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公开(公告)号:US09315571B2
公开(公告)日:2016-04-19
申请号:US11814668
申请日:2006-01-24
申请人: Ruth Franks , Andrew Grier Buchanan , Albert George Thom , Fraser Ewing Welsh , Philip Antony Bland-Ward , Matthew Alexander Sleeman , Carl Anthony Matthews , Celia Patricia Hart , Jon Eric Hawkinson
发明人: Ruth Franks , Andrew Grier Buchanan , Albert George Thom , Fraser Ewing Welsh , Philip Antony Bland-Ward , Matthew Alexander Sleeman , Carl Anthony Matthews , Celia Patricia Hart , Jon Eric Hawkinson
IPC分类号: C07K16/22 , A61K39/395 , C07K14/48 , A61K39/00
CPC分类号: C07K16/22 , A61K39/3955 , A61K2039/505 , C07K14/48 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralize NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.
摘要翻译: 神经生长因子(NGF)的特异性结合成员,特别是抗NGF抗体分子,特别是人抗体分子,特别是中和NGF活性的那些。 诊断或治疗NGF相关疾病(包括疼痛,哮喘,慢性阻塞性肺病,肺纤维化,其他气道炎症疾病,糖尿病性神经病,心律失常,HIV,关节炎,牛皮癣和癌症)的方法。
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公开(公告)号:US20080107658A1
公开(公告)日:2008-05-08
申请号:US11814668
申请日:2006-01-24
申请人: Ruth Franks , Andrew Buchanan , Albert Thom , Fraser Welsh , Philip Bland-Ward , Matthew Sleeman , Carl Matthews , Celia Hart , Jon Hawkinson
发明人: Ruth Franks , Andrew Buchanan , Albert Thom , Fraser Welsh , Philip Bland-Ward , Matthew Sleeman , Carl Matthews , Celia Hart , Jon Hawkinson
CPC分类号: C07K16/22 , A61K39/3955 , A61K2039/505 , C07K14/48 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralise NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.
摘要翻译: 神经生长因子(NGF)的特异性结合成员,特别是抗NGF抗体分子,特别是人抗体分子,特别是中和NGF活性的那些。 诊断或治疗NGF相关疾病(包括疼痛,哮喘,慢性阻塞性肺病,肺纤维化,其他气道炎症疾病,糖尿病性神经病,心律失常,HIV,关节炎,牛皮癣和癌症)的方法。
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公开(公告)号:US08088736B2
公开(公告)日:2012-01-03
申请号:US12446216
申请日:2007-10-22
申请人: Ruth Franks , Mark Terence Liddament , Lutz Ulrich Jochen Wilhelm Jermutus , Andrew Grier Buchanan
发明人: Ruth Franks , Mark Terence Liddament , Lutz Ulrich Jochen Wilhelm Jermutus , Andrew Grier Buchanan
CPC分类号: C07K14/70521
摘要: Protein variants of CTLA-4, which show increased activity compared to wild-type in a cell assay and which exhibit increased stability. Such variants are useful for treatment of disorders whereby attenuation of the T cell response would be beneficial.
摘要翻译: CTLA-4的蛋白质变体,与细胞测定中的野生型相比显示出增加的活性并且表现出增加的稳定性。 这些变体可用于治疗T细胞应答的衰减将是有益的疾病。
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公开(公告)号:US20100322893A1
公开(公告)日:2010-12-23
申请号:US12446216
申请日:2007-10-22
申请人: Ruth Franks , Mark Terence Liddament , Lutz Ulrich Jochen Wilhelm Jermutus , Andrew Grier Buchanan
发明人: Ruth Franks , Mark Terence Liddament , Lutz Ulrich Jochen Wilhelm Jermutus , Andrew Grier Buchanan
CPC分类号: C07K14/70521
摘要: Protein variants of CTLA-4, which show increased activity compared to wild-type in a cell assay and which exhibit increased stability. Such variants are useful for treatment of disorders whereby attenuation of the T cell response would be beneficial.
摘要翻译: CTLA-4的蛋白质变体,与细胞测定中的野生型相比显示出增加的活性并且表现出增加的稳定性。 这些变体可用于治疗T细胞应答的衰减将是有益的疾病。
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