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    Reagent for digestion of hemoglobin
    1.
    发明授权
    Reagent for digestion of hemoglobin 有权
    用于消化血红蛋白的试剂

    公开(公告)号：US07807401B2

    公开(公告)日：2010-10-05

    申请号：US12330725

    申请日：2008-12-09

    Applicant: Uwe Kobold ,  Thomas Duelffer ,  Rupert Herrmann ,  Bernd Vogt ,  Herbert von der Eltz

    Inventor： Uwe Kobold ,  Thomas Duelffer ,  Rupert Herrmann ,  Bernd Vogt ,  Herbert von der Eltz

    IPC: C12Q1/37

    CPC classification number: G01N33/723 ,  G01N2333/95

    Abstract: The present invention relates to a reagent for digestion of hemoglobin comprising a buffer, pepsin and a 1,3-dialkyl-imidazolium salt. It also discloses to the use of this reagent in a method for digesting hemoglobin, in a method for detecting HbA1c, and to a sampling tube for collection of a whole blood sample comprising said reagent for digesting hemoglobin.

    Abstract translation: 本发明涉及一种用于消化血红蛋白的试剂，其包含缓冲液，胃蛋白酶和1,3-二烷基 - 咪唑鎓盐。 还公开了在用于消化血红蛋白的方法中使用该试剂，在检测HbA1c的方法中，以及用于收集包含用于消化血红蛋白的所述试剂的全血样品的采样管。

    Pentacyclic compounds and their use as absorption or fluorescent dyes
    5.
    发明授权
    Pentacyclic compounds and their use as absorption or fluorescent dyes 失效
    五环化合物及其作为吸收或荧光染料的用途

    公开(公告)号：US5750409A

    公开(公告)日：1998-05-12

    申请号：US454440

    申请日：1995-05-30

    Applicant: Rupert Herrmann ,  Hans-Peter Josel ,  Karl-Heinz Drexhage ,  Jutta Arden-Jacob

    Inventor： Rupert Herrmann ,  Hans-Peter Josel ,  Karl-Heinz Drexhage ,  Jutta Arden-Jacob

    IPC: C09B11/24 ,  C09B11/28 ,  G01N33/58 ,  G01N33/557 ,  C07D221/18 ,  C07D491/00 ,  G01N33/536

    CPC classification number: G01N33/582 ,  C09B11/24 ,  C09B11/28 ,  Y10S436/80

    Abstract: Pentacyclic derivatives having the general formulae (Ia), (Ib) and (Ic) ##STR1## denote: hydrogen, alkyl with 1 to 20 carbon atoms polyoxyhydrocarbyl, phenyl, phenylalkyl with 1 to 3 carbon atoms in the alkyl chain, wherein the alkyl residues or/and phenyl residues can be substituted by one or several hydroxy, halogen, sulfo, carboxy or alkoxycarbonyl groups in which alkoxy can have 1 to 4 carbon atoms; R.sup.7 denotes an alkyl group with 1 to 7 carbon atoms, substituted by at least one halogen, or denotes a carboxyalkyl group or a phenyl group which is substituted by a carboxy or alkoxycarbonyl group located at the o-position relative to the carbon atom bound to the pentacyclic ring system and by at least one halogen, wherein alkoxy can have 1 to 4 carbon atoms, or a carboxymethylene-oxy-alkyloxy group; the residues R.sup.14 and R.sup.15 as well as the positions on the rings in the formulae that are not marked by specific symbols denote any desired substituents which may optionally be linked together; the two bonds marked by a broken line mean that the two carbon atoms which are joined by the bond marked by a broken line can be linked together by a single or double bond; and X.sup.- is a counterion; as well as their derivatives activated at least at one of the residues R.sup.1, R.sup.7 or/and R.sup.13. The compounds can be used as absorption or fluorescent dyes, in particular as markers for hapten/antibody/protein conjugates, as laser dyes and as an absorption medium for solar collectors.

    Abstract translation: （Ⅰa）（Ⅰa）（Ⅰa）表示氢，碳原子数1〜20的烷基，聚氧烃基，苯基， 在烷基链中具有1至3个碳原子的苯基烷基，其中烷基残基或/和苯基残基可以被一个或多个羟基，卤素，磺基，羧基或烷氧基羰基取代，其中烷氧基可以具有1至4个碳原子; R7表示具有1至7个碳原子的烷基，被至少一个卤素取代，或表示羧基烷基或被位于相对于与碳原子结合的碳原子的o位置的羧基或烷氧基羰基取代的苯基 五环环系和至少一个卤素，其中烷氧基可以具有1至4个碳原子，或羧基亚甲氧基 - 烷氧基; 残基R14和R15以及未被特定符号标记的式中的环上的位置表示可任选地连接在一起的任何所需取代基; 由虚线标记的两个键意味着通过用虚线标记的键连接的两个碳原子可以通过单键或双键连接在一起; X-是抗衡离子; 以及至少在残基R1，R7或/和R13之一激活的它们的衍生物。 该化合物可用作吸收或荧光染料，特别是作为半抗原/抗体/蛋白质缀合物的标记物，作为激光染料和作为太阳能收集器的吸收介质。

    Resorufin derivatives
    6.
    发明授权
    Resorufin derivatives 失效
    Resorufin衍生物

    公开(公告)号：US5304645A

    公开(公告)日：1994-04-19

    申请号：US758288

    申请日：1991-03-28

    Applicant: Christian Klein ,  Hans-Georg Batz ,  Rupert Herrmann

    Inventor： Christian Klein ,  Hans-Georg Batz ,  Rupert Herrmann

    IPC: C07C237/22 ,  C07C279/10 ,  C07D265/38 ,  C07D413/12 ,  C07J71/00 ,  C07K1/113 ,  C07K14/00 ,  C07K14/42 ,  C07K14/575 ,  C07K14/705 ,  C07K16/00 ,  C07K19/00 ,  C09B19/00 ,  G01N33/533 ,  A61K31/435 ,  A61K31/495

    CPC classification number: G01N33/533 ,  C07D265/38 ,  Y10S436/80 ,  Y10S530/802

    Abstract: The present invention provides resorufin derivatives of the general formulae: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which can be the same or different, are hydrogen, halogen, carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups or lower alkyl or lower alkoxy radicals, which can be substituted by carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups, and wherein R.sup.4 and R.sup.5 can together also represent an anellated aromatic residue, Z is a bridge member, A is the residue of a ligand and n is a whole number of from 1 to 200.The present invention also provides processes for the preparation of these resorufin derivatives, as well as intermediates for the preparation thereof.

    Abstract translation: 本发明提供通式为：其中R 1，R 2，R 3，R 4和R 5可以相同或不同的氢，卤素，羧基，甲酰胺基，低级烷氧基羰基，氰基或硝基的通式 低级烷基或低级烷氧基，其可以被羧基，甲酰氨基，低级烷氧基羰基，氰基或硝基取代，并且其中R 4和R 5一起也可以代表苯并芳族残基，Z是桥连，A是 配体，n是1至200的整数。本发明还提供制备这些稀释剂衍生物的方法，以及制备它们的中间体。

    Use of aniline derivates as coupling components in oxidative color formation reactions
    8.
    发明授权
    Use of aniline derivates as coupling components in oxidative color formation reactions 失效
    在氧化色彩形成反应中苯胺衍生物作为偶联组分的使用

    公开(公告)号：US4845030A

    公开(公告)日：1989-07-04

    申请号：US122600

    申请日：1987-11-20

    Applicant: Hans-Georg Batz ,  Rupert Herrmann ,  Fritz Topfmeier ,  Helmut Schlumberger

    Inventor： Hans-Georg Batz ,  Rupert Herrmann ,  Fritz Topfmeier ,  Helmut Schlumberger

    IPC: G01N33/52 ,  C09B57/00 ,  C12Q1/28 ,  G01N21/77 ,  G01N21/78 ,  G01N33/50

    CPC classification number: C12Q1/28 ,  C12Q2326/00 ,  Y10T436/144444 ,  Y10T436/206664

    Abstract: The present invention is concerned with the use of aniline derivatives of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a --(CH.sub.2).sub.n --X radical, in which n is a whole number of from 1 to 3, X is H, OH, NH.sub.2, CH.sub.3 CONH, CH.sub.3 SO.sub.2 NH, COOH, SO.sub.3 H or --ArSO.sub.3 H, Ar being an optionally substituted arylene radical, m is a whole number of from 2 to 4, R.sup.3 is a hydrogen atom, an alkyl radical containing up to 3 carbon atoms, OCH.sub.3, CH.sub.3 CONH, COOH or SO.sub.3 H and R.sup.4 is a hydrogen, chlorine or bromine atom or a carboxylic acid or sulphonic acid group, as coupling components in oxidative color formation reactions.The present invention also provides an agent for the analytical determination of oxidizing substances by oxidative color coupling which, as coupling component, contains at least one compound of general formula (I).

    Abstract translation: 本发明涉及以下通式的苯胺衍生物的用途：其中R 1为氢原子或 - （CH 2）n X基团，其中n为1至3的整数， X是H，OH，NH 2，CH 3 CONH，CH 3 SO 2 NH，COOH，SO 3 H或-ArSO 3 H，Ar是任选取代的亚芳基，m是整数2至4，R 3是氢原子， 3个碳原子，OCH 3，CH 3 CONH，COOH或SO 3 H，R 4是氢，氯或溴原子或羧酸或磺酸基团，作为氧化颜色形成反应中的偶联组分。 本发明还提供了一种通过氧化颜色偶联分析测定氧化物质的试剂，其作为偶联组分含有至少一种通式（I）的化合物。

    Use of a bis-maleic anhydride cross-linking agent for fixation of a cell or tissue sample
    9.
    发明授权
    Use of a bis-maleic anhydride cross-linking agent for fixation of a cell or tissue sample 失效
    双马来酸酐交联剂用于固定细胞或组织样品的用途

    公开(公告)号：US08460944B2

    公开(公告)日：2013-06-11

    申请号：US13400862

    申请日：2012-02-21

    Applicant: Hans-Peter Josel ,  Michael Gerg ,  Rupert Herrmann ,  Rosa Isabel Saez Diaz

    Inventor： Hans-Peter Josel ,  Michael Gerg ,  Rupert Herrmann ,  Rosa Isabel Saez Diaz

    IPC: G01N33/557 ,  G01N33/543 ,  G01N33/556 ,  C12Q1/68 ,  C07D407/00 ,  B01L3/00

    CPC classification number: G01N1/30

    Abstract: The present disclosure relates to novel bis-maleic anhydrides and to the surprising discovery that bis-maleic anhydride cross-linking agents can be used for preservation/fixation of a cell or tissue sample. Various bis-maleic anhydride cross-linking agent scan be used in methods requiring fixation of a cell or tissue sample. These reagents and methods are especially useful in procedures that require that the fixation agent be removed in order to facilitate analysis with other reagents. The inventive reagents and methods make it easier to reliably assay for various proteins, a nucleic acid and the like using analytical methods such as like immunohistochemistry, fluorescence in situ hybridization, RT-PCR, and the like.

    Abstract translation: 本公开涉及新颖的双马来酸酐，以及令人惊奇的发现，即双马来酸酐交联剂可用于保存/固定细胞或组织样品。 各种双马来酸酐交联剂扫描用于需要固定细胞或组织样品的方法。 这些试剂和方法在需要除去固定剂以便于与其它试剂分析的方法中特别有用。 本发明的试剂和方法使得可以使用诸如免疫组织化学，荧光原位杂交，RT-PCR等的分析方法更容易地可靠地测定各种蛋白质，核酸等。

    MEASUREMENT OF VITAMIN D
    10.
    发明申请
    MEASUREMENT OF VITAMIN D 有权
    维生素D的测定

    公开(公告)号：US20100285603A1

    公开(公告)日：2010-11-11

    申请号：US12326972

    申请日：2008-12-03

    Applicant: Uwe Kobold ,  Thomas Duelffer ,  Michael Grol ,  Rupert Herrmann ,  Herbert Von der Eltz ,  Leopold Von Proff

    Inventor： Uwe Kobold ,  Thomas Duelffer ,  Michael Grol ,  Rupert Herrmann ,  Herbert Von der Eltz ,  Leopold Von Proff

    IPC: G01N33/00

    CPC classification number: G01N33/82 ,  Y10T436/20 ,  Y10T436/203332

    Abstract: The present invention relates to a method of measuring a vitamin D metabolite in a sample, the method comprising the steps of (a) treating said sample with a vitamin D metabolite releasing reagent under conditions appropriate to release a vitamin D metabolite from vitamin D-binding protein and not to cause protein precipitation, (b) subjecting the treated sample obtained in step (a) to a chromatographic separation, and (c) measuring a vitamin D metabolite during or after said chromatographic separation. The present invention also relates to methods for determining the vitamin D status of a subject, for use in the diagnosis of disease, and to agents and kits for use in performing the methods of the invention.

    Abstract translation: 本发明涉及一种测量样品中维生素D代谢物的方法，所述方法包括以下步骤：（a）在适于从维生素D结合物释放维生素D代谢物的条件下用维生素D代谢物释放试剂处理所述样品 蛋白质，不会引起蛋白质沉淀，（b）使步骤（a）中得到的处理样品进行色谱分离，和（c）在所述色谱分离期间或之后测量维生素D代谢物。 本发明还涉及确定用于疾病诊断的受试者的维生素D状态的方法以及用于实施本发明的方法的试剂和试剂盒。

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