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公开(公告)号：US08273860B2
公开(公告)日：2012-09-25
申请号：US13287494
申请日：2011-11-02
IPC分类号： C07K1/04 , A61K31/496
CPC分类号： C07D401/14 , G01N33/531
摘要： Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.
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公开(公告)号：US08263749B2
公开(公告)日：2012-09-11
申请号：US13287467
申请日：2011-11-02
CPC分类号： C07D401/14 , G01N33/531
摘要： Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.
摘要翻译： 衍生自伊马替尼和由这些免疫原产生的单克隆抗体的新型缀合物和免疫原可用于免疫测定，用于量化和监测生物体液中的伊马替尼或其药理学活性盐。
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公开(公告)号：US20120225443A1
公开(公告)日：2012-09-06
申请号：US13226874
申请日：2011-09-07
IPC分类号： G01N33/566
CPC分类号： G01N33/94 , Y10T436/10 , Y10T436/13
摘要： Use of busulfan amide as stabilized standards in immunoassays for quantifying the amount of busulfan in samples of human biological fluids, methods for carrying out said immunoassay and kits for use in said immunoassay.
摘要翻译： 在免疫测定中使用白消安胺作为稳定的标准物，用于定量人类生物液体样品中的百日咳量，进行所述免疫测定的方法和用于所述免疫测定的试剂盒。
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公开(公告)号：US20110165699A1
公开(公告)日：2011-07-07
申请号：US13039868
申请日：2011-03-03
申请人： Salvatore J. Salamone , Jodi Blake Courtney , Alexander Volkov , Hongxia Zhang , Howard Sard , Vishnumurthy Hegde
发明人： Salvatore J. Salamone , Jodi Blake Courtney , Alexander Volkov , Hongxia Zhang , Howard Sard , Vishnumurthy Hegde
IPC分类号： G01N33/98 , C07K16/44 , C07D491/22 , C07K2/00 , B82Y15/00
CPC分类号： C07D491/22 , C07K16/44 , G01N33/536 , G01N33/577
摘要： Novel conjugates of the pharmaceutically active metabolite of irinotecan and novel immunogens derived from this pharmaceutically active metabolite and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of the pharmaceutically active metabolite of irinotecan in biological fluids.
摘要翻译： 伊立替康的药学活性代谢物和由这些免疫原产生的这种药物活性代谢物和单克隆抗体的新型免疫原的新型缀合物，其可用于定量和监测生物流体中伊立替康的药学活性代谢物的免疫测定。
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公开(公告)号：US20090221786A1
公开(公告)日：2009-09-03
申请号：US12421169
申请日：2009-04-09
申请人： Salvatore J. Salamone , Jodi Blake Courtney , Dennis Stocker , Mahmoud Ahmed ElSohly , Waseem Gul
发明人： Salvatore J. Salamone , Jodi Blake Courtney , Dennis Stocker , Mahmoud Ahmed ElSohly , Waseem Gul
IPC分类号： C07D305/14 , C08G69/00
CPC分类号： G01N33/94 , G01N33/5308 , G01N2407/02 , Y10S436/815
摘要： Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
摘要翻译： 衍生自紫杉醇和由这些紫杉醇相关免疫原产生的单克隆抗体的9和7位的紫杉醇和新型紫杉醇免疫原的新型缀合物可用于免疫测定用于生物流体中紫杉醇的定量和监测。
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公开(公告)号：US20080275221A1
公开(公告)日：2008-11-06
申请号：US12170355
申请日：2008-07-09
IPC分类号： C07K16/44 , C07C307/06 , C07C69/02
CPC分类号： G01N33/5308 , C07C311/06 , C07D207/46 , C07K16/44 , G01N33/94 , Y10S435/81 , Y10S435/961 , Y10S436/815 , Y10S530/807 , Y10T436/13
摘要： Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.
摘要翻译： 来自白消安的α-取代衍生物和由这些白消安结合的免疫原产生的抗体的白消安和新的白消安免疫原的新型缀合物可用于免疫测定用于定量和监测生物流体中的百日咳。
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7.发明授权Site-specific aminoglycoside derivatives for use in immunodiagnostic assays 有权用于免疫诊断测定的位点特异性氨基糖苷衍生物公开(公告)号：US07235370B2
公开(公告)日：2007-06-26
申请号：US10624822
申请日：2003-07-22
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533 , G01N33/534 , C07H5/06
CPC分类号： C07H5/06 , A61K31/7008 , C07H3/06 , C07K16/44 , G01N33/9446 , Y02P20/55 , Y10S435/81 , Y10S435/968 , Y10S436/815 , Y10S530/807 , Y10T436/13
摘要： A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and reagents.
摘要翻译： 制备衍生化的氨基糖苷的方法包括在非质子溶剂中将氨基糖苷与至少2当量的二价金属离子反应以使两个相邻的氨基和羟基对复合; 使非络合氨基与保护试剂反应以提供保护基团; 除去二价金属离子以提供两个未保护的氨基; 使一个未保护的氨基与含有接头，载体或标记的反应性物质反应; 并除去保护基。 该方法可用于生产新型化合物和试剂。
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公开(公告)号：US07175993B2
公开(公告)日：2007-02-13
申请号：US11301101
申请日：2005-12-12
申请人： Salvatore J. Salamone , Jodi Blake Courtney , Dennis Stocker , Mahmoud Ahmed ElSohly , Waseem Gul
发明人： Salvatore J. Salamone , Jodi Blake Courtney , Dennis Stocker , Mahmoud Ahmed ElSohly , Waseem Gul
IPC分类号： G01N33/53 , G01N33/532 , G01N33/551 , C07K16/00 , C07K1/13 , C07K1/04 , C07D305/14
CPC分类号： G01N33/94 , G01N33/5308 , G01N2407/02 , Y10S436/815
摘要： Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
摘要翻译： 衍生自紫杉醇和由这些紫杉醇相关免疫原产生的单克隆抗体的9和7位的紫杉醇和新型紫杉醇免疫原的新型缀合物可用于免疫测定用于生物流体中紫杉醇的定量和监测。
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9.发明授权Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays 有权位点特异性氨基糖苷衍生物及其在免疫诊断测定中的应用公开(公告)号：US06653456B2
公开(公告)日：2003-11-25
申请号：US09920402
申请日：2001-07-31
IPC分类号： C08B3700
CPC分类号： C07H5/06 , A61K31/7008 , C07H3/06 , C07K16/44 , G01N33/9446 , Y02P20/55 , Y10S435/81 , Y10S435/968 , Y10S436/815 , Y10S530/807 , Y10T436/13
摘要： A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and reagents.
摘要翻译： 制备衍生化的氨基糖苷的方法包括在非质子溶剂中将氨基糖苷与至少2当量的二价金属离子反应以使两个相邻的氨基和羟基对复合; 使非络合氨基与保护试剂反应以提供保护基团; 除去二价金属离子以提供两个未保护的氨基; 使一个未保护的氨基与含有接头，载体或标记的反应性物质反应; 并除去保护基。 该方法可用于生产新型化合物和试剂。
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公开(公告)号：US06524808B1
公开(公告)日：2003-02-25
申请号：US09603646
申请日：2000-06-26
申请人： Allan R. Dorn , Salvatore J. Salamone , Mitali Ghoshal , Eva Hoess , Erasmus Huber , Ronald C. Hawley , John W. Patterson
发明人： Allan R. Dorn , Salvatore J. Salamone , Mitali Ghoshal , Eva Hoess , Erasmus Huber , Ronald C. Hawley , John W. Patterson
IPC分类号： C12Q132
CPC分类号： G01N33/5735 , G01N33/78 , G01N2333/904 , Y10S435/975
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
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