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    System and method for prevention of radiocontrast induced nephropathy
    3.
    发明申请
    System and method for prevention of radiocontrast induced nephropathy 审中-公开
    用于预防放射性对照诱导的肾病的系统和方法

    公开(公告)号：US20070213686A1

    公开(公告)日：2007-09-13

    申请号：US11347008

    申请日：2006-02-03

    Applicant: Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

    Inventor： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

    IPC: A61B19/00

    CPC classification number: A61M5/1723 ,  A61B90/00 ,  A61B2017/22082 ,  A61M5/007 ,  A61M25/0068 ,  A61M2005/1403 ,  A61M2025/0037 ,  A61M2025/1045

    Abstract: An apparatus and method particularly useful in treatments and therapies directed at the kidneys such as the prevention of radiocontrast nephropathy (RCN) arising from diagnostic procedures using iodinated contrast materials. A series of treatment schemes are provided based upon local therapeutic agent delivery to the kidneys that can be used as a prophylactic treatment for patients undergoing interventional procedures that have been identified as being at an elevated risk for developing RCN as well as for low risk patients. The methods may include pre-exposure and post contrast exposure treatments alone or in combination with the local delivery of therapeutic agents to the kidneys. Among the agents identified for such treatments are normal saline and the vasodilators papaverine and fenoldopam mesylate and appropriate dosing is provided.

    Abstract translation: 特别适用于针对肾脏的治疗和疗法的装置和方法，例如使用碘化造影剂的诊断程序引起的放射性对比肾病（RCN）的预防。 提供了一系列基于局部治疗剂递送到肾脏的治疗方案，其可用作对已经被鉴定为发展RCN和低风险患者的高风险的介入手术的患者的预防性治疗。 所述方法可以包括单独的暴露前曝光和造影后处理，或与治疗剂局部递送到肾脏的方法。 鉴定用于这种治疗的药剂是生理盐水，并且提供了血管扩张剂罂粟碱和甲磺酸芬诺多胺，并提供适当的给药。

    Rapid-exchange delivery systems for self-expanding stents
    4.
    发明申请
    Rapid-exchange delivery systems for self-expanding stents 有权
    用于自扩张支架的快速交换输送系统

    公开(公告)号：US20050113902A1

    公开(公告)日：2005-05-26

    申请号：US10720032

    申请日：2003-11-20

    Applicant: Timothy Geiser ,  Charles Peterson ,  Andy Denison ,  Stephanie Klocke ,  Samir Patel ,  Joanna Lubas ,  Joanne Lumauig ,  Kathy Lind ,  Keif Fitzgerald

    Inventor： Timothy Geiser ,  Charles Peterson ,  Andy Denison ,  Stephanie Klocke ,  Samir Patel ,  Joanna Lubas ,  Joanne Lumauig ,  Kathy Lind ,  Keif Fitzgerald

    IPC: A61F2/84 ,  A61L29/00 ,  A61M25/00 ,  A61F2/06

    CPC classification number: A61F2/95 ,  A61F2/966 ,  A61M2025/0183

    Abstract: A catheter assembly is provided having an inner member and an outer member extending along a longitudinal axis, the inner member and the outer member having a coaxial configuration and dimensioned for relative axial movement. The outer member may include an anti rotation member adapted to engage with a longitudinal slot formed on the inner member so as to maintain rotational alignment between inner member and outer member. The inner member can be made with a proximal portion made from a tubing such as hypotubing or a coil tubing. The inner member also may be made with a proximal portion made with a support mandrel. A coil tubing can be utilized to form the guide wire receiving member which is attached to the inner member.

    Abstract translation: 提供导管组件，其具有内部构件和沿着纵向轴线延伸的外部构件，内部构件和外部构件具有同轴构造并且被设计成用于相对轴向移动。 外部构件可以包括防旋转构件，其适于与形成在内部构件上的纵向狭槽接合，以便保持内部构件和外部构件之间的旋转对准。 内部构件可以由具有诸如假面或管线管的管子制成的近端部分制成。 内部构件也可以由具有支撑心轴的近端部分制成。 可以使用线圈管来形成附接到内部构件的导丝接收构件。

    SYSTEM AND METHOD FOR PRODUCING T CELLS
    6.
    发明申请
    SYSTEM AND METHOD FOR PRODUCING T CELLS 审中-公开
    用于生产T细胞的系统和方法

    公开(公告)号：US20110236363A1

    公开(公告)日：2011-09-29

    申请号：US13062570

    申请日：2009-09-11

    Applicant: Lung-Ji Chang ,  Ekta Samir Patel

    Inventor： Lung-Ji Chang ,  Ekta Samir Patel

    IPC: A61K35/28 ,  C12N5/0783 ,  C12N5/073 ,  A61P35/00 ,  A61P35/02

    CPC classification number: C12N5/0636 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2502/1394 ,  C12N2502/99

    Abstract: Disclosed herein is a system and method for producing T cells from stem cell populations. Specifically exemplified herein is a culture system and method that produces CD4 cells and/or T cell subtypes from a CD4 lineage using a sample of hematopoietic stem cells. Adult hematopoietic precursor/stem cells (HPC) are progenitors to all lineages of immune cells. There has been limited success in generating functional CD4 T cells with this convenient culture system. Also disclosed herein is a novel stromal cell line expressing DL1, interleukin-7 (IL-7), and FMS-like tyrosine kinase 3 ligand (Flt3-L). This improved culture system can greatly facilitate the study of late T cell development and enables immunotherapeutic applications.

    Abstract translation: 本文公开了一种从干细胞群体产生T细胞的系统和方法。 本文具体示例的是使用造血干细胞样品从CD4谱系产生CD4细胞和/或T细胞亚型的培养系统和方法。 成人造血前体/干细胞（HPC）是免疫细胞所有谱系的祖细胞。 使用这种方便的培养系统产生功能性CD4T细胞的成功有限。 本文还公开了表达DL1，白细胞介素-7（IL-7）和FMS样酪氨酸激酶3配体（Flt3-L）的新型基质细胞系。 这种改进的培养系统可以大大促进晚期T细胞发育的研究，并实现免疫治疗应用。

    Reverse link correlation filter in wireless communication systems
    8.
    发明申请
    Reverse link correlation filter in wireless communication systems 失效
    无线通信系统中的反向链路相关滤波器

    公开(公告)号：US20080075150A1

    公开(公告)日：2008-03-27

    申请号：US11901571

    申请日：2007-09-17

    Applicant: Antoine Rouphael ,  John Hoffmann ,  George Nelson ,  Samir Patel ,  James Proctor ,  Daniel Riley

    Inventor： Antoine Rouphael ,  John Hoffmann ,  George Nelson ,  Samir Patel ,  James Proctor ,  Daniel Riley

    IPC: H04B1/69

    CPC classification number: H04B1/707 ,  H04B1/7105 ,  H04B1/712 ,  H04B2201/70703 ,  H04B2201/70705 ,  H04B2201/7071

    Abstract: A single, common correlation filter (CF) core is provided in a receiver for recovery of data from received code division multiple access (CDMA) signals. Signals are received over CDMA channels with different data rates, where the received signals include user information such as pilot and data symbols that have been spread according to different despreading rates including tier 1, tier 2 and tier 3 rates, where tier 1 is the smallest despreading rate. The received signal is correlated at the smallest despreading rate in the correlation filter (CF) by time multiplexing delayed versions of the pseudorandom noise (PN) code. The correlated information is then demultiplexed and pilot-aided QPSK demodulated. The demodulated information is summed at the proper integer multiple of the tier 1 rate to achieve tier 2 and tier 3 despreading rates. According to an embodiment, the three strongest multipaths components in terms of the received power are selected in a window or time period for optimal information recovery.

    Abstract translation: 在接收机中提供单个公共相关滤波器（CF）核，用于从接收的码分多址（CDMA）信号中恢复数据。 在具有不同数据速率的CDMA信道上接收信号，其中所接收的信号包括诸如导频和数据符号之类的用户信息，所述导频和数据符号根据不同的解扩速率（包括层1，层2和层3速率）进行扩展，其中层1是最小的 解散率。 接收到的信号通过伪随机噪声（PN）码的延迟版本的时间复用以相关滤波器（CF）中的最小解扩频率相关。 然后将相关信息解复用并导频辅助QPSK解调。 解调信息以1级速率的适当整数倍相加，以实现2级和3级解扩速率。 根据实施例，在用于最佳信息恢复的窗口或时间段中选择关于接收功率的三个最强多径分量。

    Systems and methods for bi-lateral guidewire cannulation of branched body lumens
    9.
    发明申请
    Systems and methods for bi-lateral guidewire cannulation of branched body lumens 审中-公开
    分支体腔双向导丝套管的系统和方法

    公开(公告)号：US20060069323A1

    公开(公告)日：2006-03-30

    申请号：US11233562

    申请日：2005-09-22

    Applicant: Jeffrey Elkins ,  Harry Goodson ,  Aurelio Valencia ,  Richard Aboytes ,  Samir Patel

    Inventor： Jeffrey Elkins ,  Harry Goodson ,  Aurelio Valencia ,  Richard Aboytes ,  Samir Patel

    IPC: A61M25/00

    CPC classification number: A61M25/0172 ,  A61M25/01 ,  A61M25/0105 ,  A61M25/0662 ,  A61M25/09

    Abstract: A system and method is provided that is adapted to allow for rapid cannulation of a guidewire into a branch lumen extending from a main lumen in a body of a patient, and in particular into two renal arteries extending from an abdominal aorta wall. A dual lumen catheter shaft delivers first and second pre-shaped guidewires to the location of the renal arteries in the aorta, such that the first and second pre-shaped guidewires self-cannulate within the renal arteries. Additional guidewires and/or interventional devices may be incorporated into the system and method for use with the catheter shaft, or over the two pre-shaped guidewires, to meet a particular need for a particular patient or intended procedure.

    Abstract translation: 提供了一种系统和方法，其适于允许将导丝快速插入到从患者体内的主腔延伸的分支腔中，特别是从腹主动脉壁延伸的两个肾动脉中。 双腔导管轴将第一和第二预形状导丝导管到主动脉中肾动脉的位置，使得第一和第二预成形导丝在肾动脉内自我插管。 额外的导线和/或介入装置可以并入用于导管轴或两个预成形导丝线上的系统和方法，以满足特定患者或预期程序的特定需要。

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