻译： 本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。 纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。 网页材料通常具有高度的阁楼。 网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。 网状材料具有止血性。