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公开(公告)号:US20220089700A1
公开(公告)日:2022-03-24
申请号:US17538731
申请日:2021-11-30
发明人: Stephen F. Anderson , Natalie Anosova , Nicola Beltraminelli , Pierre Garrone , Harold Kleanthous , Majid Mehtali , Jianxin Zhang
摘要: Monoclonal antibodies, or antigen-binding fragments thereof, that bind to Clostridium difficile (C. difficile) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile-associated disease.
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公开(公告)号:US11220537B2
公开(公告)日:2022-01-11
申请号:US16204624
申请日:2018-11-29
发明人: Stephen F. Anderson , Natalie Anosova , Nicola Beltraminelli , Pierre Garrone , Harold Kleanthous , Jianxin Zhang , Majid Mehtali
摘要: Monoclonal antibodies, or antigen-binding fragments thereof, that bind to Clostridium difficile (C. difficile) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile-associated disease.
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公开(公告)号:US20190194626A1
公开(公告)日:2019-06-27
申请号:US16230990
申请日:2018-12-21
发明人: Simon Delagrave , CharChang Lai
IPC分类号: C12N7/00
CPC分类号: C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/16651 , A61K2300/00 , A61K39/12 , A61K39/245 , A61K2039/5254 , A61K35/76 , A61K2039/525 , C12N15/86 , C12N2710/16643 , C12N2710/16034 , C12N2710/16611 , C12N15/869 , C12N2710/16652 , C12N2710/16661 , C07K14/005 , C07K14/035
摘要: Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.
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公开(公告)号:US20180273909A1
公开(公告)日:2018-09-27
申请号:US15761913
申请日:2016-09-19
发明人: Sophia Tara MUNDLE
IPC分类号: C12N7/00 , A61K35/76 , A61K47/26 , B01D63/02 , B01D15/34 , B01D15/38 , B01D61/14 , B01D71/68
CPC分类号: C12N7/00 , A61K35/76 , A61K47/26 , B01D15/34 , B01D15/3847 , B01D61/145 , B01D63/02 , B01D71/68 , C12N2760/00021 , C12N2760/00051 , C12N2760/00064
摘要: Disclosed herein are methods for the purification of Respiratory Syncytial Virus (RSV) particles from a host cell culture comprising treating the host cell culture with an endonuclease, filtering the material to remove cellular debris and/or aggregated material, applying the material to a core bead chromatography resin, and recovering the purified RSV particles. Also disclosed herein are pharmaceutical compositions comprising purified RSV.
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公开(公告)号:US20180000920A1
公开(公告)日:2018-01-04
申请号:US15632480
申请日:2017-06-26
CPC分类号: A61K39/08 , A61K9/0019 , A61K9/19 , A61K39/00 , A61K47/08 , A61K47/12 , A61K47/26 , A61K2039/55505
摘要: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
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公开(公告)号:US20160287689A1
公开(公告)日:2016-10-06
申请号:US14986895
申请日:2016-01-04
CPC分类号: A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
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公开(公告)号:US20160053221A1
公开(公告)日:2016-02-25
申请号:US14833787
申请日:2015-08-24
发明人: Aiqi FANG , Andrew James WHITE , Seshu TUMMALA , Lee WILSON
摘要: The invention provides methods and compositions (such as for example, culture media) for culturing Clostridium difficile and producing the C. difficile Toxins A and B.
摘要翻译: 本发明提供了用于培养艰难梭菌并产生艰难梭菌毒素A和B的方法和组合物(例如培养基)。
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公开(公告)号:US09228203B2
公开(公告)日:2016-01-05
申请号:US13942064
申请日:2013-07-15
发明人: Simon Delagrave , Nathan Brown , Harold Kleanthous , Farshad Guirakhoo , Alexander A. Rumyantsev
IPC分类号: A61K39/12 , A61K39/145 , C12N15/86 , C12N7/00 , A61K39/00
CPC分类号: C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/16134 , C12N2770/24143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
摘要: This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
摘要翻译: 本发明涉及双顺反子黄病毒载体,在预防和治疗疾病中使用这些载体的方法,以及制备此类载体的方法。
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公开(公告)号:US20150024004A1
公开(公告)日:2015-01-22
申请号:US14507319
申请日:2014-10-06
CPC分类号: A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要: The invention provides flavivirus vaccines and methods of making and using these vaccines.
摘要翻译: 本发明提供黄病毒疫苗和制备和使用这些疫苗的方法。
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公开(公告)号:US08852914B2
公开(公告)日:2014-10-07
申请号:US13668819
申请日:2012-11-05
IPC分类号: C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号: A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要: The invention provides flavivirus vaccines and methods of making and using these vaccines.
摘要翻译: 本发明提供黄病毒疫苗和制备和使用这些疫苗的方法。
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