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公开(公告)号：US20150132354A1
公开(公告)日：2015-05-14
申请号：US14452422
申请日：2014-08-05
CPC分类号： A61L27/54 , A61K38/18 , A61K38/1866 , A61K38/1875 , A61L27/46 , A61L27/56 , A61L2300/414 , A61L2430/02 , C08L89/06
摘要： The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of the bioactive agents over time.
摘要翻译： 本发明提供了一种利用多孔胶原支架的新型复合骨移植系统，其具有浸渍有磷酸钙颗粒和多于一种生物活性剂的基质，其中一种与基质结合。 移植物系统通过提供用于组织附着和繁殖的部位显示出增加的机械强度和成骨性质。 通过不同的机制将生物活性剂递送到支架，以使生物活性剂随时间顺序和持续释放。
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公开(公告)号：US20190083282A1
公开(公告)日：2019-03-21
申请号：US16134453
申请日：2018-09-18
IPC分类号： A61F2/44 , A61L27/56 , B29C67/20 , A61F2/28 , A61L27/54 , A61L27/26 , A61L27/18 , A61L27/12 , C08J9/36 , C08J9/28 , C08J9/00 , A61L27/46 , A61F2/30
摘要： Implantable devices for orthopedic, including spine and other uses are formed of porous reinforced polymer scaffolds. Scaffolds include a thermoplastic polymer forming a porous matrix that has continuously interconnected pores. The porosity and the size of the pores within the scaffold are selectively formed during synthesis of the composite material, and the composite material includes a plurality of reinforcement particles integrally formed within and embedded in the matrix and exposed on the pore surfaces. The reinforcement particles provide one or more of reinforcement, bioactivity, or bioresorption.
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公开(公告)号：US20210000611A9
公开(公告)日：2021-01-07
申请号：US16134453
申请日：2018-09-18
IPC分类号： A61F2/44 , A61L27/56 , B29C67/20 , A61F2/28 , A61L27/54 , A61L27/26 , A61L27/18 , A61L27/12 , C08J9/36 , C08J9/28 , C08J9/00 , A61L27/46 , A61F2/30
摘要： Implantable devices for orthopedic, including spine and other uses are formed of porous reinforced polymer scaffolds. Scaffolds include a thermoplastic polymer forming a porous matrix that has continuously interconnected pores. The porosity and the size of the pores within the scaffold are selectively formed during synthesis of the composite material, and the composite material includes a plurality of reinforcement particles integrally formed within and embedded in the matrix and exposed on the pore surfaces. The reinforcement particles provide one or more of reinforcement, bioactivity, or bioresorption.
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公开(公告)号：US20080206297A1
公开(公告)日：2008-08-28
申请号：US12039666
申请日：2008-02-28
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/30965 , A61F2/4465 , A61F2002/2817 , A61F2002/2835 , A61F2002/30006 , A61F2002/30011 , A61F2002/30034 , A61F2002/30062 , A61F2002/30065 , A61F2002/30225 , A61F2002/30235 , A61F2002/30622 , A61F2002/30904 , A61F2002/3092 , A61F2002/30957 , A61F2210/0004 , A61F2210/0071 , A61F2230/0069 , A61F2250/0015 , A61F2250/0018 , A61F2250/0023 , A61F2250/0031 , A61L27/12 , A61L27/18 , A61L27/26 , A61L27/46 , A61L27/54 , A61L27/56 , B29C67/202 , C08J9/0066 , C08J9/28 , C08J9/36
摘要： Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.
摘要翻译： 本文描述了用作例如整形外科植入物的合成复合材料。 在一个实例中，用作支架的复合材料包括形成具有连续孔隙率和多个孔的多孔基体的热塑性聚合物。 在合成复合材料过程中选择性地形成孔隙率和孔径。 该示例性复合材料还包括一体形成，嵌入或暴露于多孔基质的表面上的多个不等尺寸的磷酸钙颗粒。 磷酸钙颗粒提供一种或多种增强，生物活性或生物再吸收。
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公开(公告)号：US20230127516A1
公开(公告)日：2023-04-27
申请号：US17911354
申请日：2021-02-12
申请人： Lan LI , Ryan K. ROEDER
摘要： A computer-implemented method for revoking access to a first network, wherein the first network comprises a set of bridging nodes and a set of devices controllable by one or more of the set of bridging nodes, wherein each bridging node is also a respective node of a blockchain network, and wherein each bridging node and device is associated with a respective certificate granting access to the first network; the method being performed by a registration authority and comprising: obtaining an alert transaction, the alert transaction being a blockchain transaction and comprising a first output, the first output comprising an alert message identifying one or more bridging nodes and/or one or more devices; and revoking access to the first network by the identified one or more bridging nodes and/or one or more devices by revoking the respective certificate of the identified one or more bridging nodes and/or one or more devices.
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公开(公告)号：US10945854B2
公开(公告)日：2021-03-16
申请号：US14078614
申请日：2013-11-13
IPC分类号： A61F2/44 , A61L27/46 , C08J9/28 , C08J9/36 , A61F2/28 , C08J9/00 , A61L27/56 , A61L27/12 , A61L27/18 , A61L27/26 , A61L27/54 , B29C67/20 , A61F2/30
摘要： Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.
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公开(公告)号：US20210015977A9
公开(公告)日：2021-01-21
申请号：US14078614
申请日：2013-11-13
摘要： Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.
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公开(公告)号：US20140236299A1
公开(公告)日：2014-08-21
申请号：US14078614
申请日：2013-11-13
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/30965 , A61F2/4465 , A61F2002/2817 , A61F2002/2835 , A61F2002/30006 , A61F2002/30011 , A61F2002/30034 , A61F2002/30062 , A61F2002/30065 , A61F2002/30225 , A61F2002/30235 , A61F2002/30622 , A61F2002/30904 , A61F2002/3092 , A61F2002/30957 , A61F2210/0004 , A61F2210/0071 , A61F2230/0069 , A61F2250/0015 , A61F2250/0018 , A61F2250/0023 , A61F2250/0031 , A61L27/12 , A61L27/18 , A61L27/26 , A61L27/46 , A61L27/54 , A61L27/56 , B29C67/202 , C08J9/0066 , C08J9/28 , C08J9/36
摘要： Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.
摘要翻译： 本文描述了用作例如整形外科植入物的合成复合材料。 在一个实例中，用作支架的复合材料包括形成具有连续孔隙率和多个孔的多孔基体的热塑性聚合物。 在合成复合材料过程中选择性地形成孔隙率和孔径。 该示例性复合材料还包括一体形成，嵌入或暴露于多孔基质的表面上的多个不等尺寸的磷酸钙颗粒。 磷酸钙颗粒提供一种或多种增强，生物活性或生物再吸收。
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9.发明授权Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods 有权复合生物材料包括不均匀磷酸钙增强颗粒及相关方法公开(公告)号：US07758882B2
公开(公告)日：2010-07-20
申请号：US10182823
申请日：2001-01-31
申请人： Ryan K. Roeder , Charles H. Turner
发明人： Ryan K. Roeder , Charles H. Turner
IPC分类号： A61F2/28
CPC分类号： A61L24/0084 , A61L27/46
摘要： Composite biomaterials (e.g., for use as orthopedic implants), as well as methods of preparing composite biomaterials, are disclosed. The composite biomaterial includes a matrix (e.g., a continuous phase) comprising a thermoplastic, a calcium phosphate composition that is curable in vivo, or combinations thereof. The composite biomaterial also includes an isometric calcium phosphate reinforcement particles which are dispersed within the matrix.
摘要翻译： 公开了复合生物材料（例如，用作矫形植入物）以及制备复合生物材料的方法。 复合生物材料包括包含热塑性物质，体内可固化的磷酸钙组合物或其组合的基质（例如，连续相）。 复合生物材料还包括分散在基质内的等离子体磷酸钙增强颗粒。
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