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    Medical devices and materials containing isobutylene copolymer
    1.
    发明授权
    Medical devices and materials containing isobutylene copolymer 失效
    包含异丁烯共聚物的医疗器械和材料

    公开(公告)号：US08697119B2

    公开(公告)日：2014-04-15

    申请号：US10894394

    申请日：2004-07-19

    申请人： Robert E. Richard ,  Rudolf Faust

    发明人： Robert E. Richard ,  Rudolf Faust

    IPC分类号： A61K9/70

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L53/02

    摘要： The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.

    摘要翻译： 本发明涉及包含异丁烯共聚物的医疗装置。 本发明还涉及用于治疗剂递送的生物相容性共聚物材料，其包含负载治疗剂的异丁烯共聚物。 根据本发明的一个方面，提供了一种医疗装置，其包括：（a）基底和（b）至少一个包含共聚物的聚合物层，其设置在基底的全部或一部分上。 共聚物含有一个或多个聚合物链，其中异丁烯和升高的Tg单体（和任选地，其它单体）以随机，周期，统计或梯度分布引入。

    End-capped polymer chains and products thereof
    3.
    发明申请
    End-capped polymer chains and products thereof 审中-公开
    封端聚合物链及其制品

    公开(公告)号：US20110015349A1

    公开(公告)日：2011-01-20

    申请号：US12658115

    申请日：2010-02-02

    申请人： Rudolf Faust ,  Jae Cheol Cho

    发明人： Rudolf Faust ,  Jae Cheol Cho

    IPC分类号： C08F220/06 ,  C08F8/02 ,  C08F8/42

    CPC分类号： C08F297/026 ,  C08F8/00 ,  C08F110/10 ,  C08F295/00 ,  C08F297/00 ,  C08F297/02 ,  C08F10/10 ,  C08F4/00 ,  C08F2/38 ,  C08F2500/03 ,  C08F2500/01

    摘要： According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions. According to another aspect of the present invention, a novel polymer is provided that comprises a polymer chain, which chain further comprises the following: (a) a plurality of constitutional units that correspond to cationically polymerizable monomer species and (b) an end-cap comprising a group or a group, where R is a branched or unbranched alkyl group containing from 1 to 20 carbons and R1 is a branched, unbranched, or cyclic alkyl group or an aryl group, containing from 1 to 20 carbons. Other aspects of the present invention relate to novel copolymers that comprise: (a) a first polymer block that comprises a plurality of constitutional units that correspond to isobutylene; and (b) a second polymer block that comprises a plurality of constitutional units that correspond to hydroxyethyl methacrylate.

    摘要翻译： 根据本发明的一个方面，提供了一种方法，其中双二苯基乙烯化合物与含有碳阳离子末端链的聚合物反应，从而提供1,1-二亚苯基端官能化链。 随后，使烷基化剂与1,1-二亚苯基末端官能化链反应，从而提供烷基化的1,1-二亚苯基端官能化链。 在一些实施方案中，该方法还包括（a）任选地将1,1-二苯基有机锂化合物与烷基化的1,1-二亚苯基端官能化聚合物组合，然后（b）使有机锂化合物与烷基化的1,1-二亚苯基末端 官能化聚合物。 这提供了阴离子封端的聚合物，其可以用于例如随后的阴离子聚合和偶联反应。 根据本发明的另一方面，提供了一种包含聚合物链的新型聚合物，该链还包含以下物质：（a）多个与阳离子可聚合单体物质相对应的结构单元和（b）端帽 包括基团或基团，其中R是含有1至20个碳的支链或非支链烷基，R 1是含有1至20个碳的支链，非支链或环状烷基或芳基。 本发明的其它方面涉及包含以下的新型共聚物：（a）包含对应于异丁烯的多个结构单元的第一聚合物嵌段; 和（b）包含对应于甲基丙烯酸羟乙酯的多个结构单元的第二聚合物嵌段。

    Coupling of polymers made by cationic polymerization
    7.
    发明授权
    Coupling of polymers made by cationic polymerization 失效
    通过阳离子聚合制成的聚合物的偶联

    公开(公告)号：US5690861A

    公开(公告)日：1997-11-25

    申请号：US398953

    申请日：1995-03-02

    申请人： Rudolf Faust

    发明人： Rudolf Faust

    IPC分类号： C08F297/00 ,  C08F297/08 ,  C08F10/10 ,  C08F293/00

    CPC分类号： C08F297/08 ,  C08F297/00

    摘要： A method for coupling a cationic polymer includes forming a reaction mixture of a cationic polymer and a bis(diphenylethylene). The reaction mixture is exposed to a temperature which causes the bis(diphenylethylene) to react with the cationic polymer, thereby coupling to cationic polymer. In another embodiment, the method includes forming a reaction mixture of an oxo-acid and a isopropenyl polyisobutylene. The reaction mixture is exposed to a temperature below about -30.degree. C., whereby the oxo-acid reacts with isopropenyl polyisobutylene, thereby coupling the polymer.

    摘要翻译： 用于偶联阳离子聚合物的方法包括形成阳离子聚合物和双（二苯基乙烯）的反应混合物。 将反应混合物暴露于导致双（二苯基乙烯）与阳离子聚合物反应的温度，从而偶联至阳离子聚合物。 在另一个实施方案中，该方法包括形成含氧酸和异丙烯基聚异丁烯的反应混合物。 将反应混合物暴露于低于约-30℃的温度，由此含氧酸与异丙烯基聚异丁烯反应，从而偶联聚合物。

    Capping of living polymers
    8.
    发明授权
    Capping of living polymers 失效
    活性聚合物的封盖

    公开(公告)号：US5677386A

    公开(公告)日：1997-10-14

    申请号：US410525

    申请日：1995-03-24

    申请人： Rudolf Faust

    发明人： Rudolf Faust

    IPC分类号： C08F8/00 ,  C08F10/10 ,  C08F110/10

    CPC分类号： C08F8/02 ,  C08F10/10 ,  C08F2810/40 ,  Y10S525/918

    摘要： The present invention provides a process for the capping of a living polymer with a substituted or unsubstituted diphenyl alkylene. Diphenyl alkylene is defined to also include substituted or unsubstituted .alpha.-methoxystyrene, trans-stilbene, 1-isopropenylnapthalene and 2,4-dimethyl-.alpha.-methylstyrene.

    摘要翻译： 本发明提供了用取代或未取代的二苯基亚烷基封端活性聚合物的方法。 二苯基亚烷基也包括取代或未取代的α-甲氧基苯乙烯，反式二苯乙烯，1-异丙烯基萘和2,4-二甲基-α-甲基苯乙烯。

    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
    10.
    发明授权
    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
    具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置

    公开(公告)号：US08535702B2

    公开(公告)日：2013-09-17

    申请号：US11048616

    申请日：2005-02-01

    申请人： Robert E. Richard ,  Frederick H. Strickler ,  Marlene C. Schwarz ,  Rudolf Faust ,  Shrirang V. Ranade ,  Michael N. Helmus

    发明人： Robert E. Richard ,  Frederick H. Strickler ,  Marlene C. Schwarz ,  Rudolf Faust ,  Shrirang V. Ranade ,  Michael N. Helmus

    IPC分类号： A61F2/00

    CPC分类号： A61L31/129 ,  A61L27/48 ,  A61N1/05

    摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    摘要翻译： 本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。 在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物 区域在体内成为纳米孔聚合物区域。 本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。 这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。 在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗 在植入或插入医疗装置时在体内释放的药剂。