Method for the manufacture of polybranched organic/inorganic hybrid polymers
    2.
    发明授权
    Method for the manufacture of polybranched organic/inorganic hybrid polymers 有权
    制备多支链有机/无机杂化聚合物的方法

    公开(公告)号:US09487632B2

    公开(公告)日:2016-11-08

    申请号:US14330271

    申请日:2014-07-14

    Applicant: SINVENT AS

    CPC classification number: C08G83/005 C07F7/10 C08G77/388 C08G77/54

    Abstract: Polybranched organic/inorganic hybrid polymer and method for its manufacture. The hybrid polymer has the form of an inorganic core carrying organic branches. The core is first prepared by controlled hydrolysis and condensation of a silane with a structure: X—B—Si(—Y)3 in which X═NR1R2, while R1, R2 are chosen among hydrogen, alkyl and aryl, or R1, R2 are chosen among condensation products, addition products of one or more type of chemical substances such as acids, alcohols, phenols, amines, aldehydes or epoxides. B is a linkage group chosen among alkylene and arylene which may include oxygen, nitrogen, sulphur, phosphorous, silicon and boron. Y is chosen among hydrolyzable residues such as alkoxy, carboxyl, and halogen. The organic branches are developed by substituting N—H hydrogen atoms in the X—B group by reactions that are typical for primary and secondary amines, and/or by adding an acid that causes an addition to the N atoms of the X—B group in the core. Specific uses of the hybrid polymers are also indicated.

    Abstract translation: 多分支有机/无机杂化聚合物及其制造方法。 杂化聚合物具有携带有机分支的无机核的形式。 核心首先通过控制水解和缩合具有结构的X-B-Si(-Y)3的硅烷来制备,其中X = NR1R2,而R1,R2选自氢,烷基和芳基,或R1,R2 选自缩合产物,一种或多种类型的化学物质如酸,醇,酚,胺,醛或环氧化物的加成产物。 B是选自亚烷基和亚芳基中的连接基团,其可以包括氧,氮,硫,磷,硅和硼。 Y选自可水解残基如烷氧基,羧基和卤素。 通过用于伯胺和仲胺典型的反应和/或通过加入引入X-B基团的N原子的酸来代替X-B基团中的N-H氢原子而开发有机分支 在核心。 还指出了混合聚合物的具体用途。

    Binding a target substance
    4.
    发明授权

    公开(公告)号:US10816546B2

    公开(公告)日:2020-10-27

    申请号:US14810216

    申请日:2015-07-27

    Applicant: SINVENT AS

    Abstract: Magnetic particles capable of binding a target substance, which comprise a magnetic material and a matrix material, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase.

    Ultrasound contact fluid
    5.
    发明授权

    公开(公告)号:US09770521B2

    公开(公告)日:2017-09-26

    申请号:US14398871

    申请日:2013-05-08

    Applicant: Sinvent AS

    CPC classification number: A61K49/22 A61B8/0808 A61K49/226

    Abstract: An aqueous ultrasound contact fluid includes a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and the use of the ultrasound contact fluid in an intraoperative or interventional ultrasound imaging procedure. A method for intraoperative ultrasound imaging includes filling an aqueous ultrasound contact fluid into a body cavity. The aqueous ultrasound contact fluid is a composition comprising a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and optionally a pharmaceutically acceptable humectant, and the triglyceride content is in the range of 8-240 g/1000 ml composition contact fluid and the amount of emulsifier is 0.4-18 g/1000 ml composition contact fluid, and optionally a humectant in the amount of 1.2-30 g/1000 ml. The method further includes obtaining an ultrasound image of a body region that comprises at least part of the body cavity filled with the aqueous ultrasound contact fluid. The aqueous ultrasound contact fluid reduces image artifacts associated with the body cavity.

    BINDING A TARGET SUBSTANCE
    6.
    发明申请
    BINDING A TARGET SUBSTANCE 审中-公开
    绑定目标物质

    公开(公告)号:US20150329851A1

    公开(公告)日:2015-11-19

    申请号:US14810216

    申请日:2015-07-27

    Applicant: SINVENT AS

    Abstract: Magnetic particles capable of binding a target substance, which comprise a magnetic material and a matrix material, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase.

    Abstract translation: 能够结合包含磁性材料和基体材料的目标物质的磁性颗粒,其中磁性材料在暴露于磁场时是残留的,并且基质材料具有包含在存在下促进颗粒分解的官能团的表面 的液相。

    METHOD FOR SIMULATION OF MULTIPHASE FLUID FLOW IN PIPELINES
    7.
    发明申请
    METHOD FOR SIMULATION OF MULTIPHASE FLUID FLOW IN PIPELINES 审中-公开
    用于模拟管道中多相流体流动的方法

    公开(公告)号:US20150286755A1

    公开(公告)日:2015-10-08

    申请号:US14647068

    申请日:2013-11-21

    CPC classification number: G06F17/5009 G06F17/16 G06F2217/16 G06F2217/34

    Abstract: This invention relates to a method for one dimensional simulation of multiphase fluid flow in pipelines enabling determination of pressure drop, fluid volume fractions, and heat and mass transfer coefficients in multiphase pipeline flows, wherein the method comprises providing real world values of the superficial velocities of each of the continuous fluid phases, the pipe diameter, and the inclination angle of the pipeline relative to the horizontal plane, providing initial values describing the flow geometry of the multiphase flow, where the initial values at least comprises the axial pressure gradient and the positions of the large scale interfaces separating the continuous fluid phases, employing a one-dimensional numerical model based on Eulerian formulated transport equations of the multiphase flow in the pipeline, solving the numerical model with the set of input values from step a) and b) to determine the flow parameters of the multiphase flow, and displaying one or more of the determined flow parameters.

    Abstract translation: 本发明涉及一种用于管道中多相流体流动的一维模拟的方法,其使得能够确定多相管道流中的压降,流体体积分数以及热和质量传递系数,其中该方法包括提供真实世界的表观速度值 每个连续流体相,管道直径和管道相对于水平面的倾斜角,提供描述多相流的流动几何形状的初始值,其中初始值至少包括轴向压力梯度和位置 的分离连续流体相的大规模界面,采用基于欧拉公式的管道中多相流输送方程的一维数值模型,用从步骤a)和b)到b)的输入值集合来求解数值模型 确定多相流的流量参数,并显示一个或多个 确定流量参数。

    NOVEL METHANOL DEHYDROGENASE ENZYMES FROM BACILLUS
    8.
    发明申请
    NOVEL METHANOL DEHYDROGENASE ENZYMES FROM BACILLUS 有权
    来自BACILLUS的新型甲醇脱氢酶

    公开(公告)号:US20150267177A1

    公开(公告)日:2015-09-24

    申请号:US14374878

    申请日:2013-01-25

    CPC classification number: C12N9/0006 C12Y101/01244

    Abstract: The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ ID NOs: 2 (Mdh2-MGA3), 4 (Mdh3-MGA3) or 6 (Mdh2-PB1); and (vi) a nucleotide sequence encoding all or part of a polypeptide which has an amino acid sequence having at least 90% sequence identity, preferably at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4 or 6; or a nucleic acid molecule comprising a nucleotide sequence which is complementary to the nucleotide sequence of any one of (i) to (vi). Also provided are recombinant constructs, vectors and host cells comprising such a nucleic acid molecule and polypeptides encoded thereby. Such molecules may advantageously be used in the genetic modification of host cells, for example to introduce or modify methanol dehydrogenase activity.

    Abstract translation: 本发明涉及编码具有醇脱氢酶活性的多肽,特别是甲醇脱氢酶活性的核酸分子,其包含具有选自以下的核苷酸序列:(i)如以下任一项所述的核苷酸序列: SEQ ID NO:1(mdh2-MGA3),3(mdh3-MGA3)或5(mdh2-PB1); (ii)具有至少90%序列同一性,更特别是至少91,92,93,94,95,96,97,98或99%序列同一性的核苷酸序列,其具有如下任一项所述的核苷酸序列 SEQ ID NO:1,3或5; (iii)与SEQ ID NO:1,3或5的任一核苷酸序列简并的核苷酸序列; (iv)作为SEQ ID NO:1,3或5中任一个核苷酸序列的一部分的核苷酸序列,或与SEQ ID NO:1,3或5的序列退化的核苷酸序列; (v)编码SEQ ID NO:2(Mdh2-MGA3),4(Mdh3-MGA3)或6(Mdh2-PB1)中任一个中氨基酸序列的全部或部分多肽的核苷酸序列; 和(vi)编码全部或部分多肽的核苷酸序列,所述多肽的氨基酸序列具有至少90%的序列同一性,优选至少91,92,93,94,95,96,97,98或99%的序列 同一性,具有SEQ ID NO:2,4或6中任一个所示的氨基酸序列; 或包含与(i)至(vi)中任一个的核苷酸序列互补的核苷酸序列的核酸分子。 还提供了包含这种核酸分子的重组构建体,载体和宿主细胞以及由此编码的多肽。 这样的分子可有利地用于宿主细胞的遗传修饰,例如引入或修饰甲醇脱氢酶活性。

    GAS HYDRATE INHIBITOR, METHOD AND USE OF HYPERBRANCHED POLYESTER POLYOLS AS GAS HYDRATE INHIBITORS
    9.
    发明申请
    GAS HYDRATE INHIBITOR, METHOD AND USE OF HYPERBRANCHED POLYESTER POLYOLS AS GAS HYDRATE INHIBITORS 审中-公开
    气体水合物抑制剂,作为气体水合物抑制剂的高分子聚酯多元醇的方法和用途

    公开(公告)号:US20150252246A1

    公开(公告)日:2015-09-10

    申请号:US14438276

    申请日:2013-10-28

    Applicant: SINVENT AS

    CPC classification number: C09K8/52 C07C69/67 C08G63/91 C09K2208/22 C10L3/107

    Abstract: The present invention relates to a non-toxic and biodegradable low dosage gas hydrate inhibitor comprising hyper-branched polyester polyols having hydroxyl end groups which are chemically modified. Further, the invention relates to a method for controlling gas hydrate formation and plugging of gas hydrate forming fluids and the use of the gas hydrate inhibitors for this purpose.

    Abstract translation: 本发明涉及一种无毒且可生物降解的低剂量气体水合物抑制剂,其包含具有化学修饰的羟基端基的超支化聚酯多元醇。 此外,本发明涉及一种用于控制气体水合物形成流体的气体水合物形成和堵塞以及为此目的使用气体水合物抑制剂的方法。

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