公开(公告)号：US08150636B2

公开(公告)日：2012-04-03

申请号：US10498439

申请日：2002-12-06

Applicant: Rudi Labarbe ,  Roger Sewell ,  Sam Pumphrey

Inventor： Rudi Labarbe ,  Roger Sewell ,  Sam Pumphrey

IPC: G01N21/64 ,  G01N31/00

CPC classification number: G01N21/6408

Abstract: The invention provides a method and a measurement system for characterization of luminescence properties, the method comprises irradiating the luminescent material with a pulse of excitation light, providing a triggering signal correlated to the pulse of excitation light; detecting with a photodetector such as a photomultiplier tube (PMT) a plurality of photons emitted from the luminescent material as result of the pulse of excitation light, the photodetector providing an output signal upon the event of detection of a photon; determining for each detected photon a photon arrival time and providing an output suitable for inputting to an analysing module wherein an output comprises zero, one, or more photon arrival time for each excitation, receiving said outputs in an analysing module; and determining in the analysing module, characteristics properties of the luminescent material by performing a statistical analysis based on Bayesian inference.

Abstract translation: 本发明提供一种用于表征发光特性的方法和测量系统，该方法包括用激发光脉冲照射发光材料，提供与激发光脉冲相关的触发信号; 用光电倍增管（PMT）等光电检测器检测由激发光脉冲引起的从发光材料发射的多个光子，光检测器在检测光子时提供输出信号; 为每个检测到的光子确定光子到达时间并提供适于输入到分析模块的输出，其中输出包括用于每个激励的零个，一个或多个光子到达时间，在分析模块中接收所述输出; 并通过执行基于贝叶斯推理的统计分析，在分析模块中确定发光材料的特性。

公开(公告)号：US20090168960A1

公开(公告)日：2009-07-02

申请号：US12096990

申请日：2006-12-12

Applicant: Yves Jongen ,  Rudi Labarbe

Inventor： Yves Jongen ,  Rudi Labarbe

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61B6/0421 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1087

Abstract: Device for positioning a target volume (112) such, as a phantom or a patient in a radiation therapy apparatus, said apparatus directing a radiation beam (405) towards said target (112), characterized in that it comprises:—a target support (100) whereon the target is immobilized; a two dimensional radiation detector (103) fixed with fixations means (101,102, 104, 106 107; 301, 302, 304, 305, 306; 208, 209) in a known geometric relationship to said target support (100), said radiation detector (103) being capable of detecting the position of intersection of said radiation beam (105) with said detector (103); correcting means for correcting the relative position of said beam (105) and said target support 100), based on said detected intersection position.

Abstract translation: 用于在放射治疗设备中定位目标体积（112）的装置，例如幻影或患者，所述装置将辐射束（405）引向所述目标（112），其特征在于，其包括：目标支撑 100）目标是固定的; 以与已知几何关系的固定装置（101,102,104,106,107; 301,302,304,305,306,208,209）固定的二维辐射探测器（103），所述辐射探测器 （103）能够检测所述辐射束（105）与所述检测器（103）的交点的位置; 校正装置，用于基于所述检测到的交叉位置来校正所述光束（105）和所述目标支撑件100的相对位置。

公开(公告)号：US20110137159A1

公开(公告)日：2011-06-09

申请号：US12961172

申请日：2010-12-06

Applicant: Yves Jongen ,  Rudi Labarbe

Inventor： Yves Jongen ,  Rudi Labarbe

IPC: A61B5/05

CPC classification number: A61N5/1049 ,  A61B6/0421 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1087

Abstract: A device is provided for positioning a target volume, such as a phantom or a patient, in a radiation therapy apparatus. The apparatus directs a radiation beam towards the target. The apparatus can include a target support whereon the target is immobilized, a two dimensional radiation detector fixed with fixations means in a known geometric relationship to the target support, the radiation detector being capable of detecting the position of intersection of the radiation beam with the detector, and correcting means for correcting the relative position of the beam and the target support, based on the detected intersection position.

Abstract translation: 提供了用于在放射治疗装置中定位目标体积（例如体模或患者）的装置。 该装置将辐射束引向目标。 该装置可以包括目标固定在其上的目标支撑体，一个二维辐射探测器，固定有与目标支架已知几何关系的固定装置，该辐射探测器能够检测辐射束与探测器的相交位置 以及校正装置，用于基于检测到的交叉位置校正光束和目标支持体的相对位置。

公开(公告)号：US07860216B2

公开(公告)日：2010-12-28

申请号：US12096990

申请日：2006-12-12

Applicant: Yves Jongen ,  Rudi Labarbe

Inventor： Yves Jongen ,  Rudi Labarbe

IPC: G01K5/08

CPC classification number: A61N5/1049 ,  A61B6/0421 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1087

Abstract: Device for positioning a target volume (112) such, as a phantom or a patient in a radiation therapy apparatus, said apparatus directing a radiation beam (405) towards said target (112), characterized in that it comprises:—a target support (100) whereon the target is immobilized; a two dimensional radiation detector (103) fixed with fixations means (101, 102, 104, 106 107; 301, 302, 304, 305, 306; 208, 209) in a known geometric relationship to said target support (100), said radiation detector (103) being capable of detecting the position of intersection of said radiation beam (105) with said detector (103); correcting means for correcting the relative position of said beam (105) and said target support 100), based on said detected intersection position.

Abstract translation: 用于在放射治疗设备中定位目标体积（112）的装置，例如幻影或患者，所述装置将辐射束（405）引向所述目标（112），其特征在于，其包括：目标支撑 100）目标固定在哪里 以与所述目标支撑件（100）已知的几何关系固定的固定装置（101,102,104,106,107; 301,302,304,305,306,208,209）的二维辐射检测器（103），所述 辐射检测器（103）能够检测所述辐射束（105）与所述检测器（103）的交叉位置; 校正装置，用于基于所述检测到的交叉位置来校正所述光束（105）和所述目标支撑件100的相对位置。

公开(公告)号：US08351573B2

公开(公告)日：2013-01-08

申请号：US12961172

申请日：2010-12-06

Applicant: Yves Jongen ,  Rudi Labarbe

Inventor： Yves Jongen ,  Rudi Labarbe

IPC: G21K5/08

CPC classification number: A61N5/1049 ,  A61B6/0421 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1087

Abstract: A device is provided for positioning a target volume, such as a phantom or a patient, in a radiation therapy apparatus. The apparatus directs a radiation beam towards the target. The apparatus can include a target support whereon the target is immobilized, a two dimensional radiation detector fixed with fixations means in a known geometric relationship to the target support, the radiation detector being capable of detecting the position of intersection of the radiation beam with the detector, and correcting means for correcting the relative position of the beam and the target support, based on the detected intersection position.

Abstract translation: 提供了用于在放射治疗装置中定位目标体积（例如体模或患者）的装置。 该装置将辐射束引向目标。 该装置可以包括目标固定在其上的目标支撑体，一个二维辐射探测器，固定有与目标支架已知几何关系的固定装置，该辐射探测器能够检测辐射束与探测器的相交位置 以及校正装置，用于基于检测到的交叉位置校正光束和目标支持体的相对位置。

公开(公告)号：US06764215B2

公开(公告)日：2004-07-20

申请号：US10185966

申请日：2002-06-28

Applicant: Phil Meyler ,  Rudi Labarbe

Inventor： Phil Meyler ,  Rudi Labarbe

IPC: G01K1122

CPC classification number: G01N25/4813 ,  G01K17/00 ,  G01N21/1702 ,  G01N25/4826 ,  G01N25/4846

Abstract: The present invention relates to a method, a measuring cell and a system for measuring very small heat changes in a sample. The system comprises a measuring cell 16 for containing the sample during the measurement process, at least one electromagnetic radiation unit 14 for radiating one or several samples with modulated monochromatic or polychromatic radiation 46 inside said measuring cell 16. Said measuring cell 16 comprises at least one acoustic transducer 22 for generating a first output signal V(t) and at least one heat measuring device 24 for generating a second output signal T(t). Both signals are connectable to a combining unit 18 that generates an information signal by means of a reference signal f(t). Said information signal is connectable to a signal processing unit 20 for determining at least one relevant reaction parameter as a function of the measured heat change.

Abstract translation: 本发明涉及用于测量样品中非常小的热变化的方法，测量单元和系统。 该系统包括用于在测量过程中包含样品的测量单元16，至少一个电磁辐射单元14，用于在所述测量单元16内辐射具有调制单色或多色辐射46的一个或多个样本。所述测量单元16包括至少一个 用于产生第一输出信号V（t）的声换能器22和用于产生第二输出信号T（t）的至少一个热测量装置24。 两个信号可连接到通过参考信号f（t）产生信息信号的组合单元18。 所述信息信号可连接到信号处理单元20，用于根据所测量的热变化确定至少一个相关的反应参数。

公开(公告)号：US20090213371A1

公开(公告)日：2009-08-27

申请号：US12096908

申请日：2006-12-13

Applicant: Ian Goodyer ,  Tracy Ann Nutall ,  Rudi Labarbe ,  Nicholas Salvatore Arini ,  Andrew Seddon ,  Nick Stock ,  Gary Ross ,  Ralf Patz

Inventor： Ian Goodyer ,  Tracy Ann Nutall ,  Rudi Labarbe ,  Nicholas Salvatore Arini ,  Andrew Seddon ,  Nick Stock ,  Gary Ross ,  Ralf Patz

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/10 ,  G01J3/28 ,  G01N21/274 ,  G01N21/3563 ,  G01N21/359 ,  G01N2201/12707 ,  G01N2201/128 ,  G01N2201/129

Abstract: A spectrophotometer has a first photodetector (24) and a second photodetector (25) which is displaced spatially from the first photodetector in the direction of increasing wavelength in the spectrum. At any given time the second photodetector receives light at a wavelength which is substantially greater than that being received simultaneously by the first photodetector at that time. The first photodetector has first range of wavelengths over which it is operable and a first upper operating limit, and the second photodetector has a second range of wavelengths over which it is operable and a second upper operating limit, the second range overlapping the first range and the second upper operating limit being greater than the first upper operating limit. Thus the range of operation is extended, and data in two different ranges is processed simultaneously. The spectrophotometer comprises a housing (1) containing a light source (11), a monochromator (15, 16, 18) and the photodetectors, there being a fibre optic connected to a probe (2) for transmitting light from the light source to a sample to be analysed and receiving light from the sample. Optical components are mounted to a chassis (26) of the housing rigidly, the chassis being connected to the housing by shock absorbing mounts (28, 29). The light source is mounted to the housing by means of an adjuster (24) providing for adjustment laterally with respect to the optical axis of the light source.

Abstract translation: 分光光度计具有第一光电检测器（24）和第二光电检测器（25），该第二光电检测器（25）在光谱中沿着波长增加的方向从第一光电检测器空间位移。 在任何给定时间，第二光电探测器接收的光的波长远远大于在此时由第一光电检测器同时接收的波长。 第一光电探测器具有可操作的第一波长范围和第一上限工作极限，并且第二光电探测器具有可操作的第二波长范围和第二上限工作极限，第二范围与第一范围重叠， 第二上限运行极限大于第一上限运行极限。 因此，扩展了操作范围，同时处理两个不同范围的数据。 分光光度计包括容纳光源（11）的壳体（1），单色仪（15,16,18）和光电检测器，光纤连接到探头（2），用于将光从光源传输到 待分析样品并从样品中接收光。 光学元件刚性地安装到壳体的底盘（26）上，底盘通过减震座（28,29）连接到壳体。 光源通过调节器（24）安装到壳体，调节器（24）相对于光源的光轴横向调整。

公开(公告)号：US20060275847A1

公开(公告)日：2006-12-07

申请号：US10514138

申请日：2003-04-28

Applicant: Ian Goodyer ,  Rudi Labarbe ,  Dietrich Ruehlmann ,  Simon Stubbs

Inventor： Ian Goodyer ,  Rudi Labarbe ,  Dietrich Ruehlmann ,  Simon Stubbs

IPC: G01N33/554 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/26 ,  C12Q1/04

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/245

Abstract: An automated method for measuring the development of a biofilm, containing one or more fluorescent moieties, on a plurality of surfaces using a confocal imaging system including: a) a radiation source system for forming a beam of electromagnetic radiation including one or more wavelengths; b) an optical system for directing and focusing said beam onto one or more planes of the object; c) a detection system for detecting electromagnetic radiation emitted from the object and producing image data; and d) a scanning system for scanning the object in a plurality of planes with the electromagnetic radiation, the method comprising the steps of: i) growing said biofilm on said plurality of surfaces; ii) detecting the presence of said one or more fluorescent moieties within the biofilm by scanning the biofilm with electromagnetic radiation in a plurality of planes and collecting fluorescent emissions to produce a plurality of images; and iii) analysing said images by means of a data processing system under the control of computer software to determine the structure of the biofilm.

Abstract translation: 一种用于使用共焦成像系统在多个表面上测量含有一个或多个荧光部分的生物膜的开发的自动化方法，所述共聚焦成像系统包括：a）用于形成包括一个或多个波长的电磁辐射束的辐射源系统; b）用于将所述光束引导和聚焦到所述物体的一个或多个平面上的光学系统; c）用于检测从物体发射的电磁辐射并产生图像数据的检测系统; 以及d）用于利用所述电磁辐射在多个平面中扫描所述物体的扫描系统，所述方法包括以下步骤：i）在所述多个表面上生长所述生物膜; ii）通过在多个平面中用电磁辐射扫描生物膜并且收集荧光发射以产生多个图像来检测生物膜内所述一个或多个荧光部分的存在; 以及iii）在计算机软件的控制下通过数据处理系统分析所述图像，以确定生物膜的结构。

公开(公告)号：US20050256650A1

公开(公告)日：2005-11-17

申请号：US10498439

申请日：2002-12-06

Applicant: Rudi Labarbe ,  Roger Sewell ,  Sam Pumphrey

Inventor： Rudi Labarbe ,  Roger Sewell ,  Sam Pumphrey

IPC: G01N21/64 ,  G06F19/00 ,  G01N31/00 ,  G01N33/48 ,  G01N33/50

CPC classification number: G01N21/6408

Abstract: The invention provides a method and a measurement system for characterisation of luminescence properties, the method comprises irradiating the luminescent material with a pulse of excitation light, providing a triggering signal correlated to the pulse of excitation light; detecting with a photodetector such as a photomultiplier tube (PMT) a plurality of photons emitted from the luminescent material as result of the pulse of excitation light, the photodetector providing an output signal upon the event of detection of a photon; determining for each detected photon a photon arrival time and providing an output suitable for inputting to an analysing module wherein an output comprises zero, one, or more photon arrival time for each excitation, receiving said outputs in an analysing module; and determining. in the analysing module, characteristics properties of the luminescent material by performing a statistical analysis based on Bayesian inference.

Abstract translation: 本发明提供一种用于表征发光特性的方法和测量系统，该方法包括用激发光脉冲照射发光材料，提供与激发光脉冲相关的触发信号; 用光电倍增管（PMT）等光电检测器检测由激发光脉冲引起的从发光材料发射的多个光子，光检测器在检测光子时提供输出信号; 为每个检测到的光子确定光子到达时间并提供适于输入到分析模块的输出，其中输出包括用于每个激励的零个，一个或多个光子到达时间，在分析模块中接收所述输出; 并确定。 在分析模块中，通过基于贝叶斯推理进行统计分析，发光材料的特性。